Genotyping for epidemiology studies

流行病学研究的基因分型

• 批准号: 8844942
• 负责人: DAVID HEIMBROOK
• 金额: $ 724.51万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8844942
• 关键词: Affect; Area; Basic Science; Bioinformatics; Cancer Burden; Candidate Disease Gene; Caring; Chronic Lymphocytic Leukemia; Communities; Custom; DNA; Data; Data Analyses; Data Set; Data Storage and Retrieval; Disease; Disease Outcome; Division of Cancer Epidemiology and Genetics; Electronics; Employment; Endometrial Carcinoma; Environmental Risk Factor; Epidemiologic Studies; Epidemiologist; Equipment and supply inventories; Family; Generations; Genes; Genetic; Genetic Markers; Genetic Variation; Genomics; Genotype; Goals; Hand; Hodgkin Disease; Human; Human Genetics; Human Genome; Human Papillomavirus; Individual; Informatics; Information Management; Inherited; Intramural Research Program; Kaposi Sarcoma; Laboratories; Laboratory Research; Link; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of cervix uteri; Malignant neoplasm of esophagus; Malignant neoplasm of larynx; Malignant neoplasm of liver; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Malignant neoplasm of testis; Malignant neoplasm of thyroid; Malignant neoplasm of urinary bladder; Management Information Systems; Molecular Epidemiology; Mosaicism; Multiple Myeloma; Mutation; Non-Hodgkin' s Lymphoma; Outcome; Pancytopenia; Phenotype; Population Group; Predisposition; Preparation; Production; Proteomics; Publications; Quality Control; Rectal Cancer; Renal carcinoma; Research; Research Personnel; Research Project Grants; Resources; Sampling; Science; Scientific Advances and Accomplishments; Scientist; Single Nucleotide Polymorphism; Site; Skin Cancer; Solutions; Staging; Statistical Methods; Surveys; Syndrome; Techniques; Technology; Technology Transfer; Uterine Cancer; Variant; Work; cancer genomics; case control; cost; cost effective; database of Genotypes and Phenotypes; design; epidemiology study; exome; exome sequencing; follow-up; genetic epidemiology; genetic variant; genome sequencing; genome wide association study; high throughput screening; improved; leukemia; malignant breast neoplasm; malignant stomach neoplasm; melanoma; new product development; next generation sequencing; novel; osteosarcoma; quality assurance; research and development; tool; working group

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians and basic research scientists in the intramural research program, CGR developed the capacity to conduct genome-wide association studies (GWAS), candidate gene approaches, and next-generation sequencing applications to identify the heritable determinants of various forms of cancer. In addition to offering the latest in genomics technology, the CGR is a fully integrated and highly automated laboratory supporting several functional areas: DNA Extraction and Staging Laboratory (DESL) for preparation of samples; Laboratory Information Management System (LIMS) for advanced sample, project, and inventory tracking; comprehensive project management; production laboratory for high-throughput assays; quality assurance and control; research and development for focused research projects and new product development; and bioinformatics and scientific analysis capabilities, making it a unique collaborative center for NCI-driven scientific endeavors.

癌症基因组学研究（CGR）实验室的建立是为了研究遗传变异对癌症易感性和结果的贡献。与流行病学家，生物统计学家和基础研究科学家在校内研究计划合作，CGR开发了进行全基因组关联研究（GWAS），候选基因方法和下一代测序应用的能力，以确定各种形式癌症的遗传决定因素。除了提供最新的基因组学技术，CGR是一个完全集成和高度自动化的实验室，支持几个功能领域：DNA提取和样品制备实验室（DESL）;实验室信息管理系统（LIMS），用于先进的样品，项目和库存跟踪;全面的项目管理;高通量分析的生产实验室;质量保证和控制;重点研究项目和新产品开发的研究和开发;生物信息学和科学分析能力，使其成为一个独特的合作中心，为国家癌症研究所驱动的科学努力。