Genotyping for epidemiology studies

癌症基因组研究实验室(CGR)的成立是为了研究基因变异对癌症易感性和结果的贡献。CGR与流行病学家、生物统计学家和基础研究科学家在内部研究计划中合作，开发了进行全基因组关联研究(Gwas)、候选基因方法和下一代测序应用程序的能力，以确定各种形式癌症的可遗传决定因素。除了提供最新的基因组学技术，CGR还是一个完全集成的高度自动化的实验室，支持几个功能领域：用于样本准备的DNA提取和分级实验室(DESL)；用于高级样本、项目和库存跟踪的实验室信息管理系统(LIMS)；全面的项目管理；用于高通量分析的生产实验室；质量保证和控制；重点研究项目和新产品开发的研发；以及生物信息学和科学分析能力，使其成为NCI驱动的科学努力的独特协作中心。

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians and basic research scientists in the intramural research program, CGR developed the capacity to conduct genome-wide association studies (GWAS), candidate gene approaches, and next-generation sequencing applications to identify the heritable determinants of various forms of cancer. In addition to offering the latest in genomics technology, the CGR is a fully integrated and highly automated laboratory supporting several functional areas: DNA Extraction and Staging Laboratory (DESL) for preparation of samples; Laboratory Information Management System (LIMS) for advanced sample, project, and inventory tracking; comprehensive project management; production laboratory for high-throughput assays; quality assurance and control; research and development for focused research projects and new product development; and bioinformatics and scientific analysis capabilities, making it a unique collaborative center for NCI-driven scientific endeavors.