Core A Admin

行政核心--核心A：项目摘要/摘要 BIOCARD研究是一项纵向的观察性研究，对349名认知正常和 注册时主要为中年(平均年龄为57.1岁)。这些受试者现在已经被跟踪了长达27年。 该项目的总体目标是进一步推进临床前阿尔茨海默病的研究 通过：(1)澄清AD生物标志物(包括基于脑脊液、血液、MRI、 和PET成像)和认知；待研究的生物标记物包括几个有前途的新生物标记物 从血液、脑脊液和脑成像中提取。(2)通过与多家公司协作，最大限度地利用我们的数据 拥有可比较数据的研究小组，以及(3)提供公开可访问的数据、脑扫描和 生物标本，供该领域的研究人员使用。为了实现这些目标，我们建立了7个核心， 本申请，还包括2个项目。管理核心(核心A)负责 项目的整体运作和协调。具体目标包括：(1)监督和整合 在核心和项目方面，(2)协助保留科目和监督征聘工作 更多参与者，(3)与约翰·霍普金斯大学以外的调查人员合作，(4)保证 健全的财政管理，(5)保证项目的所有方面都符合地方和联邦的要求 条例，(6)通过科学咨询委员会的会议协调项目的外部审查 和资源分配委员会，以及(7)与国家老龄研究所的工作人员沟通 关于这项研究的进展。

ADMINISTRATIVE CORE – CORE A: PROJECT SUMMARY/ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. The subjects have now been followed for up to 27 years. The overall objectives of the project are to further advance the study of preclinical Alzheimer’s disease by: (1) clarifying the pattern and rate of change in AD biomarkers (including those based on CSF, blood, MRI, and PET imaging) and cognition; the biomarkers to be studied include several promising novel biomarkers derived from blood, CSF and brain imaging. (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible data, brain scans, and biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores and, with this application, are also including 2 projects. The Administrative Core (Core A) is responsible for the overall functioning and coordination of the project. The specific aims include: (1) oversight and integration of the Cores and the Projects, (2) assistance with subject retention and oversight of the recruitment of additional participants, (3) collaboration with investigators outside of Johns Hopkins University, (4) assurance of sound fiscal management, (5) assurance that all aspects of the project comply with local and federal regulations, (6) coordinating external review of the project through meetings of the Scientific Advisory Board and the Resource Allocation Committee, and (7) communicating with the staff of the National Institute on Aging about the progress of the study.