Regulatory Factors in the GI Tract

概述（由申请人提供）：华盛顿大学消化疾病研究核心中心（WU-DDRCC）的总体目标是协助研究人员探索消化疾病病理生理学中宿主-环境相互作用的基础。WU-DDRCC旨在通过支持使能技术和促进其49个正式成员+ 11个准成员的基础和转化研究兴趣来促进消化系统疾病患者的健康，DDRCC在一个全面的项目中促进研究基地的专业知识和兴趣，该项目与人类遗传学和微生物组的独特机构优势在战略上保持一致。该中心根据其成员的需求进行了调整，并通过提供培训、技术支持和独特的集中资源来组织临床元数据和生物标本的核心实验室，提供核心支持和使能技术，以扩大成员的研究能力。此外，该中心还提供了一个试点/可行性计划，为希望从事消化疾病研究的初级研究人员提供启动和支持。最后，中心有一个科学充实计划，支持访问科学家的讲座和研讨会，促进成员之间的互动和合作。wddrcc包括49个正式成员，总tdc为2380万美元。研究基地包括研究人员，他们的兴趣跨越三个主要领域，具体来说：(1)宿主-微生物相互作用/炎症/粘膜免疫；(2)干细胞生物学/发育/上皮更新/癌症生物学；(3)营养转运/代谢/信号传导。正式成员/研究基地的研究兴趣在这三大类中大致相同，同时保持对消化疾病的宿主环境因素的强烈关注。WU-DDRCC包括四个核心，包括一个管理和资源访问核心（ARAC），一个生物库核心，一个小鼠模型核心和一个高级成像和组织分析核心。此外，WU-DDRCC有一个积极的浓缩计划和一个试点/可行性计划，支持和培养新的研究人员向科学独立过渡。

DESCRIPTION, OVERALL (provided by applicant): The overarching goal of the Washington University Digestive Disease Research Core Center, (WU-DDRCC) is to assist investigators exploring the foundations of host-environment interactions in the pathophysiology of digestive diseases. The WU-DDRCC seeks to advance the health of patients with digestive diseases by supporting enabling technology and promoting the basic and translational research interests of its 49 Full + 11 Associate members, he DDRCC promotes the expertise and interests of the Research Base in a comprehensive program that is strategically aligned with the distinguishing institutional strengths in human genetics and the microbiome. The Center is justified by the needs of its members and has adapted to provide core support and enabling technology that expands members' research capacity through core laboratories that provide training, technical support and a unique centralized resource for organization of clinical metadata and biospecimens. In addition, the Center provides a Pilot/Feasibility Program that offers start up and support to junior investigators wishing to pursue digestive disease research. Finally, the Center has a scientific Enrichment Program that supports lectures and workshops by visiting scientists and promotes interactions and collaborations among the members. The WU-DDRCC includes 49 Full members with overall TDCs of $23.8M. The Research Base includes investigators whose interests span three major areas, specifically (1) Host-microbial interactions/inflammations/mucosal immunity; (2) Stem cell biology/development/epithelial renewal/cancer biology; (3) Nutrient transport/metabolism/ signaling. The research interests of the Full members/Research Base are approximately equally represented among these three broad categories while simultaneously maintaining a strong focus on host-environmental factors in digestive disease. The WU-DDRCC includes four Cores, including an Administrative and Resource Access Core (ARAC), a Biobank Core, a Murine Models Core and an Advanced Imaging and Tissue Analysis Core. In addition, the WU-DDRCC has an active Enrichment Program and a Pilot/Feasibility Program that has supported and nurtured new investigators as they transition to scientific independence.