Regulatory Factors in the GI Tract

胃肠道的调节因素

• 批准号: 8029493
• 负责人: Nicholas O. Davidson
• 金额: $ 112.15万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8029493
• 关键词: Regulatory; Factors; GI; Tract

DESCRIPTION, OVERALL (provided by applicant): This application is for continued support of the Digestive Diseases Research Core Center (DDRCC) at Washington University St. Louis, which is the central institutional resource for investigators interested in the regulatory mechanisms and pathophysiology of the gastrointestinal tract and liver. The central focus of investigation is on inflammatory bowel diseases and its complications. However, we take a broad view of relevant research and will continue to support research on basic biological processes relevant to inflammatory bowel diseases, even if the systems being studied are not immediately applicable to inflammatory bowel diseases. The DDRCC supports an outstanding Research Base consisting of 62 Investigators in 10 departments with research grants totaling $17.5 million dollars (47% NIDDK funding). The DDRCC sustains its strong Research Base by actively supporting career development of new investigators through its Pilot/Feasibility Program. Nine former and four current Pilot/Feasibility awardees currently contribute to the Research Base. Four research core facilities (Murine Models/Gnotobiotic Core, Morphology Core, Functional Genomics Core and Proteomics Core) play a central role in promoting collaboration and synergy between individuals. They pool resources to provide services and expertise that would be cost and time- prohibitive to develop de novo, and maintain. To facilitate the conduct of clinical and translational research in inflammatory bowel diseases, the Clinical Component of the DDRCC consists of a Tissue Procurement Facility archives clinical samples linked to longitudinal clinical information ( >1,100 patients with inflammatory bowel diseases recruited in three years) and promotes new collaborative and synergistic interactions between basic researchers and clinicians. The DDRCC Clinical Component and Research Core facilities are integrated within the framework of the Clinical Translational Science Award - sponsored biomedical informatics infrastructure. By collecting clinical samples and linking them to integrated clinical information collected in focused longitudinal studies and research data generated from these samples by the DDRCC Research Core Facilities, the DDRCC is building a comprehensive multidimensional discovery platform from which investigators can launch further hypothesis-driven studies on inflammatory bowel disease pathogenesis.

总体描述（由申请人提供）： 本申请旨在继续支持圣路易斯华盛顿大学消化疾病研究核心中心（DDRCC），该中心是对胃肠道和肝脏的调节机制和病理生理学感兴趣的研究人员的中心机构资源。调查的中心焦点是炎症性肠病及其并发症。然而，我们对相关研究持广泛的观点，并将继续支持与炎症性肠病相关的基本生物学过程的研究，即使正在研究的系统不能立即适用于炎症性肠病。DDRCC支持一个杰出的研究基地，由10个部门的62名研究人员组成，研究赠款总额为1750万美元（NIDDK资金的47%）。DDRCC通过其试点/可行性计划积极支持新研究人员的职业发展，以维持其强大的研究基础。九名前和四名现任试点/可行性获奖者目前为研究基地做出了贡献。四个研究核心设施（小鼠模型/Gnotobiotic核心，形态学核心，功能基因组学核心和蛋白质组学核心）在促进个人之间的合作和协同作用中发挥着核心作用。他们集中资源提供服务和专业知识，重新开发和维护成本和时间都很高。为了促进炎症性肠病的临床和转化研究，DDRCC的临床组成部分包括组织采购设施，将临床样本与纵向临床信息（三年内招募了超过1，100名炎症性肠病患者）联系起来，并促进基础研究人员和临床医生之间新的合作和协同互动。DDRCC临床部分和研究核心设施被整合在临床转化科学奖赞助的生物医学信息学基础设施的框架内。通过收集临床样本并将其与DDRCC研究核心设施从这些样本中产生的集中纵向研究和研究数据中收集的综合临床信息联系起来，DDRCC正在建立一个全面的多维发现平台，研究人员可以从该平台启动进一步的假设驱动研究炎症性肠病发病机制。