Regulatory Factors in the GI Tract

总体描述(由申请人提供)： 这项申请是为了继续支持位于华盛顿大学圣路易斯分校的消化疾病研究核心中心(DDRCC)，该中心是对胃肠道和肝脏的调节机制和病理生理学感兴趣的研究人员的核心机构资源。调查的中心焦点是炎症性肠病及其并发症。然而，我们从广泛的角度看待相关研究，并将继续支持与炎症性肠病相关的基本生物学过程的研究，即使正在研究的系统不立即适用于炎症性肠病。DDRCC支持一个杰出的研究基地，该基地由10个部门的62名研究人员组成，研究拨款总额为1750万美元(NIDDK资助47%)。发改委通过其试点/可行性方案积极支持新调查人员的职业发展，从而维持其强大的研究基础。9名前飞行员/可行性奖获得者和4名现任飞行员/可行性奖获得者目前为研究基地作出了贡献。四个研究核心设施(小鼠模型/GnotoBiotic核心、形态核心、功能基因组核心和蛋白质组核心)在促进个体之间的协作和协同方面发挥着核心作用。他们集中资源提供服务和专业知识，而这些服务和专业知识的开发和维护将是成本和时间上的障碍。为了促进炎症性肠病的临床和转化性研究的开展，DDRCC的临床部分由一个组织采购设施组成，它将临床样本与纵向临床信息联系起来(&gt；在三年内招募了1100名炎症性肠病患者)，促进基础研究人员和临床医生之间新的协作和协同互动。DDRCC临床组件和研究核心设施被整合在由临床翻译科学奖赞助的生物医学信息学基础设施的框架内。通过收集临床样本，并将它们与在重点纵向研究中收集的综合临床信息和DDRCC研究核心设施根据这些样本产生的研究数据相联系，DDRCC正在建立一个全面的多维发现平台，研究人员可以在这个平台上启动对炎症性肠病发病机制的进一步假设驱动的研究。

DESCRIPTION, OVERALL (provided by applicant): This application is for continued support of the Digestive Diseases Research Core Center (DDRCC) at Washington University St. Louis, which is the central institutional resource for investigators interested in the regulatory mechanisms and pathophysiology of the gastrointestinal tract and liver. The central focus of investigation is on inflammatory bowel diseases and its complications. However, we take a broad view of relevant research and will continue to support research on basic biological processes relevant to inflammatory bowel diseases, even if the systems being studied are not immediately applicable to inflammatory bowel diseases. The DDRCC supports an outstanding Research Base consisting of 62 Investigators in 10 departments with research grants totaling $17.5 million dollars (47% NIDDK funding). The DDRCC sustains its strong Research Base by actively supporting career development of new investigators through its Pilot/Feasibility Program. Nine former and four current Pilot/Feasibility awardees currently contribute to the Research Base. Four research core facilities (Murine Models/Gnotobiotic Core, Morphology Core, Functional Genomics Core and Proteomics Core) play a central role in promoting collaboration and synergy between individuals. They pool resources to provide services and expertise that would be cost and time- prohibitive to develop de novo, and maintain. To facilitate the conduct of clinical and translational research in inflammatory bowel diseases, the Clinical Component of the DDRCC consists of a Tissue Procurement Facility archives clinical samples linked to longitudinal clinical information ( >1,100 patients with inflammatory bowel diseases recruited in three years) and promotes new collaborative and synergistic interactions between basic researchers and clinicians. The DDRCC Clinical Component and Research Core facilities are integrated within the framework of the Clinical Translational Science Award - sponsored biomedical informatics infrastructure. By collecting clinical samples and linking them to integrated clinical information collected in focused longitudinal studies and research data generated from these samples by the DDRCC Research Core Facilities, the DDRCC is building a comprehensive multidimensional discovery platform from which investigators can launch further hypothesis-driven studies on inflammatory bowel disease pathogenesis.