REGULATORY FACTORS IN THE GI TRACT

描述(由申请人提供)： 这项申请是为了继续支持位于华盛顿大学圣路易斯分校的消化疾病研究核心中心(DDRCC)，专注于胃肠道的调节因素。我们相信，通过对胃肠道过程调控的基本了解，我们将能够更合理地预防和治疗胃肠道疾病，包括消化性溃疡、炎症性肠病和急慢性肝病。我们的理念是，在消化疾病相关研究中开发新机会的最有效方式是投资于有动力的个人，特别是在他们职业生涯的早期阶段。因此，华盛顿大学DDRCC的重点是指导和培训学生、住院医生、研究员和初级教员，目的是在与消化疾病相关的研究中培养新的独立调查人员。该中心通过我们的试点/可行性计划，在培养年轻的独立研究人员方面表现出色。我们的成功还可以通过以下事实来衡量：自2000年该中心成立以来，与NIDDK消化系统疾病相关的研究基地总数和NIDDK相关研究基础都增加了一倍多。消化疾病研究核心中心的方案主题反映了其突出的研究基础，包括：1.宿主-微生物相互作用、炎症和粘膜免疫；肠道发育、分化和上皮更新；营养物质的运输、代谢和信号传递；肝胆代谢，损伤修复。华盛顿大学DDRCC调查人员在这些方案主题中的每一个都走在了前列。初级DDRCC研究人员和临床胃肠病专家之间的合作伙伴关系导致了治疗炎症性肠病的新范式。DDRCC调查人员率先使用实验室和临床人体样本的DNA微阵列分析，在四个方案主题中的每一个中确定新的生物标记物和介体。这些成功反过来又促使我们提议扩大研究核心服务，包括诺生元、激光捕获显微切割、DNA微阵列、蛋白质组学和生物信息学。DDRCC的目标是通过其四个研究核心设施(小鼠模型、形态学、功能基因组学和蛋白质组学)继续促进和加强跨学科的消化系统疾病研究。

DESCRIPTION (provided by applicant): This application is for continued support of the Digestive Diseases Research Core Center (DDRCC) at Washington University St. Louis, focusing on regulatory factors in the GI tract. We believe that by gaining a fundamental understanding of the regulation of GI-processes, we will be able to more rationally prevent and treat GI diseases, including peptic ulcer, inflammatory bowel disease and acute and chronic liver diseases. Our philosophy is that the most effective way to develop new opportunities in digestive diseases related research is to invest in motivated individuals, especially at early stages of their careers. Consequently, the Washington University DDRCC focuses on mentoring and training students, residents, fellows and junior faculty with the goal of fostering new independent investigators in digestive diseases-related research. This center has excelled in developing young independent researchers though our Pilot/Feasibility Program. Our success can also be measured by the fact that both total extramural and NIDDK digestive diseases-related research base has more than doubled since the center's inception in 2000. The programmatic themes of the Digestive Diseases Research Core Center reflect its outstanding research base and are: 1.) Host-microbial interactions, inflammation and mucosal immunity; 2.) Gut development, differentiation and epithelial renewal; 3.) Nutrient transport, metabolism and signaling; 4.) Hepatobiliary metabolism, injury-repair. Washington University DDRCC investigators have been at the forefront in each of these programmatic themes. Partnership between a junior DDRCC investigator and clinical gastroenterologist has led to a novel paradigm in the treatment of inflammatory bowel disease. DDRCC investigators have pioneered the use of DNA microarray analyses of laboratory and clinical human samples to identify novel biomarkers and mediators in each of the four programmatic themes. These successes have in turn prompted us to propose to expand the Research Core services, including gnotobiotics, laser capture microdissection, DNA microarray, proteomics and bioinformatics. The goals of this DDRCC are to continue to promote and enhance interdisciplinary digestive disease research through its four research core facilities (Murine Models, Morphology, Functional Genomics and Proteomics).