Rheumatic Diseases Research Training Grant

描述（由申请人提供）：该计划旨在培养博士后研究人员，在MD，MD/PhD和博士科学家的水平，对风湿性疾病领域的生物医学研究感兴趣。该培训计划将包括12 - 36个月的实验室实验室实验经验，在导师的密切监督下，致力于与类风湿性疾病相关的免疫学，分子生物学或生物化学问题，重点是产生新的基于研究的转化方法风湿性疾病，并最终潜在的新的靶向治疗干预措施。共同指导和团队指导是该计划的特点，以适合学员和研究项目的个性化方式，融合多个导师的互补技能和资源。所有受训人员都将学习科学道德和科学方法。其他正式的学术课程工作是为那些感兴趣的，在学员和导师的自由裁量权。培训将是医生和MD/PhD，他们已经完成了一年的实习和两年或两年以上的内部员工培训，通常是普通内科，或博士科学家，他们有兴趣致力于风湿性疾病相关主题的研究工作。学员将根据他们以前的学术表现，研究经验，出版物，面试和主管的建议进行选择。优先考虑那些在风湿病和免疫疾病方面具有公认的研究兴趣，并证明有研究能力的人。四名博士后研究员将被选中参加为期三年的奖学金。在完成培训后，他们将准备成功地竞争医学院或研究机构的全职学术职位。我们预计，大多数医生和医学博士/博士将在医学系内担任风湿病学家，或在学术中心或工业界担任研究科学家。主要培训单位将是加州大学圣地亚哥分校医学系的流变学、过敏和免疫学分部。在UCSD，培训可以在位于拉霍亚的生物医学科学，Leichtag和临床科学大楼的研究实验室获得，或者圣地亚哥退伍军人管理局医疗中心也位于拉霍亚的UCSD校园附近。额外的培训可在加州大学圣地亚哥分校儿科，生物工程和药理学，遗传学部门，并在附近的研究机构在拉霍亚研究中心（即，斯克里普斯研究所、拉霍亚过敏和免疫学研究所和桑福德-伯纳姆研究所）。丰富的患者样本资源和临床研究咨询资源也可通过UCSD临床和转化研究所，UCSD创新治疗临床研究中心，以及UCSD医疗中心和VA医疗中心的临床设施获得。

DESCRIPTION (provided by applicant): The proposed program is designed to train postdoctoral researchers, at the level of MDs, MD/PhDs, and PhD scientists, interested in biomedical research in the area of rheumatic diseases. The training program will consist of a bench research laboratory experience of 12-36 months, under the close supervision of a mentor working on immunologic, molecular biologic, or biochemical problems relevant to the rheumatoid diseases, with an emphasis on generating novel research-based translational approaches to rheumatic diseases and ultimately, potential new targeted therapeutic interventions. Co-mentoring and team mentoring are features of the program, to mesh complementary skills and resources of more than one preceptor, in an individualized manner appropriate to the trainee and research project. All trainees will take courses in scientific ethic and scientific methodology. Other formal academic course work is available for those interested, at the discretion of the trainee and mentor. Training will be physicians, and MD/PhDs, who have completed one year of internship and two or more years of house staff training, usually in general internal medicine, or PhD scientists with an interest in devoting research efforts to subjects relevant to rheumatic diseases. Trainees will be chosen on the basis of their prior academic performance, research experience, publications, interviews, and recommendations from supervisors. Preference will be given to those with acknowledged research interests in rheumatologic and immunologic diseases, and demonstrated capacities in research. Four postdoctoral fellows will be selected to participate in the three-year fellowship. At the completio of the training, they will be prepared to compete successfully for full-time academic positions in medical schools or research institutes. We anticipate that the majority of the physicians and MD/PhDs will operate as rheumatologists within Departments of Medicine or as research scientists in academic centers or industry. The primary training unit will be the Rheumatology, Allergy and Immunology Division, in the Department of Medicine, University of California, San Diego, School of Medicine. At UCSD, training can be obtained in research laboratories located at the Biomedical Science, Leichtag, and Clinical Sciences Building located in La Jolla, or the San Diego Veterans Administration Medical Center also located adjoining the UCSD campus in La Jolla. Additional training is available in the UCSD Departments of Pediatrics, Bioengineering and Pharmacology, Genetics, and at nearby research institutions in the La Jolla research hub (i.e., the Scripps Research Institute, the La Jolla Institute of Allergy and Immunology, and the Sanford-Burnham Institute). Abundant patient sample resources and clinical research consultative resources are also available through the UCSD Clinical and Translational Research Institute, the UCSD Center for Innovative Therapy clinical research unit, and clinical facilities a UCSD Medical Center and the VA Medical Center.