Rheumatic Diseases Research Training Grant

描述(由申请人提供)：该计划旨在培养对风湿病领域的生物医学研究感兴趣的医学博士、医学博士和博士等博士后研究人员。培训计划将包括12-36个月的实验室经验，在导师的密切监督下，从事与类风湿性疾病相关的免疫学、分子生物学或生化问题，重点是产生针对风湿性疾病的新的基于研究的翻译方法，并最终产生潜在的新的靶向治疗干预措施。共同指导和团队指导是该计划的特点，以适合受训者和研究项目的个性化方式，将多名导师的互补技能和资源结合在一起。所有受训人员都将参加科学伦理和科学方法论课程。其他正式的学术课程可供感兴趣的人使用，由学员和导师自行决定。培训对象为医生和医学博士，他们已完成一年的实习和两年或两年以上的内部工作人员培训，通常是普通内科，或者博士科学家，他们有兴趣致力于与风湿病相关的课题的研究。受训者将根据他们以前的学术表现、研究经验、出版物、面试和主管的推荐来选择。将优先考虑那些在风湿学和免疫学疾病方面有公认的研究兴趣，并表现出研究能力的人。将选出四名博士后研究员参加为期三年的奖学金。在完成培训后，他们将准备成功竞争医学院或研究机构的全职学术职位。我们预计，大多数内科医生和医学博士将在医学系担任风湿病专家，或在学术中心或行业担任研究科学家。主要培训单位将是加州大学圣地亚哥分校医学院医学系的风湿病、过敏和免疫科。在加州大学圣迭戈分校，可以在位于拉霍亚的莱希塔格生物医学和临床科学大楼或圣地亚哥退伍军人管理局医疗中心的研究实验室获得培训，圣地亚哥退伍军人管理局医疗中心也位于拉霍亚的加州大学圣迭戈分校。在加州大学圣迭戈分校的儿科、生物工程和药理学、遗传学系以及附近拉霍亚研究中心的研究机构(即斯克里普斯研究所、拉霍亚过敏和免疫学研究所和桑福德-伯纳姆研究所)都提供了额外的培训。丰富的患者样本资源和临床研究咨询资源还可以通过加州大学伯克利分校的临床和转化研究所、加州大学伯克利分校的创新治疗中心临床研究单位以及加州大学伯克利分校医学中心和退伍军人医学中心的临床设施获得。

DESCRIPTION (provided by applicant): The proposed program is designed to train postdoctoral researchers, at the level of MDs, MD/PhDs, and PhD scientists, interested in biomedical research in the area of rheumatic diseases. The training program will consist of a bench research laboratory experience of 12-36 months, under the close supervision of a mentor working on immunologic, molecular biologic, or biochemical problems relevant to the rheumatoid diseases, with an emphasis on generating novel research-based translational approaches to rheumatic diseases and ultimately, potential new targeted therapeutic interventions. Co-mentoring and team mentoring are features of the program, to mesh complementary skills and resources of more than one preceptor, in an individualized manner appropriate to the trainee and research project. All trainees will take courses in scientific ethic and scientific methodology. Other formal academic course work is available for those interested, at the discretion of the trainee and mentor. Training will be physicians, and MD/PhDs, who have completed one year of internship and two or more years of house staff training, usually in general internal medicine, or PhD scientists with an interest in devoting research efforts to subjects relevant to rheumatic diseases. Trainees will be chosen on the basis of their prior academic performance, research experience, publications, interviews, and recommendations from supervisors. Preference will be given to those with acknowledged research interests in rheumatologic and immunologic diseases, and demonstrated capacities in research. Four postdoctoral fellows will be selected to participate in the three-year fellowship. At the completio of the training, they will be prepared to compete successfully for full-time academic positions in medical schools or research institutes. We anticipate that the majority of the physicians and MD/PhDs will operate as rheumatologists within Departments of Medicine or as research scientists in academic centers or industry. The primary training unit will be the Rheumatology, Allergy and Immunology Division, in the Department of Medicine, University of California, San Diego, School of Medicine. At UCSD, training can be obtained in research laboratories located at the Biomedical Science, Leichtag, and Clinical Sciences Building located in La Jolla, or the San Diego Veterans Administration Medical Center also located adjoining the UCSD campus in La Jolla. Additional training is available in the UCSD Departments of Pediatrics, Bioengineering and Pharmacology, Genetics, and at nearby research institutions in the La Jolla research hub (i.e., the Scripps Research Institute, the La Jolla Institute of Allergy and Immunology, and the Sanford-Burnham Institute). Abundant patient sample resources and clinical research consultative resources are also available through the UCSD Clinical and Translational Research Institute, the UCSD Center for Innovative Therapy clinical research unit, and clinical facilities a UCSD Medical Center and the VA Medical Center.