Rheumatic Diseases Research Training Grant

描述（由申请人提供）：拟建项目旨在培养对风湿病领域生物医学研究感兴趣的博士后、医学博士、医学博士/博士和博士科学家。培训计划将包括12-36个月的实验室研究经验，在与类风湿疾病相关的免疫学、分子生物学或生化问题的导师的密切监督下，重点是为类风湿疾病产生新的基于研究的转化方法，并最终产生潜在的新的靶向治疗干预措施。联合指导和团队指导是该计划的特点，以适合学员和研究项目的个性化方式，将多个导师的互补技能和资源结合起来。所有学员将学习科学伦理和科学方法论课程。其他正式的学术课程工作可供感兴趣的人，由学员和导师自行决定。培训对象将是完成了一年实习和两年或两年以上医院员工培训（通常是普通内科）的医生和医学博士/博士，或者是对风湿病相关课题的研究感兴趣的博士科学家。受训者将根据他们之前的学术表现、研究经验、出版物、采访和导师的推荐来选择。在风湿病和免疫疾病方面有公认的研究兴趣，并有研究能力者优先考虑。将选出4名博士后参加为期三年的奖学金。在培训结束后，他们将为成功竞争医学院或研究机构的全职学术职位做好准备。我们预计，大多数内科医生和医学博士/博士将在医学系担任风湿病学家，或在学术中心或行业担任研究科学家。主要培训单位将是加州大学圣地亚哥分校医学院医学系的风湿病学、过敏和免疫学部门。在加州大学圣地亚哥分校，可以在位于拉霍亚的生物医学科学、莱希塔格和临床科学大楼的研究实验室进行培训，或者在圣地亚哥退伍军人管理医疗中心进行培训，该中心也位于加州大学圣地亚哥分校拉霍亚校区附近。在加州大学圣地亚哥分校的儿科、生物工程和药理学、遗传学部门以及拉霍亚研究中心附近的研究机构（即斯克里普斯研究所、拉霍亚过敏和免疫学研究所和桑福德-伯纳姆研究所）可以提供额外的培训。通过加州大学圣地亚哥分校临床和转化研究所、加州大学圣地亚哥分校创新治疗中心临床研究单位以及加州大学圣地亚哥分校医学中心和退伍军人医疗中心的临床设施，还可以获得丰富的患者样本资源和临床研究咨询资源。

DESCRIPTION (provided by applicant): The proposed program is designed to train postdoctoral researchers, at the level of MDs, MD/PhDs, and PhD scientists, interested in biomedical research in the area of rheumatic diseases. The training program will consist of a bench research laboratory experience of 12-36 months, under the close supervision of a mentor working on immunologic, molecular biologic, or biochemical problems relevant to the rheumatoid diseases, with an emphasis on generating novel research-based translational approaches to rheumatic diseases and ultimately, potential new targeted therapeutic interventions. Co-mentoring and team mentoring are features of the program, to mesh complementary skills and resources of more than one preceptor, in an individualized manner appropriate to the trainee and research project. All trainees will take courses in scientific ethic and scientific methodology. Other formal academic course work is available for those interested, at the discretion of the trainee and mentor. Training will be physicians, and MD/PhDs, who have completed one year of internship and two or more years of house staff training, usually in general internal medicine, or PhD scientists with an interest in devoting research efforts to subjects relevant to rheumatic diseases. Trainees will be chosen on the basis of their prior academic performance, research experience, publications, interviews, and recommendations from supervisors. Preference will be given to those with acknowledged research interests in rheumatologic and immunologic diseases, and demonstrated capacities in research. Four postdoctoral fellows will be selected to participate in the three-year fellowship. At the completio of the training, they will be prepared to compete successfully for full-time academic positions in medical schools or research institutes. We anticipate that the majority of the physicians and MD/PhDs will operate as rheumatologists within Departments of Medicine or as research scientists in academic centers or industry. The primary training unit will be the Rheumatology, Allergy and Immunology Division, in the Department of Medicine, University of California, San Diego, School of Medicine. At UCSD, training can be obtained in research laboratories located at the Biomedical Science, Leichtag, and Clinical Sciences Building located in La Jolla, or the San Diego Veterans Administration Medical Center also located adjoining the UCSD campus in La Jolla. Additional training is available in the UCSD Departments of Pediatrics, Bioengineering and Pharmacology, Genetics, and at nearby research institutions in the La Jolla research hub (i.e., the Scripps Research Institute, the La Jolla Institute of Allergy and Immunology, and the Sanford-Burnham Institute). Abundant patient sample resources and clinical research consultative resources are also available through the UCSD Clinical and Translational Research Institute, the UCSD Center for Innovative Therapy clinical research unit, and clinical facilities a UCSD Medical Center and the VA Medical Center.