Core C: Biogeochemistry Core Laboratory

核心C：生物地球化学核心实验室

• 批准号: 8659447
• 负责人: Joseph H Graziano
• 金额: $ 27.54万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8659447
• 关键词: Arsenic; Bangladesh; Biological Markers; Carbon; Chemistry; Child; Communities; Couples; Elements; Exhalation; Fluorescence; Generations; Hand; Health; Housing; Indium; Instruction; Iron; Laboratories; Longitudinal Studies; Manganese; Mass Spectrum Analysis; Measurement; Medical; Methodology; Methods; Particulate; Quality Control; Research Personnel; Resolution; Roentgen Rays; Sampling; Signal Recognition Particle; Solid; Testing; Translational Research; Universities; Urea; cohort; isoprostaglandin F2alpha type-III; liquid chromatography mass spectrometry; meetings; superfund site

PROJECT SUMMARY (See instructions); This analytical facility is housed at the Lamont-Doherty Earth Observatory of Columbia University. The Biogeochemistry Core will primarily support two biomedical projects and three non-biomedical projects, with additional support for the Community Engagement Core and the Research Translation Core. This support includes the analysis of ~24,000 groundwater samples by high-resolution inductively-couples mass spectrometry not only for As and Mn, on behalf of biomedical Projects 1 and 2, but also analysis of groundwater and sediment leaches for Na, Mg, Al, Si, P, S, K, Ca, Cr, Fe, Ni, Co, Cu, Zn, Mo, Cd, Sb, Ba, Pb and U on behalf of non-biomedical Projects 4, 5, 6, as well as the Community Engagement Core and the Research Translation Core. Core C also supports the analysis of exhaled breath condensate samples by liquid chromatography mass spectrometry for biomarkers collected for Project 2 and the determination of As speciation in a subset of groundwater and laboratory samples for the non-biomedical projects. For the analysis of the bulk chemistry of sediments from US Superfund sites and Bangladesh, the application of the latest generation of hand-held X-ray fluorescence analyzers will be systematically evaluated. Bulk organic carbon measurements in groundwater and sediment will also be supported under Core C.

项目总结(见说明)； 这个分析设施设在哥伦比亚大学的拉蒙特-多尔蒂地球天文台。生物地球化学核心将主要支持两个生物医学项目和三个非生物医学项目，并为社区参与核心和研究翻译核心提供额外支持。这项支助包括利用高分辨率电感耦合质谱仪分析约24,000个地下水样本，不仅代表生物医学项目1和2分析砷和锰，还代表非生物医学项目4、5、6以及社区参与核心和研究翻译核心分析地下水和沉积物中的Na、Mg、Al、Si、P、S、K、Ca、Cr、Fe、Ni、Co、铜、锌、钼、Cd、Sb、Ba、Pb和U。核心C还支持对呼出的呼气冷凝液样本进行液-色质谱分析，以确定为项目2收集的生物标记物，并确定非生物医学项目的地下水和实验室样本中的砷形态。对于来自美国超级基金和孟加拉国的沉积物的整体化学分析，将对最新一代手持X射线荧光分析仪的应用进行系统评估。核心C还将支持地下水和沉积物中的大量有机碳测量。