Midcareer Mentoring Award for Patient-Oriented Research in Aging

项目总结/摘要 该建议的目的是（1）使候选人能够进一步发展她的研究计划， 改善老年人的癌症筛查和预防;（2）将她的研究计划作为 一个指导对老龄化研究感兴趣的初级以患者为导向的研究人员的平台， 老年病学和医学亚专科。候选人是一名老年病学家，他建立了一个 高影响力的独立临床研究计划，资金充足，有杰出的出版物 记录在完成老年医学奖学金后的10年里，她已经成为一名 成功的导师的学生，研究员，和初级教师谁出版了高影响力的老龄化研究， 成功获得资助，并继续参与以病人为导向的老龄化研究。 候选人已经开发了广泛的研究组合，重点是癌症筛查的结果 在老年人中，他们试图通过更好地定义风险来提高癌症筛查的针对性， 福利，特别是作为预期寿命的函数。这项工作影响了筛选指南， 美国，他们利用这项研究建议筛查决策更多地关注预期寿命 而不是实际年龄，更好地认识到筛查的潜在危害。该提案将提供 候选人有保护的时间，以扩大她的研究在一个新的方向，重点是监测测试， 老年癌症幸存者的癌症复发。对老年癌症幸存者的监测也提出了类似的问题， 筛查，因为它可以通过发现仍然可以治疗的复发性癌症而使老年人受益， 过度治疗可能导致严重的发病率。本提案中的研究将为决策提供信息 通过更好地定义老年前列腺癌监测检测的风险和益处， 幸存者这个新方向保持了她的研究重点，同时与肿瘤学建立了新的合作。 候选人还将制定一个正式的指导计划，计划招聘，选拔， 发展和评估将成为老龄化研究领导者的学员。每个学员将 有一个有重点的职业发展计划，他们完成研究项目，并发展技能 需要成为老龄化研究的独立调查员。该提案将候选人的 指导计划到杰出的临床研究培训环境在加州大学旧金山分校，利用她 在老年医学部和临床和转化科学研究所（CTSI）的领导职位 职业发展（KL 2学者）计划，以招募更多对老龄化研究感兴趣的学员。

PROJECT SUMMARY/ABSTRACT The aims of this proposal are to (1) enable the candidate to further develop her research program focused on improving cancer screening and prevention in older adults and (2) use her research program as a platform for mentoring junior patient-oriented investigators interested in aging research, both within Geriatrics and within the medical subspecialties. The candidate is a Geriatrician who has established a high-impact independent clinical research program that is well funded with an outstanding publication record. In the 10 years since completing her Geriatrics fellowship she has established herself as a successful mentor of students, fellows, and junior faculty who have published high-impact aging research, become successfully funded, and continue to participate in patient-oriented research in aging. The candidate has developed an extensive research portfolio focused on the outcomes of cancer screening in elders that has sought to improve the targeting of cancer screening by better defining the risks and benefits, particularly as a function of life expectancy. This work has influenced screening guidelines in the U.S., which have used this research to recommend that screening decisions focus more on life expectancy than chronological age and better recognize the potential harms of screening. This proposal will provide the candidate with protected time to expand her research in a new direction focused on surveillance testing for cancer recurrence in older cancer survivors. Surveillance in older cancer survivors poses similar issues to screening in that it can potentially benefit elders by finding recurrent cancers when still treatable but also may cause substantial morbidity through overtreatment. The research in this proposal will inform decision making in this area by better defining the risks and benefits of surveillance testing in older prostate cancer survivors. This new direction maintains her research focus while building new collaborations with oncology. The candidate will also develop a formal mentoring program with plans for the recruitment, selection, development, and evaluation of mentees who will become leaders in aging research. Each mentee will have a focused career development plan in which they complete research projects and develop the skills needed to become independent investigators in aging research. This proposal integrates the candidate's mentoring program into the outstanding clinical research training environment at UCSF, leveraging her leadership positions in the Division of Geriatrics and the Clinical and Translational Science Institute (CTSI) Career Development (KL2 Scholars) Program to recruit more mentees interested in aging research.