Midcareer Mentoring Award for Patient-Oriented Research in Aging

以患者为导向的老龄化研究职业生涯中期指导奖

• 批准号: 8854012
• 负责人: Louise C. Walter
• 金额: $ 18.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8854012
• 关键词: Aftercare; Age; Aging; Area; Award; Benefits and Risks; Biopsy; Cancer Survivor; Caring; Characteristics; Clinical Data; Clinical Investigator; Clinical Research; Clinical Sciences; Collaborations; Comorbidity; Data; Decision Making; Development; Development Plans; Elderly; Electronic Health Record; Environment; Evaluation; Faculty; Fellowship; Frequencies; Funding; Geriatrics; Gleason Grade for Prostate Cancer; Grant; Guidelines; Image; Institutes; Leadership; Life; Life Expectancy; Malignant Neoplasms; Malignant neoplasm of prostate; Medical; Medicare claim; Mentors; Modeling; Monitor; Morbidity - disease rate; NCI Scholars Program; Outcome; Policies; Population; Positioning Attribute; Prevention; Prevention strategy; Process; Prostate-Specific Antigen; Prostatectomy; Public Health; Publications; Publishing; Radiation; Recommendation; Recruitment Activity; Recurrence; Recurrent Malignant Neoplasm; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Risk; Screening for Prostate Cancer; Screening for cancer; Staging; Testing; Time; Translational Research; Work; aged; base; cancer diagnosis; cancer prevention; cancer recurrence; career development; clinical decision-making; clinically relevant; colorectal cancer screening; curative treatments; improved; innovation; interest; men; novel; older men; oncology; patient oriented; patient oriented research; programs; randomized trial; screening; skills; student mentoring; surveillance study

PROJECT SUMMARY/ABSTRACT The aims of this proposal are to (1) enable the candidate to further develop her research program focused on improving cancer screening and prevention in older adults and (2) use her research program as a platform for mentoring junior patient-oriented investigators interested in aging research, both within Geriatrics and within the medical subspecialties. The candidate is a Geriatrician who has established a high-impact independent clinical research program that is well funded with an outstanding publication record. In the 10 years since completing her Geriatrics fellowship she has established herself as a successful mentor of students, fellows, and junior faculty who have published high-impact aging research, become successfully funded, and continue to participate in patient-oriented research in aging. The candidate has developed an extensive research portfolio focused on the outcomes of cancer screening in elders that has sought to improve the targeting of cancer screening by better defining the risks and benefits, particularly as a function of life expectancy. This work has influenced screening guidelines in the U.S., which have used this research to recommend that screening decisions focus more on life expectancy than chronological age and better recognize the potential harms of screening. This proposal will provide the candidate with protected time to expand her research in a new direction focused on surveillance testing for cancer recurrence in older cancer survivors. Surveillance in older cancer survivors poses similar issues to screening in that it can potentially benefit elders by finding recurrent cancers when still treatable but also may cause substantial morbidity through overtreatment. The research in this proposal will inform decision making in this area by better defining the risks and benefits of surveillance testing in older prostate cancer survivors. This new direction maintains her research focus while building new collaborations with oncology. The candidate will also develop a formal mentoring program with plans for the recruitment, selection, development, and evaluation of mentees who will become leaders in aging research. Each mentee will have a focused career development plan in which they complete research projects and develop the skills needed to become independent investigators in aging research. This proposal integrates the candidate's mentoring program into the outstanding clinical research training environment at UCSF, leveraging her leadership positions in the Division of Geriatrics and the Clinical and Translational Science Institute (CTSI) Career Development (KL2 Scholars) Program to recruit more mentees interested in aging research.

项目摘要/摘要 该提案的目的是（1）使候选人能够进一步发展其研究计划 在改善老年人的癌症筛查和预防和预防方面以及（2）将她的研究计划用作 指导初级以患者为导向的研究人员对衰老研究感兴趣的平台 老年医学和医学亚专业。候选人是一位老年医生，已经建立了 高影响力的独立临床研究计划，该计划具有杰出的出版物资助 记录。在完成她的老年医学研究金以来的10年中，她已经确立了自己的 出版了高影响力衰老研究的学生，研究员和初级教师的成功导师， 成功资助，并继续参与以患者为导向的衰老研究。 候选人已经开发了广泛的研究组合，重点是癌症筛查的结果 在试图通过更好地定义风险和 好处，特别是作为预期寿命的功能。这项工作影响了筛查指南 美国使用这项研究建议筛查决策更多地关注预期寿命 比年龄年龄，更好地认识到筛查的潜在危害。该建议将提供 有受保护时间的候选人将她的研究扩展到一个新的方向，重点是监视测试 癌症幸存者的癌症复发。老年癌症幸存者的监视提出了类似的问题 筛选它可能会通过在仍然可以治疗的情况下找到经常性癌症来使长者受益 通过过度治疗可能会导致大量发病。该提案中的研究将为决定提供信息 通过更好地定义较老前列腺癌监视测试的风险和好处来制作该领域 幸存者。这个新的方向在与肿瘤学建立新的合作时保持了她的研究重点。 候选人还将制定一项正式的指导计划，其中包含招聘，选择， 发展和评估将成为老龄化研究领导者的受训者。每个受训者都会 有一个专注的职业发展计划，他们完成研究项目并发展技能 需要成为衰老研究的独立研究人员。该提案整合了候选人的 指导计划进入UCSF的杰出临床研究培训环境，并利用她 老年医学和临床和转化科学研究所（CTSI）的领导职务 职业发展（KL2学者）计划，以招募更多对老龄化研究感兴趣的受训者。

项目成果

Cancer Screening Among Older Adults: a Geriatrician's Perspective on Breast, Cervical, Colon, Prostate, and Lung Cancer Screening.

• DOI: 10.1007/s11912-020-00968-x
• 发表时间: 2020-08-15
• 期刊: Current oncology reports
• 影响因子: 4.7
• 作者: Kotwal AA;Walter LC
• 通讯作者: Walter LC

Age and Prostate-Specific Antigen Level Prior to Diagnosis Predict Risk of Death from Prostate Cancer.

• DOI: 10.3389/fonc.2016.00157
• 发表时间: 2016
• 期刊: Frontiers in oncology
• 影响因子: 4.7
• 作者: MacKintosh FR;Sprenkle PC;Walter LC;Rawson L;Karnes RJ;Morrell CH;Kattan MW;Nawaf CB;Neville TB
• 通讯作者: Neville TB

Barrett's Esophagus Commonly Diagnosed in Elderly Men with Limited Life Expectancy.

巴雷特食管常见于预期寿命有限的老年男性。

• DOI: 10.1111/jgs.14409
• 发表时间: 2016
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Ko,MyungS;Fung,KathyZ;Shi,Ying;Espaldon,Roxanne;Shergill,Amandeep;Walter,LouiseC
• 通讯作者: Walter,LouiseC

Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society.

• DOI: 10.1001/jama.2015.12783
• 发表时间: 2015-10-20
• 期刊: JAMA
• 作者: Oeffinger KC;Fontham ET;Etzioni R;Herzig A;Michaelson JS;Shih YC;Walter LC;Church TR;Flowers CR;LaMonte SJ;Wolf AM;DeSantis C;Lortet-Tieulent J;Andrews K;Manassaram-Baptiste D;Saslow D;Smith RA;Brawley OW;Wender R;American Cancer Society
• 通讯作者: American Cancer Society