Midcareer Mentoring Award for Patient-Oriented Research in Aging

以患者为导向的老龄化研究职业生涯中期指导奖

• 批准号: 8223697
• 负责人: Louise C. Walter
• 金额: $ 18.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8223697
• 关键词: Aftercare; Age; Aging; Area; Award; Benefits and Risks; Biopsy; Cancer Survivor; Caring; Characteristics; Clinical Data; Clinical Investigator; Clinical Research; Clinical Sciences; Collaborations; Comorbidity; Data; Databases; Decision Making; Development; Development Plans; Elderly; Electronic Health Record; Environment; Evaluation; Faculty; Fellowship; Frequencies; Funding; Geriatrics; Gleason Grade for Prostate Cancer; Grant; Guidelines; Image; Institutes; Leadership; Life; Life Expectancy; Malignant Neoplasms; Malignant neoplasm of prostate; Medical; Medicare claim; Mentors; Modeling; Monitor; Morbidity - disease rate; NCI Scholars Program; Outcome; Policies; Population; Positioning Attribute; Prevention; Prevention strategy; Process; Prostate-Specific Antigen; Prostatectomy; Public Health; Publications; Publishing; Radiation; Recommendation; Recruitment Activity; Recurrence; Recurrent Malignant Neoplasm; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Risk; Screening for Prostate Cancer; Screening for cancer; Screening procedure; Staging; Students; Testing; Time; Translational Research; Work; aged; cancer diagnosis; cancer prevention; cancer recurrence; career development; clinical decision-making; clinically relevant; colorectal cancer screening; improved; innovation; interest; men; novel; older men; oncology; patient oriented; patient oriented research; programs; randomized trial; skills; surveillance study

DESCRIPTION (provided by applicant): The aims of this proposal are to (1) enable the candidate to further develop her research program focused on improving cancer screening and prevention in older adults and (2) use her research program as a platform for mentoring junior patient-oriented investigators interested in aging research, both within Geriatrics and within the medical subspecialties. The candidate is a Geriatrician who has established a high-impact independent clinical research program that is well funded with an outstanding publication record. In the 10 years since completing her Geriatrics fellowship she has established herself as a successful mentor of students, fellows, and junior faculty who have published high-impact aging research, become successfully funded, and continue to participate in patient-oriented research in aging. The candidate has developed an extensive research portfolio focused on the outcomes of cancer screening in elders that has sought to improve the targeting of cancer screening by better defining the risks and benefits, particularly as a function of life expectancy. This work has influenced screening guidelines in the U.S., which have used this research to recommend that screening decisions focus more on life expectancy than chronological age and better recognize the potential harms of screening. This proposal will provide the candidate with protected time to expand her research in a new direction focused on surveillance testing for cancer recurrence in older cancer survivors. Surveillance in older cancer survivors poses similar issues to screening in that it can potentially benefit elders by finding recurrent cancers when still treatable but also may cause substantial morbidity through overtreatment. The research in this proposal will inform decision making in this area by better defining the risks and benefits of surveillance testing in older prostate cancer survivors. This new direction maintains her research focus while building new collaborations with oncology. The candidate will also develop a formal mentoring program with plans for the recruitment, selection, development, and evaluation of mentees who will become leaders in aging research. Each mentee will have a focused career development plan in which they complete research projects and develop the skills needed to become independent investigators in aging research. This proposal integrates the candidate's mentoring program into the outstanding clinical research training environment at UCSF, leveraging her leadership positions in the Division of Geriatrics and the Clinical and Translational Science Institute (CTSI) Career Development (KL2 Scholars) Program to recruit more mentees interested in aging research. PUBLIC HEALTH RELEVANCE: This proposal will have unique public health importance because (1) it will increase mentoring of new clinical investigators interested in conducting research to improve care for the rapidly growing elderly population, and (2) it will inform national guidelines and clinical decision-making by better defining the risks and benefits of prostate-specific antigen (PSA) surveillance practices in elderly prostate cancer survivors.

描述（由申请人提供）：该提案的目的是（1）使候选人能够进一步开发她的研究计划，重点是改善老年人的癌症筛查和预防，（2）将她的研究计划用作指导初级患者面向患者的研究人员的平台，以培养老年人和医学领域内的衰老研究人员。候选人是一位老年医生，他建立了一项高影响力的独立临床研究计划，并获得了出色的出版记录。自完成老年医学奖学金以来的10年中，她成为了一位成功的学生，研究员和初级教职员工的导师，他们发表了高影响力的老龄化研究，成功地资助了资金，并继续参与以患者为导向的衰老研究。候选人已经开发了广泛的研究组合，重点是长辈癌症筛查的结果，他们试图通过更好地定义风险和益处来改善癌症筛查的靶向，尤其是根据预期寿命的函数。这项工作影响了美国的筛查指南，这些指南利用这项研究建议筛查决策更关注预期寿命，而不是按时间顺序排列的年龄，并更好地认识到筛查的潜在危害。该提案将为候选人提供受保护的时间，将她的研究扩展到新的方向，重点是监测老年癌症幸存者的癌症复发。老年癌症幸存者的监视与筛查相似，因为它在仍然可以治疗时可以通过发现复发性癌症来使长者受益，但也可能通过过度治疗引起大量发病率。该提案中的研究将通过更好地定义老年前列腺癌幸存者监视测试的风险和好处来为这一领域的决策提供信息。这个新的方向在与肿瘤学建立新的合作时保持了她的研究重点。候选人还将制定一项正式的指导计划，并通过招募，选择，开发和评估将成为老龄化研究领导者的招聘，选择，开发和评估。每个受训者都将制定一个专注的职业发展计划，在该计划中，他们完成研究项目并发展成为老龄化研究中独立研究人员所需的技能。该建议将候选人的指导计划纳入UCSF的杰出临床研究培训环境中，以利用她在老年医学和临床和转化科学研究所（CTSI）职业发展（KL2学者）计划中的领导地位，以招募更多对老化研究感兴趣的指导者。 PUBLIC HEALTH RELEVANCE: This proposal will have unique public health importance because (1) it will increase mentoring of new clinical investigators interested in conducting research to improve care for the rapidly growing elderly population, and (2) it will inform national guidelines and clinical decision-making by better defining the risks and benefits of prostate-specific antigen (PSA) surveillance practices in elderly prostate cancer survivors.