Rocky Mountain Neurological Disorders Core

落基山神经疾病核心

• 批准号: 8427300
• 负责人: WILLIAM J BETZ
• 金额: $ 19.74万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8427300
• 关键词: Area; Biophysics; Charge; Computers and Advanced Instrumentation; Education; Electron Microscope; Electron Microscopy; Fees; Fluorescence; Fluorescence Microscopy; Fluorescence Spectroscopy; Funding; Generations; Goals; Health Sciences; Heating; Image; Investments; Kidney; Lighting; Medicine; Microscope; Microscopy; National Institute of Neurological Disorders and Stroke; Optics; Physiology; Research; Schedule; Services; Specialist; Spectrum Analysis; Staging; Technical Expertise; Training; charge coupled device camera; fluorescence microscope; instrument; instrumentation; interest; light microscopy; medical schools; nervous system disorder; new technology; photoactivation; photonics; professor; ranpirnase; second harmonic

CI. 1 Rationale. The Light Microscopy Core (LMC; see www.uchsc.edu/liqhtmicroscopv) has proven to be a highly useful, successful multi-user (42 total, see Appendix Item 4) facility offering five state-of-the-art instruments. New technologies continually emerge, and we have an exciting opportunity nearly to double the size of the LMC with new, advanced instrumentation and technical expertise. We propose to combine with a facility in the Renal Division of the Department of Medicine, which has been developed by Dr. Moshe Levi (Professor of Medicine, Physiology and Biophysics; Vice Chair of Medicine for Research). Until recently, the two facilities were entirely separate, in terms of instrumentation, space, users, administration, and funding. This situation arose because the Health Sciences Center built and moved to an entirely new $2.2B campus. The move occurred over about six years and was completed in January 2009. The LMC was one of the first to move, while the Department of Medicine Core was one of the last. Thus, for about five years the two cores operated entirely independently. Now that they are on the same campus (in adjacent buildings connected by a heated bridge), we have an opportunity to combine them, and make available to RMNDC users new instruments, at no additional chiarge to them. In addition, a campus-wide quinquennial Research Retreat is scheduled for November, 2009, and Light Microscopy has been selected by the central administration as one of three areas identified for special consideration. The likely upshot will be significant investment of intramural funds by the School of Medicine in the new, combined core. Dr. Betz is co-chair with Dr. Levi of the committee charged with presenting a long range plan at the Retreat. While still in the planning stages, a major goal is the purchase of new advanced instruments. Already his committee has identified several instruments of interest to multiple users (e.g., advanced spinning disk microscope with microlens illumination, STimulated Emission Depletion (STED) microscope).

CI。 1 基本原理。光学显微镜核心（LMC；参见 www.uchsc.edu/liqhtmicroscopv）已被证明是 非常有用、成功的多用户（总共 42 个，参见附录第 4 项）设施，提供五种最先进的仪器。新技术不断涌现，我们有一个令人兴奋的机会，可以通过新的、先进的仪器和技术专业知识将 LMC 的规模扩大近一倍。我们建议与医学系肾脏科的一个设施相结合，该设施由 Moshe Levi 博士（医学、生理学和生物物理学教授；医学研究副主席）开发。直到最近，这两个设施在仪器、空间、用户、管理和资金方面都是完全独立的。出现这种情况是因为健康科学中心建造并搬到了一个全新的 $2.2B 园区。此次搬迁历时约六年，于 2009 年 1 月完成。LMC 是最早搬迁的部门之一，而医学核心系是最后搬迁的部门之一。因此，在大约五年的时间里，两个核心 完全独立运作。现在它们位于同一个园区（在通过加热桥连接的相邻建筑物中），我们有机会将它们组合起来，并向 RMNDC 用户提供新仪器，而无需向他们提供额外的服务。此外，计划于 2009 年 11 月在全校范围内开展五年一次的研究静修活动，光学显微镜已被中央管理部门选为研究静修活动之一。 确定需要特别考虑的三个领域。可能的结果将是医学院对新的合并核心进行大量校内资金投资。贝茨博士与莱维博士共同担任委员会的联合主席，负责在静修会上提出长期计划。虽然仍处于规划阶段，但主要目标是 购买新的先进仪器。他的委员会已经确定了多个用户感兴趣的几种仪器（例如，具有微透镜照明的先进旋转圆盘显微镜、STimulated Emission Depletion (STED) 显微镜）。