Rocky Mountain Neurological Disorders Core

落基山神经疾病核心

• 批准号: 8214022
• 负责人: WILLIAM J BETZ
• 金额: $ 20.06万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8214022
• 关键词: Area; Biophysics; Charge; Computers and Advanced Instrumentation; Education; Electron Microscope; Electron Microscopy; Fees; Fluorescence; Fluorescence Microscopy; Fluorescence Spectroscopy; Funding; Generations; Goals; Health Sciences; Heating; Image; Investments; Kidney; Lighting; Medicine; Microscope; Microscopy; National Institute of Neurological Disorders and Stroke; Optics; Physiology; Research; Schedule; Services; Specialist; Spectrum Analysis; Staging; Technical Expertise; Training; charge coupled device camera; fluorescence microscope; instrument; instrumentation; interest; light microscopy; medical schools; nervous system disorder; new technology; photoactivation; photonics; professor; ranpirnase; second harmonic

CI. 1 Rationale. The Light Microscopy Core (LMC; see www.uchsc.edu/liqhtmicroscopv) has proven to be a highly useful, successful multi-user (42 total, see Appendix Item 4) facility offering five state-of-the-art instruments. New technologies continually emerge, and we have an exciting opportunity nearly to double the size of the LMC with new, advanced instrumentation and technical expertise. We propose to combine with a facility in the Renal Division of the Department of Medicine, which has been developed by Dr. Moshe Levi (Professor of Medicine, Physiology and Biophysics; Vice Chair of Medicine for Research). Until recently, the two facilities were entirely separate, in terms of instrumentation, space, users, administration, and funding. This situation arose because the Health Sciences Center built and moved to an entirely new $2.2B campus. The move occurred over about six years and was completed in January 2009. The LMC was one of the first to move, while the Department of Medicine Core was one of the last. Thus, for about five years the two cores operated entirely independently. Now that they are on the same campus (in adjacent buildings connected by a heated bridge), we have an opportunity to combine them, and make available to RMNDC users new instruments, at no additional chiarge to them. In addition, a campus-wide quinquennial Research Retreat is scheduled for November, 2009, and Light Microscopy has been selected by the central administration as one of three areas identified for special consideration. The likely upshot will be significant investment of intramural funds by the School of Medicine in the new, combined core. Dr. Betz is co-chair with Dr. Levi of the committee charged with presenting a long range plan at the Retreat. While still in the planning stages, a major goal is the purchase of new advanced instruments. Already his committee has identified several instruments of interest to multiple users (e.g., advanced spinning disk microscope with microlens illumination, STimulated Emission Depletion (STED) microscope).

CI. 1理由。光学显微镜核心（LMC;见www.uchsc.edu/liqhtmicroscopv）已被证明是一种 非常有用，成功的多用户（共42个，见附录项目4）设施，提供五种最先进的仪器。新技术不断涌现，我们有一个令人兴奋的机会，通过新的先进仪器和技术专长，将LMC的规模扩大近一倍。我们建议将联合收割机与医学系肾脏科的一个设施相结合，该设施由Moshe Levi博士（医学、生理学和生物物理学教授;医学研究副主席）开发。直到最近，这两个设施在仪器、空间、用户、管理和资金方面都是完全分开的。出现这种情况是因为健康科学中心建成并搬到了一个全新的22亿美元的校园。搬迁历时约六年，于2009年1月完成。LMC是最早行动的，而医学核心系是最后行动的。因此，在大约五年的时间里， 完全独立运作。现在，他们在同一个校园（在相邻的建筑物连接的加热桥），我们有机会联合收割机，并提供给RMNDC用户新的仪器，在没有额外的chiarge给他们。此外，2009年11月将举办一个全校范围的五年一次的研究务虚会，光学显微镜已被中央政府选为其中之一。 三是要特别考虑的问题。可能的结果将是医学院在新的合并核心中投入大量的校内资金。贝茨博士与利维博士共同担任委员会主席，负责在务虚会上提出一项长期计划。虽然仍处于规划阶段，但主要目标是 购买新的先进仪器。他的委员会已经确定了多个用户感兴趣的几种工具（例如，具有微透镜照明的高级旋转盘显微镜、模拟发射损耗（STED）显微镜）。