Training Program in Integrative Membrane Biology

描述(由申请人提供)：综合膜生物学培训计划(TPIMB)旨在培训生物膜的生物学、生物物理学和生理学方面的博士前学生。现在已经是第三十年了，TPIMB继续在马里兰大学医学院(UM SOM)分子、细胞和系统生物学的界面上领导跨学科培训，专注于细胞膜和细胞内膜在调节和整合细胞功能及其与环境相互作用中的作用。该计划的指导思想是，对膜生物物理和生理学以及基于膜的信号级联的研究可以为细胞和组织的生物学提供独特的见解，无论是健康状态还是疾病状态。 TPIMB的教职员工，现在有37人，资金充足，高度互动，致力于指导学习与膜生物学相关的广泛学科的学生。导师是根据他们的兴趣、外部支持和对指导的承诺来选择的。学员的选择也基于他们的兴趣，以及研究生课程成绩、标准化考试成绩、推荐和以前的研究经验。UM SOM所有以实验室研究为基础的研究生教育都需要一门细胞和分子生物学的核心课程。学生还需要参加一系列关于膜生物化学和生物物理学的高级课程，以及关于膜缺陷与人类疾病之间的联系的课程，以及一门研究伦理课程。他们还学习细胞和系统生理学、药理学或神经科学的入门和/或高级课程。学员定期参加以学生为导向的活动，如研讨会、每月聚会和年度务虚会。UM SOM通过为教师工资、学生额外津贴以及为TPIMB的常规活动提供资金，慷慨地支持这一计划。NIH目前的资金支持了7名学员，但许多人遵循我们的课程，在没有支持的情况下参加我们的活动。我们在研究生培养方面所做的努力，取得了成功 最近的招聘，以及UM SOM稳定的联邦资金表明，继续为我们的项目提供资金是合理的。在持续的支持下，TPIMB的教职员工和学生可以继续带头努力，将细胞和系统生物学方面的培训整合到UM SOM。

DESCRIPTION (provided by applicant): The Training Program in Integrative Membrane Biology (TPIMB) is designed to train predoctoral students in the biology, biophysics, and physiology of biological membranes. Now in its 3rd decade, the TPIMB continues to lead the effort in interdisciplinary training at the interface of molecular, cell, and systems biology at th University of Maryland School of Medicine (UM SOM), by focusing on the role of the cell membrane and intracellular membranes in mediating and integrating the functions of cells and their interactions with the environment. The program is guided by the idea that studies of membrane biophysics and physiology, and of membrane-based signaling cascades, can provide unique insights into the biology of cells and tissues, in both healthy and diseased states. The faculty of the TPIMB, now numbering 37 individuals, are well funded, highly interactive, and devoted to mentoring students studying a broad range of subjects related to Membrane Biology. Mentors are selected for their interests, extramural support, and commitment to mentoring. Trainees are also selected based on their interests, as well as graduate course grades, standardized test scores, recommendations, and previous research experience. A core course in Cell and Molecular Biology, common to all laboratory research- based graduate education at UM SOM, is required. Students are also required to take a series of upper level courses on membrane biochemistry and biophysics, and on links between membrane defects and human diseases, as well as a class in research ethics. They also take introductory and/or advanced courses in Cellular and Systems Physiology, Pharmacology, or Neuroscience. Trainees participate regularly in student-oriented activities, such as seminars, monthly get-togethers, and an annual retreat. The UM SOM supports this program generously through contributions to faculty salary, additional stipends for students, and funds for the TPIMB's regular activities. Current NIH funding supports 7 trainees but leaves many following our curriculum and taking part in our activities without support. The strength of our graduate training efforts, successes in recent recruitment, and the stable federal funding at the UM SOM suggest that continued funding for our program is well justified. With continued support, the faculty and students in the TPIMB can continue to spearhead the effort to integrate training in cell and systems biology at the UM SOM.