The Norwegian Mother And Child Study: Environmental Specimen Collection

挪威母子研究：环境样本收集

• 批准号: 8929716
• 负责人: Matthew Longnecker
• 金额: $ 45.67万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929716
• 关键词: Attention deficit hyperactivity disorder; Autistic Disorder; Biological; Birth; Blood; C-reactive protein; Cerebral Palsy; Child; Childhood; Cohort Studies; Collaborations; Collection; DNA Methylation; Data; Data Collection; Development; Disease; Drug Kinetics; Enrollment; Environmental Exposure; Epidemiology; Fathers; Fetus; Finding by Cause; Future; Growth; Hand; Health; Hormones; Infection; Learning; Lipids; Measures; Medical; Metabolic; Mothers; National Institute of Environmental Health Sciences; Organophosphates; Outcome; Paper; Pesticides; Physical activity; Pilot Projects; Plasma; Pre-Eclampsia; Predisposition; Pregnancy; Protocols documentation; Publications; Publishing; Questionnaires; Renal function; Reporting; Research Personnel; Risk; Risk Factors; Scientist; Series; Serum; Simulate; Specimen; System; Testing; Thyroid Gland; Trace Elements; Triclosan; Umbilical Cord Blood; Urine; Whole Blood; Woman; Women' s Group; base; bisphenol A; cohort; disorder risk; in utero; inflammatory marker; insight; interest; pesticide exposure; phthalates; sample collection

The Norwegian Mother and Child Cohort Study (MoBa) is an ongoing prebirth cohort study. Enrollment was completed in 2008 resulting in 106,980 pregnancies in the study. The study is based on questionnaires completed by the mother and father, and biological specimens are collected from the mother, father and child. The main purpose of the study is to find causes of diseases. NIEHS is providing partial support for the study, and in 2002 expanded the data collection protocol to include collection of more biologic specimens from the mothers during the 17th week of pregnancy (additional serum, a specimen of whole blood collected in a trace-element free container, and urine). These specimens will enhance the ability to examine the relation of environmental exposures in relation to various health outcomes in the children and their mothers. As of April 30, 2009, 77,104 subjects had provided blood and urine that was collected in conjunction with NIEHS. We added to the MoBa protocol the collection additional urine specimens in pregnancy, at weeks 23 and 29, for a subset of women. 690 women have a complete set of three urine specimens from pregnancy. We have learned that the preservative used in the collection of the urine specimens contaminated them with free bisphenol A, and also makes the specimens difficult to analyze for other analytes such as organophosphate pesticide metabolites. This information will be of great use as we plan future studies. We published one report this year about the contamination issue. Future studies seeking to quantitate bisphenol A will need to measure total and free BPA, so that conjuated BPA can be estimated. This year, in collaboration with Dr. Stephanie Engel at UNC, we conducted pilot studies and determined that the specimens can be analyzed for organophosphate pesticide metabolites and phthalates, and we are now collaborating with her on full studies of these agents in relation to attention-deficit hyperactivity disorder in MoBa children. We also were successful in using the urines in a study of the reliability of measuring triclosan during pregnancy, which was published this year. We also have studied the maternal plasma concentration of perfluoralkyl substances (PFAS) in relation to various outcomes among women in the MoBa cohort. This year we published one paper each on PFAS and a) preeclampsia, b) lipids, and )thyroid simulating hormone. An additional paper, based on the same group of women, is about physical activity in pregnancy and plasma levels of C-reactive protein, a marker of inflammation (in press and not listed below). We are planning a series of new studies, using the data in hand, to examine a) the reliability of the plasma levels over a period of several years, b) exposure in relation to child growth, and c) exposure in relation to infections in childhood. Because of our interest in perfluoroalkyl substances, we have also been collaborating on studies of the pharmacokinetics of these compounds, which provide insight into epidemiologic findings. Our publication this year by Morken et al. was related to this subproject; the Morken paper was about the relation of kidney function during pregnancy to the size of the fetus. Scientists at NIEHS are developing several studies that will be nested within MoBa. A list of the studies currently planned includes: Risk factors for cerebral palsy, Determinants of DNA methylation in cord blood, Organophosphate Pesticide Exposure and Risk of Autism, and additional studies on perfluorinated compound exposure and various aspects of health.

挪威母婴队列研究（MoBa）是一项正在进行的产前队列研究。该研究于2008年完成登记，共有106980人怀孕。该研究基于父母完成的问卷调查，并从母亲，父亲和孩子身上收集生物标本。这项研究的主要目的是找出疾病的原因。NIEHS正在为这项研究提供部分支持，并于2002年扩大了数据收集方案，包括从怀孕第17周的母亲那里收集更多的生物标本（额外的血清、在无微量元素容器中收集的全血标本和尿液）。这些标本将加强检查环境暴露与儿童及其母亲各种健康结果之间关系的能力。截至2009年4月30日，77,104名受试者提供了与NIEHS联合收集的血液和尿液。