Building Interdisciplinary Research Careers in Women's Health

描述（由申请人提供）：范德比尔特BIRCWH学者计划的目标是增加准备充分的调查人员，致力于推进对妇女健康的知识库。我们的科学重点是将对妇女健康和性/性别差异的研究整合到整个科学领域蓬勃发展的研究计划中，以便为女孩和妇女实现个性化的预防，诊断和治疗。我们正在建立卓越的研究传统，包括正在进行的上海妇女健康研究，有75，000多名参与者，一个前瞻性的基于社区的7，190名妇女的妊娠队列，与超过132，000名患者的临床数据相关的DNA样本，大型组织和生物标志物库，20年的医疗补助数据，以及许多其他在实验室内外进行基础性发现的大型项目的例子。我们的16位前任和现任学者在狼疮的免疫学方面，ICU护理结果的性别差异，不良妊娠结局中种族差异的遗传基础，妊娠期间暴露于阿片类药物的人群水平模式以及铁平衡对艾滋病毒疾病轨迹的影响等内容领域进行研究。校友离开该计划的平均17总出版物，迄今已获得超过900万美元的校外研究支持。BIRCWH学者扎根于女性健康和性别差异研究的基础，准备领导独立和合作的研究项目，经过培训，有效地部署创新的跨学科方法来攻击和解决问题，并致力于追求研究，使个性化的护理更接近现实。学者是通过对早期职业教师的申请进行竞争性审查而选出的。在结构化的跨学科指导背景下，培训是针对研究者个人的，并由PI监督， 项目主任和助理项目主任（每个前BIRCWH学者）。BIRCWH计划资源通过无数的机构资源进一步增强，以确保我们的研究人员茁壮成长。学者组成一个指导小组，参加定期的BIRCWH工作进展报告和研讨会，每年接受正式评估，与其他K-获奖者一起参加每月两次的职业发展研讨会系列，并定期接触负责任的研究行为的案例研究。他们可以获得：1）一系列核心实验室和资源; 2）生物统计学咨询; 3）手稿准备工作组; 4）完成产品的技术编辑; 5）与专家一起审查科学思想，研究设计和目标的工作室; 6）强大的校内试点和可行性资助;以及7）资助写作支持，包括资助研讨会，资助图书馆和模拟研究部分。工具到位，以评估学员和导师，并不断提高我们的计划。咨询委员会和两年一次的外部审查提供进一步监督。结合这些努力，确保我们精心培养下一代女性健康研究人员的卓越。

DESCRIPTION (provided by applicant): The goal of the Vanderbilt BIRCWH Scholars Program is to increase the pool of well-prepared investigators dedicated to advancing knowledge about women's health. Our scientific focus is to integrate the study of women's health and sex/gender differences into thriving research programs across the scientific spectrum, in order to actualize personalized prevention, diagnostics, and therapeutics for girls and women. We are building on a tradition of research excellence that includes the ongoing Shanghai Women's Health Study with 75,000+ participants, a prospective community-based pregnancy cohort of 7,190 women, DNA samples linked with clinical data for more than 132,000 patients, large tissue and biomarker banks, two decades of Medicaid data with record linkage, and numerous other examples of large scale programs making fundamental discoveries inside and outside the lab. Our 16 former and current scholars conduct research in content areas as diverse as immunologic aspects of lupus, gender differences in outcomes of ICU care, genetic underpinnings of racial disparities in adverse pregnancy outcomes, population-level patterns of exposure to opiates in pregnancy, and influence of iron balance on HIV disease trajectory. Alumni leave the program with an average of 17 total publications and to date have been awarded more than $9 million in extramural research support. BIRCWH Scholars are grounded in the fundamentals of women's health and sex differences research, prepared to lead independent and collaborative research programs, trained to effectively deploy innovative interdisciplinary approaches to attack and solve problems, and committed to pursuing research that brings individualized care for women closer to reality. Scholars are selected by competitive review of applications from among early career faculty. Training is tailored to the individual investigator, in the context of structured interdisciplinary mentorship, and is overseen by the PI, Program Director and Assistant Program Director (each a former BIRCWH Scholar). BIRCWH program resources are further enhanced by myriad institutional resources that ensure our researchers thrive. Scholars form a mentoring panel, participate in regular BIRCWH work-in- progress presentations and seminars, receive formal evaluation each year, attend twice-monthly career development seminar series with other K-awardees, and are regularly exposed to case studies on responsible conduct of research. They have access to: 1) an array of core labs and resources; 2) biostatistics consultations; 3) manuscript preparation work groups; 4) technical editing of completed products; 5) studios with experts to vet scientific ideas, research designs, and aims; 6) robust intramural pilot and feasibility funding; and 7) grant writing support includin grant workshops, a funded grant library, and mock study sections. Tools are in place to evaluate both mentees and mentors and to continuously enhance our program. Further oversight is provided by an Advisory Committee and biennial external reviews. Combined these efforts assure we carefully foster excellence in the next generation of women's health researchers.