ABCD-USA Consortium: Research Project
ABCD-美国联盟:研究项目
基本信息
- 批准号:9053241
- 负责人:
- 金额:$ 62.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-30 至 2020-05-31
- 项目状态:已结题
- 来源:
- 关键词:10 year oldAddressAdolescenceAdolescentAdolescent DevelopmentAgeAlcohol or Other Drugs useAlcoholsAmericanBehaviorBehavior TherapyBehavioralBehavioral GeneticsBioinformaticsBiologicalBiological AssayBrainBrain imagingCharacteristicsChildChild DevelopmentChildhoodChronobiologyClinicalClinical assessmentsCommunitiesDataData AnalysesData CollectionDevelopmentDevicesDoseElementsEnsureEnvironmentEpidemiologyEvaluationEventFamilyFutureGeneticGoalsHumanHuman DevelopmentIndividualInformaticsInternationalInterviewLeadLifeLinkLongitudinal StudiesMagnetic Resonance ImagingMarijuanaMeasuresMental DepressionMental HealthMethodologyMethodsMonitorNeurobiologyNeurocognitionNeurocognitiveNeuropsychological TestsOnline SystemsOutcomeParticipantPathway interactionsPatient Self-ReportPatternPhenotypePopulationProceduresProcessPsychopathologyQuality ControlQuestionnairesRecording of previous eventsRecruitment ActivityReportingResearchResearch PersonnelResearch Project GrantsResourcesRiskRoleSamplingSiteSleepSocial FunctioningSocioeconomic StatusStandardizationSurveysSymptomsTechnologyTimeTwin Multiple BirthUncertaintyWristYouthactigraphyadolescent substance useage relatedawakebasebehavioral healthcognitive developmentcognitive testingcohesioncomputerizeddesignearly onsetemerging adultexperiencehandheld mobile devicehigh riskmarijuana usermisuse of prescription only drugsneuroimagingnovelpsychological outcomespublic health relevanceresponsesexsuccesstemporal measurementtime usetrend
项目摘要
DESCRIPTION (provided by applicant): Adolescence is a critical neurodevelopmental period associated with dramatic increases in rates of substance use. Identifying the pathways to substance use and its effects on child and adolescent development is critically important, as the effects of substance use during ongoing maturation likely have long-lasting effects on brain functioning and behavioral, health, and psychological outcomes. This Research Project Site application from SRI International is in response to RFA-DA-15-015 as part of the ABCD-USA Consortium (10/13), to prospectively determine the neurodevelopmental and behavioral predictors and consequences of substance use on children and adolescents. A representative community sample of 550 9-10 year olds enriched for high- risk characteristics will be recruited, contributing to the sample of 11,111 to be collected from 11 hubs across the ABCD-USA Consortium. All participants will undergo a comprehensive baseline assessment, including state-of-the-art brain imaging, comprehensive neuropsychological testing, bioassays, mobile monitoring and careful assessment of substance use, environment, psychopathological symptoms, and social functioning every 2 years. Interim annual interviews and quarterly web-based assessments will provide refined temporal resolution of behaviors, development, and life events with minimal participant burden. These Consortium-wide data obtained during the course of this project will elucidate: 1) the effects of substance use patterns on the adolescent brain; 2 the effects of substance use on behavioral and health outcomes; 3) the bidirectional relationship between psychopathology and substance use patterns; 4) the effects of individual genetic, behavioral, neurobiological, and environmental differences on risk profiles and substance use outcomes; and 5) the "gateway interactions" between use of different substances. Our project focuses on the sleep and chronobiology data collected across the consortium, both with questionnaires and periodic assessment with wearable wrist trackers. Our aims are to assess sleep behavior and chronotype as predictors of subsequent substance use, and to investigate the effects of current substance use on sleep characteristics in adolescents. We will also conduct exploratory analyses to determine the effect of marijuana usage on sleep, to evaluate relationships between sleep and chronobiology variables, substance use and development of depression; and to investigate genetic and environmental contributions to associations between sleep characteristics, chronotype and substance use in twins. The combination of careful assessment of subjective and objective sleep and chronotype, detailed evaluation of substance use patterns and sensitive clinical measures will provide a unique resource for the scientific community, and help guide age-appropriate behavioral interventions.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Fiona C Baker其他文献
Fiona C Baker的其他文献
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{{ truncateString('Fiona C Baker', 18)}}的其他基金
Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescents
与流行病相关的社会联系中断对青少年大脑和情绪健康的影响
- 批准号:
10681759 - 财政年份:2022
- 资助金额:
$ 62.87万 - 项目类别:
Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescents
与流行病相关的社会联系中断对青少年大脑和情绪健康的影响
- 批准号:
10374459 - 财政年份:2022
- 资助金额:
$ 62.87万 - 项目类别:
Emotion Regulation and Sleep in Alcohol Use Disorder
酒精使用障碍中的情绪调节和睡眠
- 批准号:
10254381 - 财政年份:2020
- 资助金额:
$ 62.87万 - 项目类别:
Emotion Regulation and Sleep in Alcohol Use Disorder
酒精使用障碍中的情绪调节和睡眠
- 批准号:
10041719 - 财政年份:2020
- 资助金额:
$ 62.87万 - 项目类别:
10/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT SRI
10/21 ABCD-美国联盟:SRI 研究项目现场
- 批准号:
10596278 - 财政年份:2015
- 资助金额:
$ 62.87万 - 项目类别:
10/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT SRI
10/21 ABCD-美国联盟:SRI 研究项目现场
- 批准号:
9981974 - 财政年份:2015
- 资助金额:
$ 62.87万 - 项目类别:
10/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT SRI
10/21 ABCD-美国联盟:SRI 研究项目现场
- 批准号:
10376294 - 财政年份:2015
- 资助金额:
$ 62.87万 - 项目类别:
Impact of the Coronavirus Pandemic on Alcohol Consumption and Mental Health in Young People
冠状病毒大流行对年轻人饮酒和心理健康的影响
- 批准号:
10171298 - 财政年份:2012
- 资助金额:
$ 62.87万 - 项目类别:
National Consortium on Alcohol and NeuroDevelopment in Adolescence - SRI International Research Project Site (NCANDA-SRI)
国家青少年酒精与神经发育联盟 - SRI 国际研究项目网站 (NCANDA-SRI)
- 批准号:
10471641 - 财政年份:2012
- 资助金额:
$ 62.87万 - 项目类别:
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