ABCD-USA Consortium: Research Project

ABCD-美国联盟：研究项目

• 批准号: 9053241
• 负责人: Fiona C Baker
• 金额: $ 62.87万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9053241
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adolescent Development; Age; Alcohol or Other Drugs use; Alcohols; American; Behavior; Behavior Therapy; Behavioral; Behavioral Genetics; Bioinformatics; Biological; Biological Assay; Brain; Brain imaging; Characteristics; Child; Child Development; Childhood; Chronobiology; Clinical; Clinical assessments; Communities; Data; Data Analyses; Data Collection; Development; Devices; Dose; Elements; Ensure; Environment; Epidemiology; Evaluation; Event; Family; Future; Genetic; Goals; Human; Human Development; Individual; Informatics; International; Interview; Lead; Life; Link; Longitudinal Studies; Magnetic Resonance Imaging; Marijuana; Measures; Mental Depression; Mental Health; Methodology; Methods; Monitor; Neurobiology; Neurocognition; Neurocognitive; Neuropsychological Tests; Online Systems; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Phenotype; Population; Procedures; Process; Psychopathology; Quality Control; Questionnaires; Recording of previous events; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Sampling; Site; Sleep; Social Functioning; Socioeconomic Status; Standardization; Surveys; Symptoms; Technology; Time; Twin Multiple Birth; Uncertainty; Wrist; Youth; actigraphy; adolescent substance use; age related; awake; base; behavioral health; cognitive development; cognitive testing; cohesion; computerized; design; early onset; emerging adult; experience; handheld mobile device; high risk; marijuana user; misuse of prescription only drugs; neuroimaging; novel; psychological outcomes; public health relevance; response; sex; success; temporal measurement; time use; trend

 DESCRIPTION (provided by applicant): Adolescence is a critical neurodevelopmental period associated with dramatic increases in rates of substance use. Identifying the pathways to substance use and its effects on child and adolescent development is critically important, as the effects of substance use during ongoing maturation likely have long-lasting effects on brain functioning and behavioral, health, and psychological outcomes. This Research Project Site application from SRI International is in response to RFA-DA-15-015 as part of the ABCD-USA Consortium (10/13), to prospectively determine the neurodevelopmental and behavioral predictors and consequences of substance use on children and adolescents. A representative community sample of 550 9-10 year olds enriched for high- risk characteristics will be recruited, contributing to the sample of 11,111 to be collected from 11 hubs across the ABCD-USA Consortium. All participants will undergo a comprehensive baseline assessment, including state-of-the-art brain imaging, comprehensive neuropsychological testing, bioassays, mobile monitoring and careful assessment of substance use, environment, psychopathological symptoms, and social functioning every 2 years. Interim annual interviews and quarterly web-based assessments will provide refined temporal resolution of behaviors, development, and life events with minimal participant burden. These Consortium-wide data obtained during the course of this project will elucidate: 1) the effects of substance use patterns on the adolescent brain; 2 the effects of substance use on behavioral and health outcomes; 3) the bidirectional relationship between psychopathology and substance use patterns; 4) the effects of individual genetic, behavioral, neurobiological, and environmental differences on risk profiles and substance use outcomes; and 5) the "gateway interactions" between use of different substances. Our project focuses on the sleep and chronobiology data collected across the consortium, both with questionnaires and periodic assessment with wearable wrist trackers. Our aims are to assess sleep behavior and chronotype as predictors of subsequent substance use, and to investigate the effects of current substance use on sleep characteristics in adolescents. We will also conduct exploratory analyses to determine the effect of marijuana usage on sleep, to evaluate relationships between sleep and chronobiology variables, substance use and development of depression; and to investigate genetic and environmental contributions to associations between sleep characteristics, chronotype and substance use in twins. The combination of careful assessment of subjective and objective sleep and chronotype, detailed evaluation of substance use patterns and sensitive clinical measures will provide a unique resource for the scientific community, and help guide age-appropriate behavioral interventions.

 描述（由适用提供）：青少年是与物质使用率急剧增加有关的关键神经发育期。确定使用物质使用的途径及其对儿童和青少年发育的影响至关重要，因为持续成熟过程中物质使用的影响可能对脑功能，行为，健康，心理结局具有长期影响。 SRI International的这一研究项目现场应用是对RFA-DA-15-015的响应，作为ABCD-USA财团的一部分（10/13），以预期确定对儿童和青少年物质使用的神经发育和行为预测因素以及使用物质的后果。将招募550个9-10岁的代表性社区样本，以富含高风险特征，从而从ABCD-USA联盟中的11个枢纽收集11,111个样本。所有参与者将接受全面的基线评估，包括最新的脑成像，全面的神经心理学测试，生物测定，移动监测和仔细评估药物使用，环境，精神病理学症状以及每2年的社交功能。临时年度访谈和季度基于Web的评估将以最少的参与伯恩（Burnen）提供精致的行为，发展和生活事件的临时解决。在本项目过程中获得的这些联盟范围内的数据将阐明：1）物质使用模式对青少年大脑的影响； 2物质使用对行为和健康结果的影响； 3）精神病理学与物质使用模式之间的双向关系； 4）个体遗传，行为，神经生物学和环境差异对风险特征和物质使用结果的影响； 5）使用不同物质之间的“网关相互作用”。我们的项目着重于整个财团收集的睡眠和时间生物学数据，包括问卷调查和带有可穿戴手腕追踪器的定期评估。我们的目的是评估睡眠行为和表型，作为随后使用物质使用的预测指标，并研究当前物质使用对青少年睡眠特征的影响。我们还将进行探索性分析，以确定使用大麻对睡眠的影响，以评估睡眠与时间生物学变量之间的关系，抑郁症的使用和发展；并研究双胞胎中睡眠特征，表型和物质使用之间关联的遗传和环境贡献。仔细评估主观和客观睡眠和表型的结合，对物质使用模式的详细评估以及敏感的临床措施将为科学界提供独特的资源，并有助于指导适合年龄的行为干预措施。