Emotion Regulation and Sleep in Alcohol Use Disorder

酒精使用障碍中的情绪调节和睡眠

• 批准号: 10254381
• 负责人: Fiona C Baker
• 金额: $ 27.38万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-05 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10254381
• 关键词: Abstinence; Adrenergic Agents; Affect; Affective; Age; Amygdaloid structure; Architecture; Attention; Brain; Chronic; Data; Disease; Emotional; Emotions; Equilibrium; Experimental Designs; Eye Movements; Female; Fracture; Functional Magnetic Resonance Imaging; Gender; Homeostasis; Impairment; Individual; Knowledge; Lead; Link; Literature; Magnetic Resonance Imaging; Measures; Mission; Modeling; National Institute on Alcohol Abuse and Alcoholism; Neural Pathways; Neurobiology; Pathway interactions; Patients; Pharmacotherapy; Polysomnography; Prefrontal Cortex; Process; Protocols documentation; REM Sleep; Recovery; Regulation; Relapse; Research; Research Personnel; Role; Sleep; Sleep disturbances; Slow-Wave Sleep; Structure; System; United States; Woman; alcohol craving; alcohol use disorder; behavior measurement; cholinergic; chronic alcohol ingestion; craving; design; disorder control; disorder later incidence prevention; emotion regulation; emotional functioning; emotional stimulus; functional MRI scan; health related quality of life; imaging modality; improved; indexing; male; men; multidisciplinary; neuroimaging; novel; poor sleep; pressure; prevent; rapid eye movement; relapse prediction; relating to nervous system; sex; sleep physiology; sleep quality; sleep regulation; success; tool development

PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) is a multifaceted, chronic relapsing disorder suffered by millions of men and women in the United States. AUD is associated with disrupted sleep continuity and architecture, including an abnormally high level of rapid eye movement (REM) sleep that persists long into abstinence, and which is a significant predictor of relapse. Emotion deficits, including affective flattening and mesocorticolimbic hypo-responsiveness to emotional stimuli, are consistent findings in AUD and also predict relapse. Here, we bring these two components together, building on an emerging literature showing that REM sleep is important for neural emotion regulation, calibrating emotions to promote next-day adaptive emotional functioning. We propose that the REM sleep-emotion pathway is dysfunctional in AUD, contributing to the deficits in emotion regulation in AUD shown by us and others, which lead to increased craving and relapse. Here, multidisciplinary researchers (Baker, Műller-Oehring) with combined expertise in AUD, sleep, fMRI, and emotion, aim to investigate the role of REM sleep in next-day emotional functioning in AUD. A novel counterbalanced, mixed-measures experimental design is applied in abstinent male and female AUD patients compared to age- and gender-matched healthy controls, all undergoing two experimental night conditions: uninterrupted sleep and selective REM sleep reduction, each followed by functional neuroimaging with emotion reactivity and emotion regulation tasks the following morning. We aim to (1) Determine relationships between REM sleep qualities (duration and intensity) and next-day neural emotional reactivity in AUD; (2) Determine specific effects of experimental REM sleep reduction on next-day neural emotional reactivity in AUD compared to healthy controls and compared to an uninterrupted sleep condition. We will also explore to what extent the sleep-emotion regulation link is adjustable with a REM sleep reduction protocol towards a more functionally-intact system that contributes to normalization of behavioral measures of emotion functioning and less alcohol craving in AUD. These studies open up new avenues into a mechanistic understanding of links between sleep processes and emotional brain function in AUD. Findings will inform a R01 application aimed at investigating the effects of sleep manipulation as a pathway to reset neural emotion regulation circuits, fracture the cycle of relapse, and improve management of AUD.

项目总结/摘要 酒精使用障碍（AUD）是一种多方面的慢性复发性疾病，数百万男性和女性遭受 在美国AUD与睡眠连续性和结构中断有关，包括异常的 高水平的快速眼动（REM）睡眠，持续到禁欲，这是一个重要的 复发的预测因子情感缺陷，包括情感扁平化和中皮质边缘反应低下 情绪刺激，是一致的发现，在AUD，也预测复发。我们把这两个 一项新兴的文献表明，快速眼动睡眠对神经情绪很重要， 调节，校准情绪，以促进第二天的适应性情绪功能。 我们认为，REM睡眠-情绪通路在AUD中功能失调，导致情绪缺陷 我们和其他人所显示的AUD调节，这导致了渴望和复发的增加。 在这里，多学科的研究人员（贝克，穆勒-Oehring）在AUD，睡眠，功能磁共振成像， 情绪，旨在探讨快速眼动睡眠在第二天情绪功能的AUD。一种新型 在禁欲的男性和女性AUD患者中应用平衡的混合测量实验设计 与年龄和性别匹配的健康对照相比，所有人都经历了两种实验性夜间条件： 不间断的睡眠和选择性的REM睡眠减少，每一个都随后进行功能性神经成像与情绪 第二天早上的反应和情绪调节任务。 我们的目标是（1）确定REM睡眠质量（持续时间和强度）与第二天神经功能之间的关系。 AUD的情绪反应;（2）确定实验性REM睡眠减少对第二天的具体影响 与健康对照组和不间断睡眠相比，AUD的神经情绪反应性 条件我们还将探讨在何种程度上睡眠-情绪调节环节是可调节的快速眼动睡眠 减少协议朝着一个功能更完整的系统，有助于正常化的行为 情绪功能和较少的酒精渴望的措施。 这些研究开辟了新的途径，以机械的理解睡眠过程之间的联系， 情绪脑功能在AUD研究结果将为旨在调查睡眠影响的R 01应用程序提供信息 操纵作为重置神经情绪调节回路的途径，打破复发的循环，并改善 管理AUD。