Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescents

项目摘要 青少年时期的社会重新定位伴随着广泛的神经发育变化。 为了了解神经发育网络对社会环境的反应以及社会如何 联系影响神经发育，需要操纵青少年的社会联系， 这在大规模环境中是不可能的。2020年，新冠疫情爆发， 对青少年大脑认知发展（ABCD）研究的参与者进行纵向随访， 在这项研究中，青少年的社会联系发生了巨大的变化。因为待在家里的水平 由于对参与者的流行前状态不可知地施加了限制， 在青少年中进行社会联系的实验。加上全面的大流行前 评估、对大流行期间收集的调查和地理位置数据进行纵向跟踪， 以及恢复多模式成像扫描和定期评估， 在2021年之后，我们可以使用纵向ABCD数据来批判性地研究社会 联系和神经发育。特别是，我们建议使用ABCD数据， 调查1）使个体对以下疾病更敏感的神经生物学和社会因素（大流行前） 社会联系的中断（大流行期），导致期间及以后的情绪动荡 大流行期间; 2）缓冲/加剧情绪反应的调节因素， 长期的社会破坏（大流行期）;和3）神经发育的偏差程度后， 大流行（大流行后）与ABCD参与者不同程度的社会破坏有关， 大流行病我们将通过利用一种新的组合方法从高维 数据分析和总体推断，创新性地定制分析策略，以避免潜在的偏见 和虚假的联系拟议的研究具有很高的公共卫生利益，因为确定了 神经生物学机制潜在的情绪反应对社会的破坏 连通性将为青少年的治疗和公共卫生干预提供新的见解， 到人口知情的ABCD样本。通过分享我们开发的工具和衍生的社会变量， 研究计划，我们将立即影响该领域。这些新的分析工具使我们和其他人能够 更深入地研究ABCD数据，特别是与社会相关的神经发育过程， 连通性结果可以为大流行期间和大流行后的临床实践提供信息，以恢复和改善心理健康。 青春健康。

PROJECT SUMMARY The social reorientation of the adolescent period is accompanied by extensive neurodevelopmental changes. To understand the neurodevelopmental networks underlying responses to social environments and how social connectedness influences neurodevelopment, manipulation of social connectedness among youth is required, which is impossible in a large-scale setting. In 2020, the COVID pandemic happened, in the midst of longitudinal follow-up of participants in the Adolescent Brain Cognition Development (ABCD) study, inducing dramatic changes to social connectedness in adolescents in the study. Because the levels of stay-at-home restriction were imposed agnostically to participants' pre-pandemic status, this becomes a naturally occurred experiment on social connectedness among adolescents. Together with the comprehensive pre-pandemic assessments, longitudinal follow-up with surveys and geolocation data collected during the pandemic period, and the resumption of multimodal imaging scans and regular assessments restarting during, and continuing after 2021, we can use longitudinal ABCD data to critically examine the relationships between social connectedness and neurodevelopment among youth. In particular, we propose to use ABCD data to investigate 1) the neurobiological and social factors (pre-pandemic) that render an individual more sensitive to the disruption of social connectedness (peri-pandemic), contributing to emotional turmoil during and beyond the pandemic period; 2) the modulating factors that buffer/exacerbate the emotion responses during a prolonged period of social disruption (peri-pandemic); and 3) the extent of deviation in neurodevelopment after the pandemic (post-pandemic) in relation to the varying levels of social disruptions in ABCD participants during the pandemic. We will pursue these aims by utilizing a novel combination of methods from high-dimensional data analysis and population inference, innovatively tailoring the analytic strategies to avoid potential biases and spurious associations. The proposed research is of high public health interest because the identified neurobiological mechanisms underlying the emotional responses toward the disruption of social connectedness will provide novel insights for therapeutics and public health interventions in adolescents, due to the population-informed ABCD sample. By sharing our developed tools and derived social variables for this research program, we will impact the field immediately. These novel analytic tools enable us and others to more deeply investigate with ABCD data, neurodevelopmental processes specifically related to social connectedness. Results can inform peri- and post-pandemic clinical practice to regain and improve mental health in youth.