Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescents

与流行病相关的社会联系中断对青少年大脑和情绪健康的影响

• 批准号: 10681759
• 负责人: Fiona C Baker
• 金额: $ 85.26万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681759
• 关键词: 14 year old; Adaptive Behaviors; Address; Adolescence; Adolescent; Affective; Behavior assessment; Behavioral; Biosocial; Brain; Brain imaging; Buffers; COVID-19 pandemic; Cognition; Cognitive; Complex; Data; Data Analyses; Data Set; Development; Diffusion Magnetic Resonance Imaging; Emotional; Emotions; Ensure; Equilibrium; Functional Magnetic Resonance Imaging; Genetic; Genetic Predisposition to Disease; Goals; Home; Human; Image; Individual; Loneliness; Long-Term Effects; Longitudinal cohort; Magnetic Resonance Imaging; Measures; Mediating; Mental Depression; Mental Health; Methods; Moods; Multimodal Imaging; Neurobiology; Neurotic Disorders; Outcome; Participant; Personal Satisfaction; Phenotype; Play; Population; Process; Public Health; Research; Resources; Rest; Role; Sampling; Scanning; Scoring Method; Shapes; Site; Social Behavior; Social Conditions; Social Environment; Social Interaction; Social Protection; Social support; Structure; Subgroup; Surveys; System; Therapeutic; Well in self; Work; Youth; advanced analytics; analytical tool; clinical practice; cognitive development; experience; experimental study; family support; follow up assessment; follow-up; improved; information processing; innovation; insight; interest; longitudinal analysis; mentalization; multidimensional data; multimodality; neural; neural network; neurobiological mechanism; neurodevelopment; novel; pandemic disease; pandemic impact; peer; post-pandemic; pre-pandemic; programs; prospective; psychosocial; public health intervention; response; sex; sleep quality; social; social culture; social factors; social relationships; tool

PROJECT SUMMARY The social reorientation of the adolescent period is accompanied by extensive neurodevelopmental changes. To understand the neurodevelopmental networks underlying responses to social environments and how social connectedness influences neurodevelopment, manipulation of social connectedness among youth is required, which is impossible in a large-scale setting. In 2020, the COVID pandemic happened, in the midst of longitudinal follow-up of participants in the Adolescent Brain Cognition Development (ABCD) study, inducing dramatic changes to social connectedness in adolescents in the study. Because the levels of stay-at-home restriction were imposed agnostically to participants' pre-pandemic status, this becomes a naturally occurred experiment on social connectedness among adolescents. Together with the comprehensive pre-pandemic assessments, longitudinal follow-up with surveys and geolocation data collected during the pandemic period, and the resumption of multimodal imaging scans and regular assessments restarting during, and continuing after 2021, we can use longitudinal ABCD data to critically examine the relationships between social connectedness and neurodevelopment among youth. In particular, we propose to use ABCD data to investigate 1) the neurobiological and social factors (pre-pandemic) that render an individual more sensitive to the disruption of social connectedness (peri-pandemic), contributing to emotional turmoil during and beyond the pandemic period; 2) the modulating factors that buffer/exacerbate the emotion responses during a prolonged period of social disruption (peri-pandemic); and 3) the extent of deviation in neurodevelopment after the pandemic (post-pandemic) in relation to the varying levels of social disruptions in ABCD participants during the pandemic. We will pursue these aims by utilizing a novel combination of methods from high-dimensional data analysis and population inference, innovatively tailoring the analytic strategies to avoid potential biases and spurious associations. The proposed research is of high public health interest because the identified neurobiological mechanisms underlying the emotional responses toward the disruption of social connectedness will provide novel insights for therapeutics and public health interventions in adolescents, due to the population-informed ABCD sample. By sharing our developed tools and derived social variables for this research program, we will impact the field immediately. These novel analytic tools enable us and others to more deeply investigate with ABCD data, neurodevelopmental processes specifically related to social connectedness. Results can inform peri- and post-pandemic clinical practice to regain and improve mental health in youth.

项目概要 青春期的社会重新定位伴随着广泛的神经发育变化。 了解对社会环境反应的神经发育网络以及社会如何 连通性影响神经发育，需要操纵青少年之间的社会连通性， 这在大规模环境中是不可能的。 2020年，新冠肺炎疫情爆发， 对青少年大脑认知发展（ABCD）研究参与者进行纵向随访，诱导 研究中青少年的社会联系发生了巨大变化。因为待在家里的水平 对参与者大流行前的状态施加了不可知的限制，这成为自然发生的事情 青少年之间的社会联系实验。结合疫情前的综合防控 评估、对大流行期间收集的调查和地理定位数据进行纵向跟踪， 并在持续期间重新开始多模态成像扫描和定期评估 2021年后，我们可以使用纵向ABCD数据来批判性地审视社会之间的关系 青少年之间的联系和神经发育。特别是，我们建议使用 ABCD 数据 调查 1) 使个体对以下因素更加敏感的神经生物学和社会因素（大流行前） 社会联系的破坏（大流行期间），导致大流行期间和之后的情绪动荡 疫情期间； 2）缓冲/加剧情绪反应的调节因素 长期的社会混乱（大流行期间）； 3）神经发育的偏差程度 流行病（流行病后）与 ABCD 参与者不同程度的社会混乱有关 大流行。我们将通过利用高维方法的新颖组合来实现这些目标 数据分析和总体推断，创新地定制分析策略以避免潜在的偏差 和虚假的联想。拟议的研究具有很高的公共卫生利益，因为已确定 对社交破坏的情绪反应背后的神经生物学机制 连通性将为青少年的治疗和公共卫生干预提供新的见解，因为 到总体知情的 ABCD 样本。通过分享我们为此开发的工具和派生的社会变量 研究计划，我们将立即影响该领域。这些新颖的分析工具使我们和其他人能够 使用 ABCD 数据更深入地研究与社交相关的神经发育过程 连通性。结果可以为大流行期间和之后的临床实践提供信息，以恢复和改善精神状态 青春健康。