CSHL 2016 Axon Guidance,Synapse Formation and Regeneration Conference

描述（由申请人提供）：拟于2016年9月20日至24日在冷泉港实验室举行的关于“轴突指导，突触形成和再生”的会议将聚集该领域的领导者，初级教师，博士后研究员和研究生，讨论会议标题中定义的领域的新的前沿发展。该提案寻求对在冷泉港实验室举行的两年期系列会议的第十次会议的支持，该会议已成为世界上这一领域的首次会议。2016年会议将讨论的议题包括：引导信号及其受体的识别和表征; ii.将受体的激活转化为运动性变化的信号转导机制的解剖; iii.识别和表征调节突触形成和突触特异性的信号; IV.识别神经元活动塑造突触连接模式的信号传导机制; V.神经元极性和树突模式的机制; VI.调节神经回路和行为发展的机制之间的关系; vii.识别退化和再生的信号机制;和viii.机制与疾病的关系。不同的实验方法（包括细胞生物学，生物化学，遗传学和电生理学）和系统（包括各种脊椎动物和无脊椎动物模型系统，用于研究神经连接和功能）将被强调。鉴于目前在这一领域采用的各种方法，国际研究人员之间的交流对于促进研究和理解调节神经系统布线的基本机制以及这些机制如何与神经系统疾病的原因和潜在治疗方法相关至关重要。口头发言将由会议主席与组织者协商选定。每次会议将由该领域的两位顶尖科学家主持。选定的演讲者主要包括研究生，博士后研究员和初级教师。三个特别讲座将提供必要的背景至关重要，以刺激科学家之间的讨论工作相关，但不同的领域。还将有三个海报会议，大多数与会者可以介绍他们的工作。会议规模适中，预计将有250-350名神经科学家出席。

DESCRIPTION (provided by applicant):The proposed meeting to be held at Cold Spring Harbor Laboratory on "Axon Guidance, Synapse Formation, and Regeneration" on September 20 - 24, 2016 will assemble leaders in the field, junior faculty, postdoctoral fellows and graduate students to discuss new, cutting-edge developments in the areas defined in the meeting title. This proposal seeks support for the tenth of a biennial series of meetings held at Cold Spring Harbor Laboratory that has emerged as the premiere meeting in the world for this field. Topics to be discussed for the 2016 meeting will include: i. the identification and characterization of guidance signals and their receptors; ii. The dissection of the signal transduction machinery that translates activation of receptors into changes in motility; iii. The identification and characterization of signals that regulate synapse formation and synaptic specificity; IV. The identification of the signaling mechanisms by which neuronal activity sculpts patterns of synaptic connectivity; v. mechanisms of neuronal polarity and dendritic patterning; VI. The relationship between mechanisms that mediate development of neural circuits and behavior; vii. The identification of the signaling mechanisms underlying degeneration and regeneration; and viii. The relationship between mechanisms and disease. Diverse experimental approaches (including cell biology, biochemistry, genetics, and electrophysiology) and systems (including various vertebrate and invertebrate model systems for investigating neural connectivity and function) will be highlighted. Given the diverse approaches currently employed in this field, communication among international researchers is essential to advance research and understanding of fundamental mechanisms that regulate wiring of the nervous system and how these mechanisms may relate to the causes and potential cures for neurological disease. Oral presentations will be selected by the session chairs in consultation with the organizers. Each session will be chaired by two leading scientists in the field. Selected speakers primarily include graduate students, postdoctoral fellows and junior faculty. Three special lectures will be presented to provide essential background critical to stimulating discussion between scientists working on related but distinct areas. There will also be three poster sessions where a majority of participants can present their work. The meeting will be of moderate size, and we expect 250-350 neuroscientists in attendance.