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Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms

Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
新型鞘脂生物学和疾病机制的小鼠模型
批准号：
9356146
负责人：
Richard Proia
金额：
$56.08万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9356146
关键词：
AdultAnimal ModelBiologicalBiological ProcessBiologyDevelopmentDiseaseEnzymesGoalsHomeostasisInvestigationLipidsMalignant NeoplasmsMetabolicMetabolic DiseasesMetabolic PathwayMetabolismMusPathway interactionsPhysiologicalPhysiological ProcessesSignal TransductionSignaling MoleculeSphingolipidshuman diseasemouse modelnovelreceptor

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中文摘要
翻译
鞘脂代谢途径产生高度活性的脂质信号分子，其调节发育期间的许多生理过程和成人的体内平衡。 此外，该途径受到高度调节，并且在某些紊乱状态下（例如在癌症和代谢疾病中）似乎功能异常。 我们正在利用在鞘脂代谢和信号传导方面进行修饰的转基因小鼠，以揭示鞘脂在正常生物学和疾病中的新功能。
英文摘要
The sphingolipid metabolic pathway yields highly active lipid signaling molecules that regulate many physiologic processes during development and for homeostasis in the adult. Furthermore, the pathway is highly regulated and appears to function abnormally in certain disordered states such as in cancer and in metabolic diseases. We are utilizing genetically altered mice that are modified in their sphingolipid metabolism and signaling to uncover new functions of sphingolipids in normal biology and in disease.
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会议论文
Sphingolipid Biology of Inflammation and Immunity
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
Sphingolipid Biology of Neurodegeneration
Sphingolipid Biology and Regulation of Metabolism
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