Sphingolipid Biology of Cancer

鞘脂类癌症生物学

• 批准号: 8939636
• 负责人: Richard Proia
• 金额: $ 59.55万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8939636
• 关键词: Apoptosis; Cancer Biology; Cell Death; Development; Family; G-Protein-Coupled Receptors; Goals; Growth and Development function; Inflammation; Life; Lipids; Malignant Neoplasms; Metabolism; Mus; Neoplasm Metastasis; Process; Receptor Signaling; Reporter; Signal Pathway; Signal Transduction; Signaling Molecule; Sphingolipids; angiogenesis; inorganic phosphate; lipid mediator; novel; response; tumor; tumorigenesis

Shpingosine-1-phosphate (S1P) is a bioactive lipid mediator that interacts with a a family of G-protein coupled receptors. S1P signaling regulates several of the hallmarks of cancer including the induction of angiogenesis, resisting cell death, sustaining proliferative signaling, tumor-promoting inflammation and activating invasion and metastasis. Furthermore, S1P metabolism has been found to be disturbed in several types of tumors providing further support for a linkage between pleiotropic actions of S1P to oncogenesis. We are using novel S1P signaling reporter mice to identify S1P receptor signaling in live mice in response to tumor development, growth and metastasis.

Shpingosine-1-磷酸 (S1P) 是一种生物活性脂质介质，可与 G 蛋白偶联受体家族相互作用。 S1P信号传导调节癌症的几个特征，包括诱导血管生成、抵抗细胞死亡、维持增殖信号传导、促进肿瘤的炎症以及激活侵袭和转移。 此外，已发现 S1P 代谢在多种类型的肿瘤中受到干扰，这为 S1P 的多效作用与肿瘤发生之间的联系提供了进一步的支持。 我们正在使用新型 S1P 信号报告小鼠来识别活体小鼠中响应肿瘤发展、生长和转移的 S1P 受体信号。