课题基金 / 基金详情

Sphingolipid Biology of Cancer

Sphingolipid Biology of Cancer
鞘脂类癌症生物学
批准号：
8939636
负责人：
Richard Proia
金额：
$59.55万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8939636
关键词：
ApoptosisCancer BiologyCell DeathDevelopmentFamilyG-Protein-Coupled ReceptorsGoalsGrowth and Development functionInflammationLifeLipidsMalignant NeoplasmsMetabolismMusNeoplasm MetastasisProcessReceptor SignalingReporterSignal PathwaySignal TransductionSignaling MoleculeSphingolipidsangiogenesisinorganic phosphatelipid mediatornovelresponsetumortumorigenesis

项目摘要

项目成果

Richard Proia的其他基金

相似基金

相关文献

中文摘要
翻译
什平腺苷-1-磷酸（S1 P）是一种生物活性脂质介质，与一个G蛋白偶联受体家族相互作用。S1 P信号传导调节癌症的几个标志，包括诱导血管生成、抵抗细胞死亡、维持增殖信号传导、肿瘤促进炎症以及激活侵袭和转移。 此外，已发现S1 P代谢在几种类型的肿瘤中受到干扰，进一步支持S1 P的多效性作用与肿瘤发生之间的联系。 我们正在使用新型S1 P信号转导报告小鼠来鉴定活体小鼠中响应肿瘤发展、生长和转移的S1 P受体信号转导。
英文摘要
Shpingosine-1-phosphate (S1P) is a bioactive lipid mediator that interacts with a a family of G-protein coupled receptors. S1P signaling regulates several of the hallmarks of cancer including the induction of angiogenesis, resisting cell death, sustaining proliferative signaling, tumor-promoting inflammation and activating invasion and metastasis. Furthermore, S1P metabolism has been found to be disturbed in several types of tumors providing further support for a linkage between pleiotropic actions of S1P to oncogenesis. We are using novel S1P signaling reporter mice to identify S1P receptor signaling in live mice in response to tumor development, growth and metastasis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Sphingolipid Biology of Neurodegeneration
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
Sphingolipid Biology of Inflammation and Immunity
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
海外基金