课题基金 / 基金详情

Sphingolipid Biology of Inflammation and Immunity

Sphingolipid Biology of Inflammation and Immunity
炎症和免疫的鞘脂生物学
批准号：
8148855
负责人：
Richard Proia
金额：
$34.56万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8148855
关键词：
BiologyImmunityInflammationSphingolipids

项目摘要

项目成果

Richard Proia的其他基金

相似基金

相关文献

中文摘要
翻译
我们正在研究鞘磷脂调节免疫和炎症的机制。我们的重点是鞘氨醇-1-磷酸(S1P)，一种富含在血管和淋巴系统的生物活性脂质，以及免疫细胞和内皮上发现的S1P受体。已发现S1P及其受体在免疫系统发育和体内平衡以及调节免疫反应和炎症方面发挥重要作用。我们正在研究S1P受体和鞘磷脂代谢途径在炎症和免疫中的单独作用。
英文摘要
We are studying the mechanism by which sphingolipids regulate immunity and inflammation. Our focus has been on sphingosine-1-phosphate (S1P), a bioactive lipid enriched in the vascular and lymphatic systems, and the S1P receptors, found on immune cells and the endothelium. Essential roles for S1P and its receptors have been found for immune system development and homeostasis as well as for the regulation of immune responses and inflammation. We are studying the individual roles of the S1P receptors and the sphingolipid metabolic pathway in inflammation and immunity.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Sphingolipid Biology of Neurodegeneration
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
Sphingolipid Biology of Inflammation and Immunity
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
海外基金