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Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms

Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
新型鞘脂生物学和疾病机制的小鼠模型
批准号：
10255240
负责人：
Richard Proia
金额：
$80.57万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10255240
关键词：
AdultAnimal ModelBiologicalBiological ProcessBiologyDevelopmentDiseaseEnzymesGoalsHomeostasisInvestigationLipidsMalignant NeoplasmsMetabolicMetabolic DiseasesMetabolic PathwayMetabolismMusPathway interactionsPhysiologicalPhysiological ProcessesSignal TransductionSignaling MoleculeSphingolipidsStructurehuman diseasemouse modelnovelreceptor

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中文摘要
翻译
鞘磷脂代谢途径产生高度活跃的脂质信号分子，在发育过程中调节许多生理过程，并促进成年动物的动态平衡。此外，该途径受到高度调控，在某些无序状态下似乎功能异常，如癌症和代谢性疾病。我们正在利用基因改变的小鼠，这些小鼠在鞘脂代谢和信号方面进行了修改，以揭示鞘脂在正常生物学和疾病中的新功能。
英文摘要
The sphingolipid metabolic pathway yields highly active lipid signaling molecules that regulate many physiologic processes during development and for homeostasis in the adult. Furthermore, the pathway is highly regulated and appears to function abnormally in certain disordered states such as in cancer and in metabolic diseases. We are utilizing genetically altered mice that are modified in their sphingolipid metabolism and signaling to uncover new functions of sphingolipids in normal biology and in disease.
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会议论文
Sphingolipid Biology of Neurodegeneration
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
Sphingolipid Biology of Inflammation and Immunity
Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms
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