Institute for Biogenesis Research: COBRE

描述（由申请人提供）：COBRE第一阶段的支持使生物发生研究所（IBR）成为公认的生殖生物学研究卓越中心。IBR支持教师对人类生殖各个方面的研究以及与生殖生物学相关的问题。IBR的成功在很大程度上是由于我们教师的科学专业知识和研究兴趣的凝聚力，结合我们在生殖生物学方面的专业知识。我们越来越多的国际认可是由客座教授，我们的初级研究人员的选择NIH面板，出版物的一长串，并已获得赠款以及授予的评估证明。在COBRE支持的前四年中获得支持的五名初级研究人员中有四名已经发展了他们的研究，他们可以作为项目负责人的导师或合作者，这些项目负责人将在拟议的IBR COBRE第二阶段中获得支持。 在这项申请中，我们寻求加强和改造IBR成为一个多学科的生殖生物学研究中心，将成为独立的，足以维持其未来发展的校外赠款支持。在未来五年的第二阶段COBRE资助期间，我们将专注于扩大我们的研究重点和专业知识，而第一阶段IBR项目领导人将成为该研究所更成熟的成员。第一阶段的中心教师拥有一套有凝聚力的实验和科学专业知识，专注于受精和早期发育，包括广泛的显微操作和细胞生物学技术。在第二阶段，我们将大大扩展我们的科学和技术专长，包括下一代测序（NGS）和NGS数据的生物信息学分析。我们认为这是我们中心的一次重要扩展，我们已经证明了在获取NGS数据并将其纳入当前研究项目方面的熟练程度。我们新招募的项目负责人中有三位熟悉获取NGS数据，第四位是具有分析大型基因组数据库经验的生物信息学家。我们寻求将该中心发展成为一个更强大，自我支持的研究所，拥有广泛的科学专长，可以更有效地竞争中心赠款资金。我们建议通过以下具体目标来实现这些目标：（SA1）通过指导四名新的研究人员来扩大IBR的多学科研究能力。(SA2)通过IBR教师的持续发展加强中心，并为中心招聘高级研究员。(SA3)通过扩大转基因小鼠、ICSI和IVF（TMII）核心，加强IBR和机构的研究基础设施。

DESCRIPTION (provided by applicant): The COBRE Phase I support has allowed the Institute for Biogenesis Research (IBR) to emerge as a recognized center of excellence in the study of reproductive biology. The IBR supports faculty research on various aspects of human reproduction and problems related to reproductive biology. The IBR's success is in large part due to the scientific expertise of our faculty and the cohesion of the research interests, in conjunction with our expertise in reproductive biology. Our growing international recognition is evidenced by assessments given by visiting professors, the selection of our junior investigators to NIH panels, a long list of publications, and that have been grants scored as well as awarded. Four of the five junior investigators who were supported in the first four years of COBRE support have developed their research to the point that they can serve as mentors or collaborators for the Project Leaders who will be supported in the proposed Phase II IBR COBRE. In this application, we seek to strengthen and transform the IBR into a multi-disciplinary reproductive biology research center that will become independent enough to be sustained on extramural grant support for its future development. We will focus on expanding our research focus and expertise during the next five years of Phase II COBRE funding, while the Phase I IBR Project Leaders become more mature members of the institute. The Center faculty in Phase I had a cohesive set of experimental and scientific expertise that focused on fertilization and early development and included a wide range of micromanipulation and cell biology techniques. In Phase II, we will significantly expand our scientific and technical expertise to include next generation sequencing (NGS) and bioinformatic analysis of NGS data. We feel that this is an important expansion for our Center, and we have already demonstrated a proficiency in obtaining NGS data and incorporating it into current research projects. Three of our newly recruited Project Leaders are familiar with obtaining NGS data, and the fourth is a bioinformaticist who has experience in analyzing large genomic databases. We seek to develop the Center into a more robust, self-supporting institute with a wide breadth of scientific expertis that can more effectively compete for center grant funding. We propose to accomplish these goals through the following Specific Aims: (SA1) Expand the multi-disciplinary research capacity of the IBR through the mentoring of four new investigators. (SA2) Strengthen the center through continued development of IBR faculty, and the recruitment of a senior investigator to the center. (SA3) Enhance the research infrastructure of both the IBR and the institution through the expansion of the Transgenic Mouse, ICSI and IVF (TMII) Core.