Microglia in the Brain

描述（由申请人提供）：要求支持由Beth Stevens和Richard M. Ransohoff组织的题为“大脑中的小胶质细胞”的Keystone专题会议。会议将于2016年6月12日至16日在科罗拉多州基斯顿举行。在过去的五年里，我们对小胶质细胞的起源和功能的理解取得了惊人的进展，就好像发现了一种全新的中枢神经系统（CNS）细胞类型。自从它们在100年前被发现以来，人们一直怀疑这些小胶质细胞与几乎所有的神经系统紊乱有关。小胶质细胞基因多态性变异的关联现在已经证明了这一假设。因此，迫切需要研究人员对患病中枢神经系统中小胶质细胞的起源、生理功能和异常特性的现状进行连贯的描述。这次会议将进一步实现将新信息转化为研究和治疗策略的目标。在许多方面，该领域的突出障碍

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Microglia in the Brain, organized by Beth Stevens and Richard M. Ransohoff. The meeting will be held in Keystone, Colorado from June 12-16, 2016. In the past five years, our understanding of the origins and functions of microglia, the unique myeloid cells of the central nervous system (CNS) parenchyma, has proceeded at such a remarkable pace that it's as if an entirely new CNS cell type had been discovered. Since their discovery 100 years ago, it has been suspected those microglias are implicated in virtually all disorders of the nervous system. Associations of polymorphic variants of microglial genes have now proven this hypothesis. It is therefore rather urgent to engage investigators in developing a coherent account of the present status of microglial origins, physiological functions and aberrant properties in the diseased CNS. This meeting will further the objective of translating new information into research and treatment strategies. In many ways, the salient barriers in the field can be addressed by sharing fundamental understanding of complex organ systems among investigators. Microglial research is now conducted in parallel among three disciplines: leukocyte biology, neuroscience and immunology. Other interested research groups include those studying neurodegeneration; developmental neurological disorders (autism, schizophrenia); aging; neuroimmune disorders; and stroke and brain trauma. Optimal progress can only be realized by bringing together thought leaders and students in these varied disciplines around the common goal of studying how microglia are involved in processes under investigation. The program will incorporate the extraordinary depth and breadth of scientists now examining microglial biology and will highlight cutting-edge imaging and genetic technologies. The concurrent meeting addressing Common Mechanisms of Neurodegeneration will enhance opportunities for interdisciplinary interactions.