Microglia in the Brain

大脑中的小胶质细胞

• 批准号: 9125542
• 负责人: DAVID L. WOODLAND
• 金额: $ 1.08万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2016-11-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9125542
• 关键词: Academia; Accounting; Address; Aging; Autistic Disorder; Behavior; Biological Models; Biology; Brain; Collaborations; Colorado; Complex; Data; Development; Discipline; Disease; Educational workshop; Fostering; Functional disorder; Genes; Goals; Health; Human; Imaging technology; Immunology; Industry; Investigation; Knowledge; Leukocytes; Mentors; Methodology; Microglia; Myeloid Cells; Nerve Degeneration; Neuraxis; Neurodegenerative Disorders; Neuroglia; Neuronal Plasticity; Neurons; Neurosciences; Outcome; Physiological; Population; Process; Property; Research; Research Personnel; Schizophrenia; Science; Scientist; Stroke; Students; Synapses; Translating; Traumatic Brain Injury; Variant; body system; cell type; clinical practice; design; genetic technology; human disease; interest; meetings; nervous system disorder; neurogenesis; neuropsychiatric disorder; new therapeutic target; novel; novel marker; posters; programs; prospective; symposium; tool; treatment strategy

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Microglia in the Brain, organized by Beth Stevens and Richard M. Ransohoff. The meeting will be held in Keystone, Colorado from June 12-16, 2016. In the past five years, our understanding of the origins and functions of microglia, the unique myeloid cells of the central nervous system (CNS) parenchyma, has proceeded at such a remarkable pace that it's as if an entirely new CNS cell type had been discovered. Since their discovery 100 years ago, it has been suspected those microglias are implicated in virtually all disorders of the nervous system. Associations of polymorphic variants of microglial genes have now proven this hypothesis. It is therefore rather urgent to engage investigators in developing a coherent account of the present status of microglial origins, physiological functions and aberrant properties in the diseased CNS. This meeting will further the objective of translating new information into research and treatment strategies. In many ways, the salient barriers in the field can be addressed by sharing fundamental understanding of complex organ systems among investigators. Microglial research is now conducted in parallel among three disciplines: leukocyte biology, neuroscience and immunology. Other interested research groups include those studying neurodegeneration; developmental neurological disorders (autism, schizophrenia); aging; neuroimmune disorders; and stroke and brain trauma. Optimal progress can only be realized by bringing together thought leaders and students in these varied disciplines around the common goal of studying how microglia are involved in processes under investigation. The program will incorporate the extraordinary depth and breadth of scientists now examining microglial biology and will highlight cutting-edge imaging and genetic technologies. The concurrent meeting addressing Common Mechanisms of Neurodegeneration will enhance opportunities for interdisciplinary interactions.

描述（由申请人提供）：支持的关键研讨会会议，题为脑中的小胶质细胞，由贝丝史蒂文斯和理查德M。兰索霍夫会议将于2016年6月12日至16日在科罗拉多的基斯通举行。在过去的五年里，我们对小胶质细胞（中枢神经系统（CNS）实质中独特的髓样细胞）的起源和功能的理解以如此惊人的速度进行，就好像发现了一种全新的CNS细胞类型。自100年前发现以来，人们一直怀疑这些小胶质细胞与几乎所有神经系统疾病有关。小胶质细胞基因多态性变体的关联现在已经证明了这一假设。因此，这是相当紧迫的，从事研究人员在发展一个连贯的帐户的现状，小胶质细胞的起源，生理功能和异常的性质在患病的中枢神经系统。这次会议将进一步实现将新信息转化为研究和治疗战略的目标。在许多方面，该领域的突出障碍 可以通过在研究者之间分享对复杂器官系统的基本理解来解决。小胶质细胞的研究现在平行于三个学科：白细胞生物学，神经科学和免疫学。其他感兴趣的研究小组包括研究神经变性、发育性神经障碍（自闭症、精神分裂症）、衰老、神经免疫障碍、中风和脑创伤的研究小组。只有将这些不同学科的思想领袖和学生聚集在一起，围绕研究小胶质细胞如何参与调查过程的共同目标，才能实现最佳进展。该计划将结合科学家现在研究小胶质细胞生物学的非凡深度和广度，并将突出尖端的成像和遗传技术。同时举行的会议解决神经退行性变的共同机制将增加跨学科互动的机会。