Heart Failure: Genetics, Genomics and Epigenetics

 描述（由申请人提供）：要求对由StuartA.作者：克莉丝汀E. Seidman和Yigal M.平托。会议将于2016年4月3日至7日在犹他州雪鸟举行。心力衰竭（HF）是一种世界性流行病，每年的治疗费用高达数百亿美元。尽管有这种投资，HF治疗在减少疾病进展方面的疗效有限。基础肌细胞生物学、HF病因学和致病机制的最新见解正在推动治疗和预防HF的新策略。本次会议将探讨生物和技术的进步，为遗传结构，分子发病机制和治疗HF的创新方法提供信息。这是在非常大的人类HF数据集可用并且可以使用先进的计算和生物信息学方法进行询问的时候。具体目标是：1）考虑人类收缩期和舒张期HF中涉及的基因，分子，信号通路和生物标志物; 2）探索模型系统中HF的潜在疾病机制; 3）了解表观遗传学，miRNA和lncRNA在HF发病机制中的作用; 4）审查基因组，药理学和基于细胞的治疗方法中的翻译程序以治疗HF。这次会议的成果应该是深远的基础，翻译和临床社区。会议还应为年轻科学家提供一个很好的培训计划，并促进研究、临床和工业参与者之间的合作。本次会议与心脏发育，再生和修复会议一起举行，为遗传学，iPSC疾病建模，干细胞治疗和表观遗传学的联合会议提供了绝佳的机会。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Heart Failure: Genetics, Genomics and Epigenetics, organized by Stuart A. Cook, Christine E. Seidman and Yigal M. Pinto. The meeting will be held in Snowbird, Utah from April 3-7, 2016. Heart failure (HF) is a worldwide epidemic with treatments costing tens of billions of dollars every year. Despite this investment, HF therapies have limited efficacy in reducing disease progression. Recent insights in fundamental myocyte biology, HF etiologies and pathogenic mechanisms are propelling new strategies to treat and prevent HF. This meeting will explore biologic and technical advances that inform the genetic architecture, molecular pathogenesis and innovative approaches to treat HF. This comes at a time when very large human HF datasets are available and can be interrogated using advanced computational and bioinformatic approaches. Specific aims are to: 1) Consider genes, molecules, signaling pathways and biomarkers involved in systolic and diastolic HF in humans; 2) Explore disease mechanisms underlying HF in model systems; 3) Understand the role of epigenetics, miRNAs and lncRNAs in HF pathogenesis; and 4) Review translational programs in genomic, pharmacologic and cell-based therapeutics to treat HF. The outcomes of this meeting should be far-reaching for basic, translational and clinical communities. The meeting should also provide an excellent training program for junior scientists and serve as a catalyst for collaboration among research, clinical and industrial participants. This meeting is being held in conjunction with the Cardiac Development, Regeneration and Repair meeting that provides an outstanding opportunity for joint sessions in genetics, iPSC disease modeling, stem cell therapeutics and epigenetics.