Nuclear Receptors: Full Throttle

核受体：全力以赴

• 批准号: 8985996
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.6万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8985996
• 关键词: Academia; Address; Adverse effects; Area; Binding; Biology; Cancer Etiology; Cardiovascular Diseases; Cessation of life; Cholestasis; Chromatin Structure; Clinical; Collaborations; Complex; Conflict (Psychology); Data; Development; Diabetes Mellitus; Dietary Fats; Discipline; Disease; Drug Targeting; Educational workshop; Emerging Technologies; Endocrine System Diseases; Family; Fatty acid glycerol esters; Fertilization; Future; Gene Expression Regulation; Genetic; Genetic Transcription; Genome; Health; Homeostasis; Hormones; Human; Hypertension; Immune system; Industry; Inflammation; Joints; Knowledge; Learning; Ligands; Longevity; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Membrane; Metabolic Diseases; Metabolism; Methodology; Modeling; Molecular; Nuclear; Nuclear Receptors; Obesity; Outcome; Pharmacologic Substance; Physiological; Physiology; Play; Process; Proteome; Quality of life; Regulator Genes; Reproduction; Research; Research Personnel; Role; Science; Scientist; Senior Scientist; Signal Pathway; Signal Transduction; Speed; Tissues; Translations; Utah; Vitamins; Woman; Work; advanced disease; career; clinical practice; combinatorial; drug development; immune function; improved; innovative technologies; insight; interest; malignant breast neoplasm; meetings; men; neoplastic; new technology; next generation; non-genomic; novel; novel strategies; posters; prevent; programs; public health relevance; receptor; receptor function; resistance mechanism; response; sensor; steroid hormone receptor; symposium; therapy resistant; transcription factor

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Nuclear Receptors: Full Throttle, organized by Carol A. Lange, Jennifer K. Richer and Karen E. Knudsen. The meeting will be held in Snowbird, Utah from January 10-15, 2016. Nuclear receptors (NRs) represent a large superfamily of ligand-dependent transcription factor "sensors" for a diverse set of fat-soluble hormones, vitamins and dietary lipids. NRs orchestrate genetic response programs critical for normal homeostasis, and are required for reproduction, development, metabolism and immune function. For this reason, NRs have been investigated for over 30 years as promising targets for drugs to treat a broad spectrum of diseases including cancer, diabetes and other endocrine or metabolic disorders, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. Research on NRs has led to numerous successful therapies for deadly diseases that have improved both longevity and quality of life. However, significant hurdles remain that involve further detailed understanding of the major gene regulatory networks regulated by NRs, how these differ in normal relative to pre-disease and disease states, and the complex problems associated with targeting tissue-specific effects (to reduce side effects) and circumventing mechanisms of resistance. Thus, further insight into the full range of NR functions and interactions with co-regulatory molecules and signaling pathways is necessary for combinatorial approaches involving NRs in health and disease, and development of next-generation therapies. This meeting will bring together a diverse array of our leading scientists, including senior and junior investigators and their trainees, from academic, clinical and pharmaceutical settings, to showcase the latest science, highlight the use of innovative and emerging technologies, explore new directions, and develop collaborative and synergistic efforts in the exciting field of NR biology.

 描述（由适用提供）：请求支持Keystone研讨会会议，标题为核受体：全油门，由Carol A. Lange，Jennifer K. Richer和Karen E. Knudsen组织。这次会议将于2016年1月10日至15日在犹他州的雪鸟举行。核受体（NRS）代表了一组依赖配体依赖的转录因子的超家族，用于一组潜水员的脂溶性恐怖剂，维生素和饮食脂质。 NRS编排对正常稳态至关重要的遗传反应计划，并且是繁殖，发展，代谢和免疫学功能所必需的。由于这个原因，已对NR进行了30多年的研究，作为治疗多种疾病的靶标，包括癌症，糖尿病和其他内分泌或代谢性疾病，肥胖，心血管疾病，高血压，高血压，注射，注射和胆汁疾病。 NRS的研究导致了许多致命疾病的成功疗法，这些疾病改善了寿命和生活质量。但是，仍然存在重大障碍，涉及对 由NRS调节的主要基因调节网络，它们相对于疾病前和疾病状态的正常状况以及与靶向组织特异性效应（减少副作用）和避免抗性机制相关的复杂问题。这是对涉及健康和疾病中NR的组合方法以及下一代疗法的发展，进一步了解NR功能的全部范围以及与共调节分子和信号通路的相互作用是必要的。这次会议将汇集一系列领先的科学家，包括学术，临床和制药环境，包括高级和初级研究人员及其学员，以展示最新的科学，强调使用创新和新兴技术，探索新的方向，并在NR生物学的令人兴奋的NR生物学领域中开发合作和协作和协作努力。