Noncoding RNAs in Health and Disease

非编码 RNA 在健康和疾病中的作用

• 批准号: 9039847
• 负责人: DAVID L. WOODLAND
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9039847
• 关键词: Address; Animal Model; Architecture; Area; Biochemical; Biochemistry; Biological; Biology; Chromatin; Clinic; Code; Collaborations; Complex; Conflict (Psychology); DNA; Development; Discipline; Disease; Dosage Compensation (Genetics); Drosophila genus; Emerging Technologies; Enhancers; Epigenetic Process; Eukaryota; Fostering; Future; Gene Expression Regulation; Genes; Genetic Models; Genetic Transcription; Genome; Genomics; Goals; Health; High-Throughput Nucleotide Sequencing; Knowledge; Lead; Longevity; Malignant Neoplasms; Methodology; Modeling; Molecular; Molecular Biology; Molecular Mechanisms of Action; Neurons; New Mexico; Nuclear; Outcome; Phenotype; Physiological; Plants; Proteins; RNA; RNA Sequences; Research; Research Personnel; Role; Schools; Scientist; Time; Transcript; Transcriptional Regulation; Translating; Translational Research; Untranslated RNA; Work; Yeasts; clinical practice; functional genomics; genome-wide; imprint; interest; meetings; new technology; novel; plant genetics; posters; public health relevance; symposium; yeast genetics

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Noncoding RNAs in Health and Disease, organized by Ramin Shiekhattar and Roberto Bonasio. The meeting will be held in Santa Fe, New Mexico from February 21-24, 2016. Over the past decade, there has been a greater understanding of genomic complexity in eukaryotes ushered in by the immense technological advances in high-throughput sequencing of DNA and its corresponding RNA transcripts. This has resulted in the realization that beyond protein-coding genes, there are a large number of transcripts that do not encode for proteins and, therefore, may perform their function through RNA sequences and/or through secondary and tertiary structural determinants. This meeting is focused on the latest findings concerning different classes of noncoding RNAs that use different strategies to regulate transcription. These are exciting times for discovering the biological scope and the mechanism of action for these RNA molecules, which have roles in dosage compensation, imprinting, enhancer function and transcriptional regulation, with a consequently great impact in development and disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Enhancer Malfunction in Cancer, which will share a keynote address and two plenary sessions with this meeting.