Noncoding RNAs in Health and Disease

 描述(申请人提供)：请求支持由Ramin Shiekhattar和Roberto Bonasio组织的题为《健康和疾病中的非编码RNA》的Keystone研讨会。会议将于2016年2月21日至24日在新墨西哥州圣达菲举行。在过去的十年里，随着DNA及其相应的RNA转录本的高通量测序技术的巨大进步，人们对真核生物的基因组复杂性有了更多的了解。这导致人们认识到，除了编码蛋白质的基因外，还有大量不编码蛋白质的转录本，因此可能通过RNA序列和/或通过二级和三级结构决定因素发挥其功能。这次会议的重点是关于不同类别的非编码RNA使用不同的策略来调节转录的最新发现。这些RNA分子在剂量补偿、印迹、增强子功能和转录调控等方面发挥作用，因此在发育和疾病中具有重大影响，因此这些RNA分子的生物学范围和作用机制令人兴奋。同时召开的癌症增强器功能障碍会议将显著增加跨学科互动的机会，该会议将与本次会议分享一次主旨演讲和两次全体会议。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Noncoding RNAs in Health and Disease, organized by Ramin Shiekhattar and Roberto Bonasio. The meeting will be held in Santa Fe, New Mexico from February 21-24, 2016. Over the past decade, there has been a greater understanding of genomic complexity in eukaryotes ushered in by the immense technological advances in high-throughput sequencing of DNA and its corresponding RNA transcripts. This has resulted in the realization that beyond protein-coding genes, there are a large number of transcripts that do not encode for proteins and, therefore, may perform their function through RNA sequences and/or through secondary and tertiary structural determinants. This meeting is focused on the latest findings concerning different classes of noncoding RNAs that use different strategies to regulate transcription. These are exciting times for discovering the biological scope and the mechanism of action for these RNA molecules, which have roles in dosage compensation, imprinting, enhancer function and transcriptional regulation, with a consequently great impact in development and disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Enhancer Malfunction in Cancer, which will share a keynote address and two plenary sessions with this meeting.