Noncoding RNAs in Health and Disease

 描述（由申请人提供）：要求支持由拉明Shiekhattar和Roberto Bonasio组织的题为健康和疾病中的非编码RNA的Keystone研讨会会议。会议将于2016年2月21日至24日在新墨西哥州圣达菲举行。在过去的十年中，由于DNA及其相应RNA转录物的高通量测序技术的巨大进步，人们对真核生物基因组的复杂性有了更深入的了解。这使得人们认识到，除了蛋白质编码基因之外，还有大量不编码蛋白质的转录物，因此，它们可能通过RNA序列和/或通过二级和三级结构决定簇来发挥功能。本次会议的重点是关于不同类别的非编码RNA的最新发现，使用不同的策略来调节转录。这些是发现这些RNA分子的生物学范围和作用机制的激动人心的时刻，这些RNA分子在剂量补偿、印记、增强子功能和转录调控中发挥作用，从而对发育和疾病产生重大影响。跨学科互动的机会将显着增强子在癌症中的功能障碍，这将与本次会议分享一个主题演讲和两个全体会议的同期会议增强。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Noncoding RNAs in Health and Disease, organized by Ramin Shiekhattar and Roberto Bonasio. The meeting will be held in Santa Fe, New Mexico from February 21-24, 2016. Over the past decade, there has been a greater understanding of genomic complexity in eukaryotes ushered in by the immense technological advances in high-throughput sequencing of DNA and its corresponding RNA transcripts. This has resulted in the realization that beyond protein-coding genes, there are a large number of transcripts that do not encode for proteins and, therefore, may perform their function through RNA sequences and/or through secondary and tertiary structural determinants. This meeting is focused on the latest findings concerning different classes of noncoding RNAs that use different strategies to regulate transcription. These are exciting times for discovering the biological scope and the mechanism of action for these RNA molecules, which have roles in dosage compensation, imprinting, enhancer function and transcriptional regulation, with a consequently great impact in development and disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Enhancer Malfunction in Cancer, which will share a keynote address and two plenary sessions with this meeting.