Stem Cells and Cancer

干细胞和癌症

• 批准号: 8985625
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2016-11-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8985625
• 关键词: Area; Biology; Cause of Death; Characteristics; Clinical Data; Clonal Evolution; Collaborations; Colorado; Critical Pathways; Development; Drug resistance; Elements; Epigenetic Process; Evolution; Fostering; Health; Heterogeneity; Human; Immune system; Investigation; Knowledge; Light; Maintenance; Malignant Neoplasms; Metabolic; Methodology; MicroRNAs; Mission; National Cancer Institute; Nature; Neoplasm Metastasis; Outcome; Pathway interactions; Pharmacologic Substance; Published Comment; Research; Research Personnel; Scientist; Shapes; Signal Transduction; Signal Transduction Pathway; Stem Cell Research; Stem cells; Students; Techniques; Therapeutic Intervention; United States; anticancer research; austin; cancer stem cell; clinical practice; combat; effective therapy; innovation; intercellular communication; interest; meetings; mortality; notch protein; novel therapeutics; posters; public health relevance; self-renewal; stem; stem cell biology; stem cell niche; symposium; targeted treatment; tumor; tumor heterogeneity

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Stem Cells and Cancer, organized by Austin Gurney, Connie J. Eaves and Jane E. Visvader. The meeting will be held in Breckenridge, Colorado from March 6-11, 2016. Cancer stem cells have now been recognized in a wide variety of human tumors. The existence of cancer stem cells poses both tremendous challenges and tantalizing potential for our ability to successfully combat cancer. This meeting aims to bring together scientists who are interested in better understanding the mechanisms by which cancer stem cells contribute to tumor heterogeneity, self-renewal and drug resistance. One area of emphasis will be intercellular communication. Cellular context and microenvironment establish the tumor niche and shape the interaction of the tumor with the immune system. In addition, developmental signal transduction pathways such as Hippo, Notch and Wnt, frequently deregulated in cancer, increasingly offer tangible opportunities for therapeutic intervention. Another important area of emphasis will be efforts to better understand the mechanisms and importance of tumor heterogeneity. Techniques such as clonal analysis and barcoding are shedding important light on the interplay between tumor evolution, differentiation, miRNA control and epigenetics. This is an era of rapid progress in understanding cancer stem cell biology with great potential to benefit human health, and it is a topic of clear relevance to the mission of the National Cancer Institute.

 描述(由申请者提供)：申请支持由奥斯汀·格尼、康妮·J·艾夫斯和简·E·维斯瓦德组织的题为干细胞与癌症的Keystone研讨会。会议将于2016年3月6日至11日在科罗拉多州布雷肯里奇举行。肿瘤干细胞现已在多种人类肿瘤中被识别。癌症干细胞的存在对我们成功抗击癌症的能力构成了巨大的挑战和诱人的潜力。这次会议的目的是让对更好地了解癌症干细胞促进肿瘤异质性、自我更新和耐药性的机制感兴趣的科学家们聚集在一起。其中一个重点领域将是细胞间通信。细胞环境和微环境建立了肿瘤的生态位，并塑造了肿瘤与免疫系统的相互作用。此外，发育中的信号转导通路，如河马、Notch和Wnt，在癌症中经常被解除调控，越来越多地为治疗干预提供了有形的机会。另一个重要的重点领域将是努力更好地了解肿瘤异质性的机制和重要性。克隆分析和条形码等技术正在揭示肿瘤进化、分化、miRNA控制和表观遗传学之间的相互作用。这是一个在理解癌症干细胞生物学方面取得快速进步的时代，具有造福人类健康的巨大潜力，这是一个与国家癌症研究所的使命明确相关的课题。