Cancer Pathophysiology: Integrating the Host and Tumor Environments

癌症病理生理学：整合宿主和肿瘤环境

• 批准号: 8985958
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.7万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2016-11-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8985958
• 关键词: Adipocytes; Basic Science; Biology; Breast; Cancer Biology; Cells; Clinical; Collaborations; Collagen; Colorado; Development; Diagnostic Neoplasm Staging; Discipline; Disease Progression; Environment; Fibroblasts; Functional disorder; Immune; Immune Targeting; Individual; International; Knowledge; Lead; Malignant Conversion; Malignant Neoplasms; Mentors; Methodology; Modality; Neoplasm Metastasis; Normal Cell; Outcome; Play; Process; Research; Research Personnel; Role; Science; Scientist; Therapeutic; Tissues; anticancer research; base; bone; clinical practice; cytotoxic; forging; interest; meetings; neoplastic cell; next generation; novel therapeutic intervention; novel therapeutics; paracrine; physical property; posters; public health relevance; symposium; therapeutic target; therapy resistant; tumor; tumor microenvironment; tumor progression; tumorigenesis; tumorigenic

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Cancer Pathophysiology: Integrating the Host and Tumor Environments, organized by Sheila A. Stewart, Sandra S. McAllister and Lisa M. Coussens. The meeting will be held in Breckenridge, Colorado from March 28-April 2, 2016. The local and systemic tumor microenvironments (TME) play a pivotal role in all stages of cancer development, including initiation, malignant conversion and metastasis, as well as regulating how neoplastic cells respond to cytotoxic, targeted and immune-based therapies. Research over the last decade has revealed the incredible diversity and plasticity that constitute the TME. Thus, the focus of this meeting will be to bring together a wide range of experts who focus on the various aspects of the TME with the intent of creating a more complete picture of the potential therapeutic landscape. The unique feature of this meeting is its breadth of experts focused on both the systemic and local TME, who also recognize varied paracrine interactions with heterogeneous neoplastic cells. Presentations will focus on emerging studies, enabling attendee's access to senior investigators, as well as new investigators spanning the diversity of disciplines called "cancer biology."

 描述（由申请人提供）：请求支持由 Sheila A. Stewart、Sandra S. McAllister 和 Lisa M. Coussens 组织的题为“癌症病理生理学：整合宿主和肿瘤环境”的 Keystone 研讨会。会议将于2016年3月28日至4月2日在科罗拉多州布雷肯里奇举行。局部和全身肿瘤微环境（TME）在癌症发展的各个阶段都发挥着关键作用，包括起始、恶性转化和转移，以及调节肿瘤细胞对细胞毒性、靶向和免疫疗法的反应。过去十年的研究揭示了 TME 令人难以置信的多样性和可塑性。因此，本次会议的重点将是聚集广泛的专家，他们关注 TME 的各个方面，旨在更全面地了解潜在的治疗前景。这次会议的独特之处在于其专家广泛关注全身和局部 TME，他们也认识到与异质肿瘤细胞的各种旁分泌相互作用。演讲将重点关注新兴研究，使与会者能够接触到高级研究人员以及跨越“癌症生物学”等不同学科的新研究人员。