Cancer Pathophysiology: Integrating the Host and Tumor Environments

 描述(由申请人提供)：申请支持由Sheila A.Stewart、Sandra S.McAllister和Lisa M.Coussens组织的题为癌症病理生理学：整合宿主和肿瘤环境的Keystone研讨会。会议将于2016年3月28日至4月2日在科罗拉多州布雷肯里奇举行。局部和全身肿瘤微环境(TME)在肿瘤发生、恶性转化和转移的所有阶段都起着关键作用，并调节肿瘤细胞对细胞毒、靶向和免疫基础治疗的反应。过去十年的研究揭示了构成TME的令人难以置信的多样性和可塑性。因此，这次会议的重点将是聚集广泛的专家，他们专注于TME的各个方面，目的是创建一个更完整的潜在治疗图景。这次会议的独特之处在于其广泛的专家专注于全身和局部的TME，他们也认识到不同的旁分泌与异质肿瘤细胞的相互作用。演讲将集中在新兴的研究上，使与会者能够接触到高级研究人员，以及跨越被称为“癌症生物学”的不同学科的新调查人员。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Cancer Pathophysiology: Integrating the Host and Tumor Environments, organized by Sheila A. Stewart, Sandra S. McAllister and Lisa M. Coussens. The meeting will be held in Breckenridge, Colorado from March 28-April 2, 2016. The local and systemic tumor microenvironments (TME) play a pivotal role in all stages of cancer development, including initiation, malignant conversion and metastasis, as well as regulating how neoplastic cells respond to cytotoxic, targeted and immune-based therapies. Research over the last decade has revealed the incredible diversity and plasticity that constitute the TME. Thus, the focus of this meeting will be to bring together a wide range of experts who focus on the various aspects of the TME with the intent of creating a more complete picture of the potential therapeutic landscape. The unique feature of this meeting is its breadth of experts focused on both the systemic and local TME, who also recognize varied paracrine interactions with heterogeneous neoplastic cells. Presentations will focus on emerging studies, enabling attendee's access to senior investigators, as well as new investigators spanning the diversity of disciplines called "cancer biology."