Xavier RCMI Center for Cancer Research

简介(申请人提供)：泽维尔大学RCIVII癌症研究中心自2009年成立以来，一直是实现该大学成为全国癌症和健康差距研究领先者的目标的推动力。为了更接近实现这一目标，我们提出了五项施舍。(1)加强内部和外部的合作和伙伴关系，特别是那些促进健康差距和转化性研究的合作和伙伴关系：通过路易斯安那州癌症研究联盟和路易斯安那州生物医学研究网络的积极伙伴关系，在与路易斯安那州立大学、路易斯安那州立大学健康科学中心、杜兰大学和彭宁顿生物医学研究中心现有合作的基础上，我们将利用现有的研究和指导资源，并通过Xille内部以及Xille和RTRN机构之间形成的伙伴关系建立新的合作伙伴关系。(2)重组和加强关键核心设施：我们将精简一个现有核心设施，创建一个新的药物发现和交付核心，并在我们现有的细胞和分子生物学核心基础上增加一个生物信息学设施。(3)增加泽维尔参与转化研究“管道”的富有竞争力和生产力的癌症和健康差距研究人员队伍：我们将保留以前聘用的、现在具有竞争力的RCMI教师，在关键的“差距”领域聘请更多有前途的初级教师，以提高我们在健康差距和转化研究方面的能力，并为这些教师提供成为/保持竞争力所必需的资源。(4)建立新的癌症/健康差异研究试点项目计划：我们将使用同行评议机制来选择将增加Xavier NIH R01和其他R系列拨款的项目，并支持试点转化研究项目进行初步数据收集。(5)有针对性地提供 支持RCMI研究人员的行政服务：我们将确保以最小的负担满足教师需求，将研究计划和核心服务整合在一起，并鼓励团队合作，确保教师发展计划促进专业成长，并参与健康差距和转化性研究。成功完成这些目标将具有重大意义，因为它将增加研究人员的队伍，他们可以更快地将板凳发现转化为公共利益，特别是在少数族裔社区。目前RCMI提案支持的研究项目将是创新的，因为我们建议利用一个方案结构，包括与主要研究型大学的伙伴关系，NIH支持的少数民族健康和健康差距中心，以及NIH资助的翻译科学中心。

DESCRIPTION (provided by applicant): Since its inception in 2009, Xavier University's RCIVII Center for Cancer Research has been a driving force toward achieving the University's goal of becoming a national leader in cancer and health disparities research. We propose five alms in order to move closer to attaining this goal. (1) Strengthen internal and external collaborations and partnerships, particularly those that promote health disparities and translational research: building on existing collaborations with LSU, LSU Health Sciences Center, Tulane University and the Pennington Biomedical Research Center through active partnerships in the Louisiana Cancer Research Consortium and the Louisiana Biomedical Research Network, we will leverage research and mentoring resources in place and establish new ones via partnerships formed within Xavier and between Xavier and RTRN institutions. (2) Reorganize and enhance critical core facilities: we will down size one existing core, create a new core in drug discovery and delivery and add -a bioinformatics facility to our existing Cell and Molecular Biology Core. (3) Increase Xavier's pool of competitive and productive cancer and health disparities researchers who participate in the translational research "pipeline:" we will retain previously hired, now competitive, RCMI faculty, hire additional promising junior faculty in critical "gap" areas that will improve our capabilities in health disparities and translational research, and provide these faculty with the resources necessary to become/remain competitive. (4)Establish a new pilot project program for cancer/health disparities research: we will use a peer-reviewed mechanism to select projects that will increase Xavier NIH R01 and other R-series grants and support pilot translational research projects for preliminary data collection. (5) Provide targeted administrative services in support of RCMI investigators: we will assure that faculty needs are met with minimal burden, research programs and core services are integrated and encourage teamwork, and that faculty development programs promote professional growth and engagement in health disparities and translational research. Successfully completing these aims will be significant because it will increase the pool of researchers who can more quickly translate bench discoveries into public benefit, particularly in minority communities. The research projects supported by the present RCMI proposal will be innovative as we propose to utilize a programmatic structure involving partnerships with major research universities, an NIH-supported Center for Minority Health and Health Disparities and an NIH-funded center for translational sciences.