Tools for Dissecting Proximal and Distal CA1 Contributions to Learning and Memory
用于剖析近端和远端 CA1 对学习和记忆贡献的工具
基本信息
- 批准号:9455391
- 负责人:
- 金额:$ 18.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-25 至 2019-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdenovirusesAffectAlzheimer&aposs DiseaseAnatomyAnimalsAnxietyAreaBasic ScienceBehaviorBehavioralCellsClinicalCommunicationDataDisease modelDistalDorsalEnvironmentEpilepsyEventExhibitsFragile X SyndromeGene ExpressionGeneticGoalsHippocampus (Brain)HumanInfusion proceduresLasersLateralLeadLearningLocationLoxP-flanked alleleMedialMemoryMemory DisordersMemory impairmentMental DepressionMental HealthMethodsModelingMusNeurobiologyNeurofibromatosesNeuronsOpsinOutputPathologyPathway interactionsPharmaceutical PreparationsPharmacologyPreventionResearch PersonnelRett SyndromeSeriesSignal PathwaySpecific qualifier valueStrokeStructureSystemTestingTimeTissuesTransgenic MiceTransgenic OrganismsTraumatic Brain InjuryTuberous SclerosisViralVisuospatialanimal databasecommunication behaviorconditioned feardesignentorhinal cortexexperimental studyhippocampal pyramidal neuronhuman datahuman diseaseimprovedinsightmemory consolidationmemory encodingmouse modelnervous system disordernovelobject recognitionoptogeneticspre-clinicalpreventpromoterselective expressiontoolway finding
项目摘要
Project Summary
Human and animal data indicate that the hippocampus encodes events and the spatial context in which they
occur. To understand how this is accomplished, we will use a systems-level approach that compares and
contrasts the function of specialized microcircuits within the mouse hippocampus. We will focus on the
proximal and distal segments of CA1, which are thought to encode an animal’s spatial location and the location
of objects in the environment. To control the activity of these regions during behavior, we will develop new
genetic tools that can be used to express the inhibitory opsin ArchT in specified segments of CA1. Targeted
laser stimulation will then be used to silence these segments during newly developed place and object learning
tasks. We predict that visuospatial learning will require activity in proximal CA1 while object learning will
require activity in distal CA1. The information gained from these analyses will improve our models of
hippocampal organization and allow us to better understand how this structure stores and retrieves distinct
types of memory. In addition, these tools can be used in mouse models of human disease to modify activity or
control gene expression in distinct segments of the hippocampus.
项目摘要
人类和动物的数据表明,海马体编码的事件和空间的背景下,他们
发生.为了理解这是如何实现的,我们将使用一种系统级的方法,
对比了老鼠海马体内专门微电路的功能。重点抓好
CA1的近端和远端段,被认为编码动物的空间位置和位置
环境中的物体。为了控制这些区域在行为过程中的活动,我们将开发新的
可用于在CA 1的指定片段中表达抑制性视蛋白ArchT的遗传工具。针对性
然后,在新开发的位置和物体学习过程中,激光刺激将用于使这些部分沉默
任务我们预测,视觉空间学习将需要近端CA1的活动,而物体学习将需要近端CA1的活动。
需要远端CA1的活性。从这些分析中获得的信息将改进我们的模型,
海马组织,让我们更好地了解这个结构如何存储和检索不同的
记忆的类型。此外,这些工具可用于人类疾病的小鼠模型中,以改变活性或功能。
控制海马体不同部分的基因表达。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brian J Wiltgen其他文献
Brian J Wiltgen的其他文献
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{{ item.author }}
{{ truncateString('Brian J Wiltgen', 18)}}的其他基金
The role of novelty and surprise in aversive conditioning
新奇和惊喜在厌恶性条件反射中的作用
- 批准号:
10682277 - 财政年份:2023
- 资助金额:
$ 18.52万 - 项目类别:
Influence of the locus coeruleus on fear learning and threat processing in the ventral hippocampus
蓝斑对腹侧海马恐惧学习和威胁处理的影响
- 批准号:
10552594 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
The contribution of the hippocampus to learned opiate tolerance
海马体对习得阿片耐受性的贡献
- 批准号:
10586097 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
The role of novelty and surprise in aversive conditioning
新奇和惊喜在厌恶性条件反射中的作用
- 批准号:
10626682 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
The contribution of the hippocampus to learned opiate tolerance
海马体对习得阿片耐受性的贡献
- 批准号:
10392284 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
Influence of the locus coeruleus on fear learning and threat processing in the ventral hippocampus
蓝斑对腹侧海马恐惧学习和威胁处理的影响
- 批准号:
10391884 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
Neurobiological Mechanisms of Systems Consolidation
系统整合的神经生物学机制
- 批准号:
9070016 - 财政年份:2015
- 资助金额:
$ 18.52万 - 项目类别:
Motivational control of goal-directed actions and habits
对目标导向的行为和习惯的动机控制
- 批准号:
7876013 - 财政年份:2010
- 资助金额:
$ 18.52万 - 项目类别:
Memory following CaMKII Loss in Hippocampal Subregions
海马分区 CaMKII 丢失后的记忆
- 批准号:
7007255 - 财政年份:2004
- 资助金额:
$ 18.52万 - 项目类别:
Memory following CaMKII Loss in Hippocampal Subregions
海马分区 CaMKII 丢失后的记忆
- 批准号:
6738530 - 财政年份:2004
- 资助金额:
$ 18.52万 - 项目类别:
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