Memory following CaMKII Loss in Hippocampal Subregions
海马分区 CaMKII 丢失后的记忆
基本信息
- 批准号:7007255
- 负责人:
- 金额:$ 4.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-01-01 至 2006-12-31
- 项目状态:已结题
- 来源:
- 关键词:behavior testbiological modelscalmodulin dependent protein kinaseconditioningdentate gyruselectrophysiologyenzyme activitygene deletion mutationgene targetinghippocampuslearninglong term potentiationmemorymolecular biologymolecular psychobiologyneural plasticityneurochemistrypostdoctoral investigatorprotein structure functionpsychobiologytissue /cell culturetransfection /expression vector
项目摘要
DESCRIPTION (provided by applicant): These studies are designed to determine the role of alpha-CaMKII in memory formation. Specifically, the effects of alpha-CaMKII deletion in distinct hippocampus subregions (CA1, dentate gyrus) will be examined. Deletion of alpha-CAMKII will be accomplished using contemporary knockout technology and targeted viral-vector infusions. Electrophysiological analyses will determine the effects of alpha-CaMKII deletion on long-term potentiation (LTP), a cellular model of learning and memory. Behavioral analyses will examine the effects of alpha-CaMKII loss on specific mnemonic functions mediated by each hippocampus subregion. The ultimate goal of these studies is to further our understanding of the molecular mechanisms that underlie memory formation in humans. Hippocampal dysfunction caused by disease (e.g., Alzheimer's, Korsakoff's), aging or damage produces severe memory loss. Understanding the molecular mechanisms that underlie hippocampus-dependent memory formation should provide insight into disorders caused by the dysfunction of this brain region.
描述(由申请人提供):这些研究旨在确定α-CaMKII在记忆形成中的作用。具体而言,将检查不同海马亚区(CA 1,齿状回)中α-CaMK II缺失的影响。将使用当代敲除技术和靶向病毒载体输注来完成α-CAMKII的缺失。电生理学分析将确定α-CaMKII缺失对长时程增强(LTP)(学习和记忆的细胞模型)的影响。行为分析将检查α-CaMKII损失对每个海马子区域介导的特定记忆功能的影响。这些研究的最终目标是进一步了解人类记忆形成的分子机制。由疾病引起的海马功能障碍(例如,老年痴呆症、科萨科夫症)、衰老或损伤会导致严重的记忆丧失。了解依赖于大脑皮层的记忆形成的分子机制,将有助于我们深入了解这一大脑区域功能障碍所导致的疾病。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The hippocampus plays a selective role in the retrieval of detailed contextual memories.
- DOI:10.1016/j.cub.2010.06.068
- 发表时间:2010-08-10
- 期刊:
- 影响因子:9.2
- 作者:Wiltgen, Brian J.;Zhou, Miou;Cai, Ying;Balaji, J.;Karlsson, Mikael Guzman;Parivash, Sherveen N.;Li, Weidong;Silvaz, Alcino J.
- 通讯作者:Silvaz, Alcino J.
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Brian J Wiltgen其他文献
Brian J Wiltgen的其他文献
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{{ truncateString('Brian J Wiltgen', 18)}}的其他基金
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Influence of the locus coeruleus on fear learning and threat processing in the ventral hippocampus
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The contribution of the hippocampus to learned opiate tolerance
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The role of novelty and surprise in aversive conditioning
新奇和惊喜在厌恶性条件反射中的作用
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10626682 - 财政年份:2022
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The contribution of the hippocampus to learned opiate tolerance
海马体对习得阿片耐受性的贡献
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10392284 - 财政年份:2022
- 资助金额:
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Influence of the locus coeruleus on fear learning and threat processing in the ventral hippocampus
蓝斑对腹侧海马恐惧学习和威胁处理的影响
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Tools for Dissecting Proximal and Distal CA1 Contributions to Learning and Memory
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Memory following CaMKII Loss in Hippocampal Subregions
海马分区 CaMKII 丢失后的记忆
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6738530 - 财政年份:2004
- 资助金额:
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