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Pharmacology of Lifespan Extension

Pharmacology of Lifespan Extension
延长寿命的药理学
批准号：
9521330
负责人：
Julie Kay Andersen
金额：
$19.4万
依托单位：
BUCK INSTITUTE FOR RESEARCH ON AGING
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-02-15 至 2019-04-30
来源：
https://reporter.nih.gov/project-details/9521330
关键词：
Age of OnsetAgingAnimal ModelBiochemicalCaenorhabditisCaenorhabditis elegansCell LineChemicalsCholecalciferolChronic DiseaseClinical ResearchClinical TrialsCommunitiesDevelopmentDiseaseDoseDrug ModelingsElderlyEndoplasmic ReticulumExhibitsFunctional disorderFutureGeneticHealthHomeostasisIncidenceInterventionLeadLinkLongevityLongevity PathwayMammalian CellMammalsModelingNatural ProductsNematodaNeurodegenerative DisordersPathologyPathway interactionsPharmaceutical PreparationsPharmacologyPhenotypePlayPopulationPreventionPreventive therapyProteinsPublic HealthResearchRoleSecosteroidsSeriesStructureTechnologyTestingVitamin DVitamin D DeficiencyWorkage relatedamyloid formationcompound 30drug discoveryhigh throughput screeningimprovednovelpre-clinicalpre-clinical researchpreventprotein structureproteostasispublic health relevanceresponsesmall moleculesmall molecule librariessuccessful interventiontherapy outcometranslational study

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中文摘要
翻译
描述（由申请人提供）：我们发现了一系列化合物，可以延缓与年龄有关的病理的发生，延长寿命。这些化合物在合成化合物和天然产物的集中化学筛选和高通量筛选中被鉴定出来。在这里，我们建议确定延长寿命的机制，重点是维生素D，我们已经证明维持蛋白质稳态并延长秀丽隐杆线虫的寿命。这将揭示干预衰老和年龄相关疾病的新机制。
英文摘要
DESCRIPTION (provided by applicant): We have discovered a series of chemical compounds that delay the onset of age-related pathology and extend lifespan. These compounds were identified in focused chemical screens and high throughput screens of both synthetic compounds and natural products. Here we propose to identify the mechanism of lifespan extension with a focus on vitamin D which we have shown maintains protein homeostasis and extends lifespan in C. elegans. This will uncover novel mechanisms for interventions in aging and age-related disease.
期刊论文(7)
专著(0)
科研奖励(0)
会议论文
Iron promotes protein insolubility and aging in C. elegans.
DOI： 10.18632/aging.100689
发表时间： 2014-11
期刊： Aging
影响因子： --
作者： [Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, Lithgow GJ]
通讯作者： Lithgow GJ
Kavain suppresses human Aβ-induced paralysis in C. elegans.
Kavain 抑制人 Aβ 诱导的线虫麻痹。
DOI： 10.17912/micropub.biology.000254
发表时间： 2020
期刊： microPublication biology
影响因子： --
作者： [Chamoli,Manish, Chinta,ShankarJ, Andersen,JulieK, Lithgow,GordonJ]
通讯作者： Lithgow,GordonJ
Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.
DOI： 10.1016/j.celrep.2016.09.086
发表时间： 2016-10-25
期刊： Cell reports
影响因子： 8.8
作者： [Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow GJ]
通讯作者： Lithgow GJ
Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.
DOI： 10.1371/journal.pone.0153513
发表时间： 2016
期刊： PloS one
影响因子： 3.7
作者： [Kumar J, Barhydt T, Awasthi A, Lithgow GJ, Killilea DW, Kapahi P]
通讯作者： Kapahi P
Novel mitochondria-to-lysosome crosstalk contributes to lysosomal dysfunction during aging
Neuronal FXR as a potential therapeutic target for Alzheimer's disease
Cellular senescence and Alzheimer's disease
Neuronal FXR as a potential therapeutic target for Alzheimer's disease
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