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Pharmacology of Lifespan Extension

延长寿命的药理学

基本信息

批准号：
9521330
负责人：
Julie Kay Andersen
金额：
$ 19.4万
依托单位：
BUCK INSTITUTE FOR RESEARCH ON AGING
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-02-15 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9521330
关键词：
Age of Onset Aging Animal Model Biochemical Caenorhabditis Caenorhabditis elegans Cell Line Chemicals Cholecalciferol Chronic Disease Clinical Research Clinical Trials Communities Development Disease Dose Drug Modelings Elderly Endoplasmic Reticulum Exhibits Functional disorder Future Genetic Health Homeostasis Incidence Intervention Lead Link Longevity Longevity Pathway Mammalian Cell Mammals Modeling Natural Products Nematoda Neurodegenerative Disorders Pathology Pathway interactions Pharmaceutical Preparations Pharmacology Phenotype Play Population Prevention Preventive therapy Proteins Public Health Research Role Secosteroids Series Structure Technology Testing Vitamin D Vitamin D Deficiency Work age related amyloid formation compound 30 drug discovery high throughput screening improved novel pre-clinical pre-clinical research prevent protein structure proteostasis public health relevance response small molecule small molecule libraries successful intervention therapy outcome translational study

项目摘要

DESCRIPTION (provided by applicant): We have discovered a series of chemical compounds that delay the onset of age-related pathology and extend lifespan. These compounds were identified in focused chemical screens and high throughput screens of both synthetic compounds and natural products. Here we propose to identify the mechanism of lifespan extension with a focus on vitamin D which we have shown maintains protein homeostasis and extends lifespan in C. elegans. This will uncover novel mechanisms for interventions in aging and age-related disease.

描述（由申请人提供）：我们已经发现了一系列化学化合物，可以延迟与年龄相关的病理学的发作并延长寿命。这些化合物在合成化合物和天然产物的集中化学筛选和高通量筛选中鉴定。在这里，我们建议确定寿命延长的机制，重点是维生素D，我们已经证明维生素D可以维持蛋白质稳态并延长C中的寿命。优美的这将揭示干预衰老和年龄相关疾病的新机制。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Iron promotes protein insolubility and aging in C. elegans.

DOI：
10.18632/aging.100689
发表时间：
2014-11
期刊：
Aging
影响因子：
0
作者：
Klang IM;Schilling B;Sorensen DJ;Sahu AK;Kapahi P;Andersen JK;Swoboda P;Killilea DW;Gibson BW;Lithgow GJ
通讯作者：
Lithgow GJ

Kavain suppresses human Aβ-induced paralysis in C. elegans.

Kavain 抑制人 Aβ 诱导的线虫麻痹。

DOI：
10.17912/micropub.biology.000254
发表时间：
2020
期刊：
microPublication biology
影响因子：
0
作者：
Chamoli,Manish;Chinta,ShankarJ;Andersen,JulieK;Lithgow,GordonJ
通讯作者：
Lithgow,GordonJ

Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.

DOI：
10.1016/j.celrep.2016.09.086
发表时间：
2016-10-25
期刊：
Cell reports
影响因子：
8.8
作者：
Mark KA;Dumas KJ;Bhaumik D;Schilling B;Davis S;Oron TR;Sorensen DJ;Lucanic M;Brem RB;Melov S;Ramanathan A;Gibson BW;Lithgow GJ
通讯作者：
Lithgow GJ

Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.