Tumor Immunology Training Program

肿瘤免疫学培训项目

• 批准号: 9330797
• 负责人: KENNETH Lynn WRIGHT
• 金额: $ 37.29万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330797
• 关键词: Training Programs; tumor immunology

DESCRIPTION (provided by applicant): This T32 application, begun in 2006 at the NCI-designated Comprehensive Moffitt Cancer Center, has the goal to train the next generation of leaders in translational immunology who can bridge bench work to clinical practice that leads to novel strategies to combat cancer. It aims to train a total of 2 predoctoral and 8 postdoctoral fellows, each for 3 years. Training is under 16 outstanding faculty members comprising of a mix of basic and clinical investigators who have a history of working together to solve barriers to immunity against cancer. Three areas of focus 1) innate immunity, inflammation and cancer, 2) adaptive immunity 3) immunotherapeutic strategies in cancer patients, integrate the research efforts of the faculty, which provide a multidisciplinary environment that benefit trainees for transition from mouse to man research. To take advantage of this setting, the Ph.D. Program in Cancer Biology, in its 10th year, has a curriculum that minimizes coursework and emphasizes laboratory research on a project co-mentored by a basic scientist and a physician scientist. Postdoctoral candidates also design a co- mentored project that addresses a critical issue in cancer immunity. The training program is overseen by the Education Committee headed by the PI with a faculty member from each of the 3 focus areas. It includes structured coursework, taken as appropriate, supplemented by participation in Research-in- Progress Seminars, Basic and Clinical Grand Rounds from outside speakers, and presentations at national meetings. Mandatory classes related to Research Ethics, Animal Safety and Human Subjects are taken, including training in key Core Facilities, such as Cell Therapies Core, Animal Models and Imaging, Flow Cytometry, Genomics, Proteomics, to enable trainees to utilize these tools in their research. The program is regularly evaluated under a process that measures not only the progress of the trainee but also the effectiveness of the program. Trainees working side by side with clinical mentors and their medical staff in the hospital setting will gain the necessary skill to conduct research in the interface of basic science and medicine.

描述（由申请人提供）：该T32应用程序于2006年在NCI指定的综合莫菲特癌症中心开始，目标是培养下一代翻译免疫学领导者，他们可以将实验室工作与临床实践联系起来，从而产生对抗癌症的新策略。它的目标是培养2名博士前研究员和8名博士后研究员，每人为期3年。培训不到16名优秀的教师，包括基础和临床研究人员，他们有共同努力解决癌症免疫障碍的历史。三个重点领域1）先天免疫，炎症和癌症，2）适应性免疫3）癌症患者的免疫策略，整合了教师的研究工作，提供了一个多学科的环境，有利于学员从小鼠到人的研究过渡。为了利用这一优势，博士。癌症生物学计划，在其第10年，有一个课程，最大限度地减少课程作业，并强调实验室研究的项目共同指导的基础科学家和医生科学家。博士后候选人还设计了一个共同指导的项目，解决了癌症免疫的一个关键问题。培训计划由PI领导的教育委员会监督，三个重点领域各有一名教员。它包括结构化的课程，酌情采取，通过参与研究进展中的研讨会，基本和临床大圆桌会议从外部发言者，并在国家会议上介绍补充。与研究伦理，动物安全和人类受试者相关的必修课，包括关键核心设施的培训，如细胞治疗核心，动物模型和成像，流式细胞术，基因组学，蛋白质组学，使学员能够在他们的研究中利用这些工具。该方案定期评估的过程中，不仅措施的进步，而且还计划的有效性。实习生与临床导师及其医务人员在医院环境中并肩工作，将获得必要的技能，在基础科学和医学的接口进行研究。

项目成果

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.

• DOI: 10.1016/j.molonc.2015.04.002
• 发表时间: 2015-08
• 期刊: Molecular oncology
• 影响因子: 6.6
• 作者: Woan KV;Lienlaf M;Perez-Villaroel P;Lee C;Cheng F;Knox T;Woods DM;Barrios K;Powers J;Sahakian E;Wang HW;Canales J;Marante D;Smalley KSM;Bergman J;Seto E;Kozikowski A;Pinilla-Ibarz J;Sarnaik A;Celis E;Weber J;Sotomayor EM;Villagra A
• 通讯作者: Villagra A

HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells.

• DOI: 10.1038/srep15085
• 发表时间: 2015-10-15
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Zhou J;Chen X;Gilvary DL;Tejera MM;Eksioglu EA;Wei S;Djeu JY
• 通讯作者: Djeu JY

Fighting Cancer with Mathematics and Viruses.

• DOI: 10.3390/v9090239
• 发表时间: 2017-08-23
• 期刊: Viruses
• 作者: Santiago DN;Heidbuechel JPW;Kandell WM;Walker R;Djeu J;Engeland CE;Abate-Daga D;Enderling H
• 通讯作者: Enderling H

Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression.

• DOI: 10.1615/critrevimmunol.v30.i5.30
• 发表时间: 2010
• 期刊: Critical reviews in immunology
• 影响因子: 1.3
• 作者: Mailloux AW;Young MR
• 通讯作者: Young MR

A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers.

• DOI: 10.1158/1078-0432.ccr-10-0733
• 发表时间: 2010-09-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Kodumudi KN;Woan K;Gilvary DL;Sahakian E;Wei S;Djeu JY
• 通讯作者: Djeu JY