Tumor Immunology Training Program

肿瘤免疫学培训项目

• 批准号: 9330797
• 负责人: KENNETH Lynn WRIGHT
• 金额: $ 37.29万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330797
• 关键词: Training Programs; tumor immunology

DESCRIPTION (provided by applicant): This T32 application, begun in 2006 at the NCI-designated Comprehensive Moffitt Cancer Center, has the goal to train the next generation of leaders in translational immunology who can bridge bench work to clinical practice that leads to novel strategies to combat cancer. It aims to train a total of 2 predoctoral and 8 postdoctoral fellows, each for 3 years. Training is under 16 outstanding faculty members comprising of a mix of basic and clinical investigators who have a history of working together to solve barriers to immunity against cancer. Three areas of focus 1) innate immunity, inflammation and cancer, 2) adaptive immunity 3) immunotherapeutic strategies in cancer patients, integrate the research efforts of the faculty, which provide a multidisciplinary environment that benefit trainees for transition from mouse to man research. To take advantage of this setting, the Ph.D. Program in Cancer Biology, in its 10th year, has a curriculum that minimizes coursework and emphasizes laboratory research on a project co-mentored by a basic scientist and a physician scientist. Postdoctoral candidates also design a co- mentored project that addresses a critical issue in cancer immunity. The training program is overseen by the Education Committee headed by the PI with a faculty member from each of the 3 focus areas. It includes structured coursework, taken as appropriate, supplemented by participation in Research-in- Progress Seminars, Basic and Clinical Grand Rounds from outside speakers, and presentations at national meetings. Mandatory classes related to Research Ethics, Animal Safety and Human Subjects are taken, including training in key Core Facilities, such as Cell Therapies Core, Animal Models and Imaging, Flow Cytometry, Genomics, Proteomics, to enable trainees to utilize these tools in their research. The program is regularly evaluated under a process that measures not only the progress of the trainee but also the effectiveness of the program. Trainees working side by side with clinical mentors and their medical staff in the hospital setting will gain the necessary skill to conduct research in the interface of basic science and medicine.

描述（由申请人提供）：这项T32申请于2006年在nci指定的综合莫菲特癌症中心开始，目标是培养下一代转化免疫学的领导者，他们可以将实验室工作与临床实践联系起来，从而产生对抗癌症的新策略。培养博士后2人，博士后8人，培养年限3年。培训由16名杰出的教师组成，其中包括基础和临床研究人员，他们有共同努力解决癌症免疫障碍的历史。三个重点领域1)先天免疫，炎症和癌症，2)适应性免疫，3)癌症患者的免疫治疗策略，整合了教师的研究成果，为学员从小鼠研究过渡到人类研究提供了一个多学科的环境。为了充分利用这种环境，已经进入第10个年头的癌症生物学博士课程将课程作业最小化，并强调由基础科学家和内科科学家共同指导的项目的实验室研究。博士后候选人还设计一个共同指导的项目，解决癌症免疫的关键问题。培训项目由PI领导的教育委员会监督，该委员会有来自三个重点领域的一名教员。它包括适当的结构化课程，辅以参加研究进展研讨会、外部演讲人的基础和临床大查房以及在国家会议上的报告。研究伦理、动物安全和人类受试者相关的必修课，包括关键核心设施的培训，如细胞治疗核心、动物模型和成像、流式细胞术、基因组学、蛋白质组学，使学员能够在他们的研究中使用这些工具。该项目定期进行评估，评估过程不仅衡量受训人员的进步，还衡量项目的有效性。实习生在医院与临床导师和他们的医务人员并肩工作，将获得在基础科学和医学界面进行研究的必要技能。

项目成果

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.

• DOI: 10.1016/j.molonc.2015.04.002
• 发表时间: 2015-08
• 期刊: Molecular oncology
• 影响因子: 6.6
• 作者: Woan KV;Lienlaf M;Perez-Villaroel P;Lee C;Cheng F;Knox T;Woods DM;Barrios K;Powers J;Sahakian E;Wang HW;Canales J;Marante D;Smalley KSM;Bergman J;Seto E;Kozikowski A;Pinilla-Ibarz J;Sarnaik A;Celis E;Weber J;Sotomayor EM;Villagra A
• 通讯作者: Villagra A

HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells.

• DOI: 10.1038/srep15085
• 发表时间: 2015-10-15
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Zhou J;Chen X;Gilvary DL;Tejera MM;Eksioglu EA;Wei S;Djeu JY
• 通讯作者: Djeu JY

Fighting Cancer with Mathematics and Viruses.

• DOI: 10.3390/v9090239
• 发表时间: 2017-08-23
• 期刊: Viruses
• 作者: Santiago DN;Heidbuechel JPW;Kandell WM;Walker R;Djeu J;Engeland CE;Abate-Daga D;Enderling H
• 通讯作者: Enderling H

Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression.

• DOI: 10.1615/critrevimmunol.v30.i5.30
• 发表时间: 2010
• 期刊: Critical reviews in immunology
• 影响因子: 1.3
• 作者: Mailloux AW;Young MR
• 通讯作者: Young MR

A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers.

• DOI: 10.1158/1078-0432.ccr-10-0733
• 发表时间: 2010-09-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Kodumudi KN;Woan K;Gilvary DL;Sahakian E;Wei S;Djeu JY
• 通讯作者: Djeu JY