Tumor Immunology Training Program

肿瘤免疫学培训项目

• 批准号: 9330797
• 负责人: KENNETH Lynn WRIGHT
• 金额: $ 37.29万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330797
• 关键词: Training Programs; tumor immunology

DESCRIPTION (provided by applicant): This T32 application, begun in 2006 at the NCI-designated Comprehensive Moffitt Cancer Center, has the goal to train the next generation of leaders in translational immunology who can bridge bench work to clinical practice that leads to novel strategies to combat cancer. It aims to train a total of 2 predoctoral and 8 postdoctoral fellows, each for 3 years. Training is under 16 outstanding faculty members comprising of a mix of basic and clinical investigators who have a history of working together to solve barriers to immunity against cancer. Three areas of focus 1) innate immunity, inflammation and cancer, 2) adaptive immunity 3) immunotherapeutic strategies in cancer patients, integrate the research efforts of the faculty, which provide a multidisciplinary environment that benefit trainees for transition from mouse to man research. To take advantage of this setting, the Ph.D. Program in Cancer Biology, in its 10th year, has a curriculum that minimizes coursework and emphasizes laboratory research on a project co-mentored by a basic scientist and a physician scientist. Postdoctoral candidates also design a co- mentored project that addresses a critical issue in cancer immunity. The training program is overseen by the Education Committee headed by the PI with a faculty member from each of the 3 focus areas. It includes structured coursework, taken as appropriate, supplemented by participation in Research-in- Progress Seminars, Basic and Clinical Grand Rounds from outside speakers, and presentations at national meetings. Mandatory classes related to Research Ethics, Animal Safety and Human Subjects are taken, including training in key Core Facilities, such as Cell Therapies Core, Animal Models and Imaging, Flow Cytometry, Genomics, Proteomics, to enable trainees to utilize these tools in their research. The program is regularly evaluated under a process that measures not only the progress of the trainee but also the effectiveness of the program. Trainees working side by side with clinical mentors and their medical staff in the hospital setting will gain the necessary skill to conduct research in the interface of basic science and medicine.

描述（由申请人提供）：该T32申请始于2006年在NCI指定的综合莫菲特癌症中心，其目标是培训转化免疫学领导者的下一代领导者，他们可以将基准工作桥接到临床实践上，从而导致新的策略，从而导致新颖的策略来对抗癌症。它旨在培训总共2个占5年和8个博士后研究员，分别为3年。培训是16位杰出的教职员工，其中包括基本和临床研究人员的组合，他们有共同努力解决癌症免疫障碍的历史。重点的三个领域1）先天免疫，炎症和癌症，2）适应性免疫3）癌症患者的免疫治疗策略，整合了教职员工的研究工作，该研究提供了一个多学科的环境，使受训者从小鼠到人类研究过渡。为了利用此设置，博士学位癌症生物学的计划在其第十个年度就有了一项课程，可最大程度地减少课程工作，并强调对基础科学家和医师科学家共同授予的项目的实验室研究。博士后候选人还设计了一个合作的项目，该项目解决了癌症免疫的关键问题。该培训计划由PI领导的教育委员会监督，由3个焦点领域的每个教职员工负责。它包括结构化的课程，适当地进行，并通过参与进度的研讨会，外部演讲者的基本和临床大回合以及在全国会议上的演讲进行补充。接受与研究伦理，动物安全和人类受试者有关的强制性类别，包括在关键核心设施中进行培训，例如细胞疗法核心，动物模型和成像，流式细胞仪，基因组学，蛋白质组学，以使学员能够在其研究中利用这些工具。该计划经常在一个过程中定期评估，该过程不仅衡量了学员的进度，还要衡量该计划的有效性。与临床导师及其医务人员并肩工作的学员将获得必要的技能，以在基础科学与医学界面进行研究。

项目成果

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.

• DOI: 10.1016/j.molonc.2015.04.002
• 发表时间: 2015-08
• 期刊: Molecular oncology
• 影响因子: 6.6
• 作者: Woan KV;Lienlaf M;Perez-Villaroel P;Lee C;Cheng F;Knox T;Woods DM;Barrios K;Powers J;Sahakian E;Wang HW;Canales J;Marante D;Smalley KSM;Bergman J;Seto E;Kozikowski A;Pinilla-Ibarz J;Sarnaik A;Celis E;Weber J;Sotomayor EM;Villagra A
• 通讯作者: Villagra A

HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells.

• DOI: 10.1038/srep15085
• 发表时间: 2015-10-15
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Zhou J;Chen X;Gilvary DL;Tejera MM;Eksioglu EA;Wei S;Djeu JY
• 通讯作者: Djeu JY

Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer.

• DOI: 10.1038/onc.2012.636
• 发表时间: 2014-02-06
• 期刊: Oncogene
• 影响因子: 8

A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers.

• DOI: 10.1158/1078-0432.ccr-10-0733
• 发表时间: 2010-09-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Kodumudi KN;Woan K;Gilvary DL;Sahakian E;Wei S;Djeu JY
• 通讯作者: Djeu JY

Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression.

• DOI: 10.1615/critrevimmunol.v30.i5.30
• 发表时间: 2010
• 期刊: Critical reviews in immunology
• 影响因子: 1.3
• 作者: Mailloux AW;Young MR
• 通讯作者: Young MR