Rapid Robust Pediatric MRI

快速稳健的儿科 MRI

• 批准号: 9754130
• 负责人: Michael Lustig
• 金额: $ 68.36万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754130
• 关键词: 3-Dimensional; Acoustics; Address; Adult; Algorithms; Anesthesia procedures; Body part; Bolus Infusion; Breathing; Child; Child Health; Childhood; Clinic; Clinical; Clinical Research; Computational Technique; Consumption; Contrast Media; Coupled; Data; Data Quality; Development; Diagnostic Imaging; Diffusion Magnetic Resonance Imaging; Disease; Ensure; Exposure to; Frequencies; Funding; Goals; Healthcare; Image; Image Compression; Image Enhancement; Injections; Ionizing radiation; Legal patent; Letters; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Methods; Modality; Morphologic artifacts; Motion; Motivation; Noise; Patients; Pediatric Oncology; Pediatrics; Population; Protocols documentation; Radiation; Resolution; Risk; Role; Running; Scanning; Speed; System; T2 weighted imaging; Techniques; Technology; Testing; Three-Dimensional Imaging; Time; Transplantation; Validation; Work; base; cancer risk; clinical practice; clinical translation; community setting; compliance behavior; contrast enhanced; design and construction; experience; high dimensionality; image reconstruction; imaging system; innovation; multidisciplinary; novel; off-patent; patient tolerability; pediatric patients; programs; radiation risk; reconstruction; skills; soft tissue; volunteer

Project Abstract Motivation: This is a competing renewal of our successful project, Rapid Robust Pediatric MRI, R01 EB009690. MRI offers superb soft tissue contrast for children, without the ionizing radiation and cancer risk of CT. However, MRI use has been limited due to long exams, low spatial resolution, and motion-artifacts. Thus, MRI often requires prolonged anesthesia with breath-holds and attendant risk; hence, children often lack the benefits of cross-sectional imaging altogether or are exposed to ionizing radiation. The previous project addressed these concerns by creating a dedicated pediatric imaging system. Highly par- allel, high-SNR 3T receive coil arrays were designed and constructed specifically for pediatric body imaging. The high SNR was used to accelerate scans reconstructed with a combination of parallel imaging, new mo- tion correction algorithms, compressed sensing (CS), and higher dimensional imaging. The resulting system is now being used extensively in clinical practice, significantly reducing anesthesia depth and duration, and has markedly increased our MRI utilization. Key technologies have been or are now being commercialized with GE Healthcare, including the pediatric receive array, CS, 4D flow, full-Fourier single-shot T2-weighted scanning, and coil compression. Siemens has licensed five of our patents, implemented them in work-in-progress packages, and productized our coil compression and our ESPIRiT coil sensitivity estimation. Philips has licensed three of our patents. This ensures broad impact. Approach: Despite significant progress and reduced anesthesia depth and duration, patient cooperation re- mains the main limitation to eliminate anesthesia in all pediatric body MRI exams. Many children will cooperate for several minutes, but then fidget and get out of the scanner. Others are content until acoustic noise agi- tates them. Therefore the major emphasis now is greater exam execution speed, comprehensive elimination of acoustic noise, and increased robustness, particularly to contrast agent injection. The project has three interrelated development aims, validated by clinical studies. Aim 1 will enable fast 2D imag- ing for quiet T2 and quiet low-distortion diffusion weighted imaging. A second aim is to develop free-breathing 3D contrast-enhanced and diffusion-weighted imaging that is silent and motion-robust. The third aim will enable au- tomated, smart scanning to speed the exam execution and adaptive protocols to increase the exam robustness. The impact of all of these developments in the clinic will then be assessed to assess the resulting reduction of anesthesia. Significance: This work will lead to fast, robust, broadly-applicable pediatric MRI protocols with less anes- thesia, making MRI safer, cheaper, and more available to children. MRI will be transformed into a workhorse modality, reducing CT radiation burden. The techniques will facilitate wide application in the community setting and permit new MRI applications, for both pediatric and adult diseases.

项目摘要 动机：这是我们成功项目快速稳健儿科 MRI R01 的竞争性更新 EB009690。 MRI 为儿童提供卓越的软组织对比度，没有电离辐射和癌症风险 CT 的。然而，由于检查时间长、空间分辨率低和运动伪影，MRI 的使用受到限制。因此， MRI 通常需要长时间麻醉并屏住呼吸，从而带来风险；因此，孩子们常常缺乏 完全横截面成像的好处或暴露于电离辐射。 之前的项目通过创建专用的儿科成像系统来解决这些问题。高度标准 等位基因、高信噪比 3T 接收线圈阵列专为儿科身体成像而设计和构建。 高信噪比用于加速扫描重建，结合并行成像、新的移动技术 化校正算法、压缩感知（CS）和高维成像。由此产生的系统是 现已广泛应用于临床实践，显着减少麻醉深度和持续时间，并已 显着提高了我们的 MRI 利用率。 关键技术已经或正在与 GE Healthcare 商业化，包括儿科接收 阵列、CS、4D 流、全傅里叶单次 T2 加权扫描和线圈压缩。西门子已获得授权 我们的五项专利，在正在进行的工作包中实施，并将我们的线圈压缩和 我们的 ESPIRiT 线圈灵敏度估计。飞利浦已授权我们的三项专利。这确保了广泛的影响。 方法：尽管取得了显着进展并减少了麻醉深度和持续时间，但患者的合作仍然存在 这是所有儿科身体 MRI 检查中消除麻醉的主要限制。很多孩子都会配合 几分钟，但随后坐立不安并离开扫描仪。其他人很满意，直到噪音agi- 泰特斯他们。所以现在的重点是提高考试执行速度，全面消除 噪音，并提高稳健性，特别是对比剂注射。 该项目具有三个相互关联的开发目标，并经过临床研究验证。目标 1 将实现快速 2D 成像 用于安静 T2 和安静低失真扩散加权成像。第二个目标是开发自由呼吸的 3D 对比度增强和扩散加权成像，安静且运动鲁棒。第三个目标将使au- 自动化的智能扫描可加快考试执行速度，自适应协议可提高考试的稳健性。 然后将评估所有这些发展对临床的影响，以评估由此产生的减少 麻醉。 意义：这项工作将带来快速、稳健、广泛适用的儿科 MRI 方案，且所需时间更少。 Thesia，使 MRI 更安全、更便宜，并且更适合儿童使用。 MRI 将转变为主力 方式，减少 CT 辐射负担。这些技术将促进在社区环境中的广泛应用 并允许针对儿科和成人疾病的新 MRI 应用。