Enabling the Next Generation of High Performance Pediatric Whole Body MR Imaging

实现下一代高性能儿科全身 MR 成像

• 批准号: 10436300
• 负责人: Michael Lustig
• 金额: $ 83.71万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436300
• 关键词: 10 year old; 8 year old; Acclimatization; Acoustics; Adult; Age; Anatomy; Anesthesia procedures; Body part; Caliber; Caregivers; Child; Child Health; Childhood; Cone; Coupled; Custom; Development; Diffusion Magnetic Resonance Imaging; Electrocardiogram; Electronics; Environment; Equipment; Flare; Goals; Head; Image; Immersion; Infrastructure; Machine Learning; Magnetic Resonance Imaging; Measures; Methods; Morphologic artifacts; Motion; Motivation; Noise; Partner in relationship; Patients; Pediatrics; Performance; Peripheral Nerve Stimulation; Physiologic pulse; Physiological; Preparation; Radiation; Resolution; Respiration; Role; Scanning; Signal Transduction; Speed; Support System; System; T2 weighted imaging; Techniques; Technology; Temperature; Testing; Thinness; Time; Vendor; base; brain magnetic resonance imaging; commercialization; contrast imaging; data acquisition; density; design; digital; experience; hemodynamics; image reconstruction; imaging capabilities; imaging system; improved; innovation; next generation; novel; novel strategies; open source; pediatric patients; reconstruction; respiratory; sensor; success; tool; virtual reality; whole body imaging

Project Abstract Motivation: We aim to develop and implement a new approach to transform pediatric MRI. The ultimate goal is ultra-fast and motion-robust imaging in a dedicated child-friendly environment to enable more children undergo MRI without anesthesia. For those who still require anesthesia, it will be briefer and lighter, and performed in a safer environment. This project leverages a small compact magnet, designed for adult brain MRI, with gradients that enable very fast imaging. With this magnet as an outstanding starting point, we will tailor our deep experience and multiple successes in developing new MRI approaches to high-density receiver coils, fast imaging sequences, and new image reconstruction methods to set a new standard for pediatric MRI. Approach: Although the compact scanner is designed for adult heads, with a 37 cm inner diameter, it can accommodate children under eight to ten years of age to image any body part. To transform this system for ideal pediatric scanning, three development aims will be pursued. The first is to enable optimal signal reception. This will be accomplished through creating new receive chain electronics that are matched to the gradient capabilities, for ultra-high bandwidth imaging. This will be coupled to very thin and formed receive arrays that maximize the size of the patient that can be accommodated in the small bore of the scanner. The second aim is to develop methods of obtaining the highest performance out of the system by characterizing and correcting for its imperfections. This will be coupled to a bespoke approach to peripheral nerve stimulation, enabling maximal use of the gradients on each patient. These two developments will then be leveraged for high efficiency and motion robust noncartesian scanning. The final aim is to develop a full environment and infrastructure that is well suited to pediatric imaging. Patient preparation and acclimation to MRI will be enhanced by virtual reality. Support equipment for anesthesia, new physiological sensors, and a novel child-friendly audiovisual system will be created. Significance: The result of this project will be a revolutionary change in the way that MRI is used and per- formed for children. MRI will be more available, cheaper, safer, and have markedly improved image quality.

项目摘要 动机：我们的目标是开发和实施一种新的方法来转变儿科MRI。最终目标是 在专门的儿童友好环境中提供超快和运动稳健的成像，使更多儿童能够 没有麻醉的核磁共振检查。对于那些仍然需要麻醉的人，它将更短、更轻，并进行 在一个更安全的环境中。该项目利用了一种小型紧凑型磁铁，专为成人大脑核磁共振而设计，具有 可实现快速成像的渐变。以这块磁铁为突出的起点，我们将量身定做我们的 在快速开发高密度接收器线圈的新MRI方法方面的丰富经验和多次成功 成像序列和新的图像重建方法为儿科MRI树立了新的标准。 方法：虽然紧凑型扫描仪是为成人头部设计的，内径为37厘米，但它可以 适合8到10岁以下的儿童想象身体的任何部位。将这一制度转变为理想 儿科扫描，将追求三个发展目标。fiRST是为了实现最佳信号接收。这 将通过创建与梯度能力匹配的新接收链电子设备来实现， 用于超高带宽成像。这将耦合到非常薄且形成的接收阵列，以最大化 扫描仪小孔中可以容纳的病人的大小。第二个目标是 开发方法以获得系统的最高性能，方法是通过表征和纠正 它的不完美。这将与定制的周围神经刺激方法相结合，使最大限度地 在每个病人身上使用渐变。这两个发展将被利用，以实现高效率的fi和 运动健壮的非笛卡尔扫描。fiNAL的目标是开发一个完整的环境和基础设施， 非常适合儿科成像。虚拟现实将加强患者对MRI的准备和适应。 麻醉辅助设备、新的生理传感器和新的儿童友好的视听系统将 被创造出来。 SignifiCance：这个项目的结果将是磁共振成像使用方式的革命性变化， 是为儿童而生的。核磁共振将更容易获得，更便宜，更安全，并显著提高图像质量。