Enabling the Next Generation of High Performance Pediatric Whole Body MR Imaging

实现下一代高性能儿科全身 MR 成像

• 批准号: 10436300
• 负责人: Michael Lustig
• 金额: $ 83.71万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436300
• 关键词: 10 year old; 8 year old; Acclimatization; Acoustics; Adult; Age; Anatomy; Anesthesia procedures; Body part; Caliber; Caregivers; Child; Child Health; Childhood; Cone; Coupled; Custom; Development; Diffusion Magnetic Resonance Imaging; Electrocardiogram; Electronics; Environment; Equipment; Flare; Goals; Head; Image; Immersion; Infrastructure; Machine Learning; Magnetic Resonance Imaging; Measures; Methods; Morphologic artifacts; Motion; Motivation; Noise; Partner in relationship; Patients; Pediatrics; Performance; Peripheral Nerve Stimulation; Physiologic pulse; Physiological; Preparation; Radiation; Resolution; Respiration; Role; Scanning; Signal Transduction; Speed; Support System; System; T2 weighted imaging; Techniques; Technology; Temperature; Testing; Thinness; Time; Vendor; base; brain magnetic resonance imaging; commercialization; contrast imaging; data acquisition; density; design; digital; experience; hemodynamics; image reconstruction; imaging capabilities; imaging system; improved; innovation; next generation; novel; novel strategies; open source; pediatric patients; reconstruction; respiratory; sensor; success; tool; virtual reality; whole body imaging

Project Abstract Motivation: We aim to develop and implement a new approach to transform pediatric MRI. The ultimate goal is ultra-fast and motion-robust imaging in a dedicated child-friendly environment to enable more children undergo MRI without anesthesia. For those who still require anesthesia, it will be briefer and lighter, and performed in a safer environment. This project leverages a small compact magnet, designed for adult brain MRI, with gradients that enable very fast imaging. With this magnet as an outstanding starting point, we will tailor our deep experience and multiple successes in developing new MRI approaches to high-density receiver coils, fast imaging sequences, and new image reconstruction methods to set a new standard for pediatric MRI. Approach: Although the compact scanner is designed for adult heads, with a 37 cm inner diameter, it can accommodate children under eight to ten years of age to image any body part. To transform this system for ideal pediatric scanning, three development aims will be pursued. The first is to enable optimal signal reception. This will be accomplished through creating new receive chain electronics that are matched to the gradient capabilities, for ultra-high bandwidth imaging. This will be coupled to very thin and formed receive arrays that maximize the size of the patient that can be accommodated in the small bore of the scanner. The second aim is to develop methods of obtaining the highest performance out of the system by characterizing and correcting for its imperfections. This will be coupled to a bespoke approach to peripheral nerve stimulation, enabling maximal use of the gradients on each patient. These two developments will then be leveraged for high efficiency and motion robust noncartesian scanning. The final aim is to develop a full environment and infrastructure that is well suited to pediatric imaging. Patient preparation and acclimation to MRI will be enhanced by virtual reality. Support equipment for anesthesia, new physiological sensors, and a novel child-friendly audiovisual system will be created. Significance: The result of this project will be a revolutionary change in the way that MRI is used and per- formed for children. MRI will be more available, cheaper, safer, and have markedly improved image quality.

项目摘要