Enabling the Next Generation of High Performance Pediatric Whole Body MR Imaging

实现下一代高性能儿科全身 MR 成像

基本信息

批准号：
10669157
负责人：
Michael Lustig
金额：
$ 82.02万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10669157
关键词：
10 year old 8 year old Acclimatization Acoustics Adult Age Anatomy Anesthesia procedures Body part Caregivers Child Child Health Childhood Cone Coupled Custom Dedications Development Diameter Diffusion Magnetic Resonance Imaging Electrocardiogram Electronics Environment Equipment Flare Friends Goals Head Image Infrastructure Machine Learning Magnetic Resonance Imaging Measures Methods Morphologic artifacts Motion Motivation Noise Patients Pediatrics Performance Peripheral Nerve Stimulation Physiologic pulse Physiological Preparation Radiation Resolution Respiration Role Scanning Signal Transduction Speed Support System System T2 weighted imaging Techniques Technology Temperature Testing Thinness Time Vendor brain magnetic resonance imaging commercialization contrast imaging correctional system data acquisition density design diagnostic platform digital experience hemodynamics image reconstruction imaging capabilities imaging system improved innovation next generation novel novel strategies open source pediatric patients reconstruction respiratory sensor success tool virtual reality whole body imaging

项目摘要

Project Abstract Motivation: We aim to develop and implement a new approach to transform pediatric MRI. The ultimate goal is ultra-fast and motion-robust imaging in a dedicated child-friendly environment to enable more children undergo MRI without anesthesia. For those who still require anesthesia, it will be briefer and lighter, and performed in a safer environment. This project leverages a small compact magnet, designed for adult brain MRI, with gradients that enable very fast imaging. With this magnet as an outstanding starting point, we will tailor our deep experience and multiple successes in developing new MRI approaches to high-density receiver coils, fast imaging sequences, and new image reconstruction methods to set a new standard for pediatric MRI. Approach: Although the compact scanner is designed for adult heads, with a 37 cm inner diameter, it can accommodate children under eight to ten years of age to image any body part. To transform this system for ideal pediatric scanning, three development aims will be pursued. The ﬁrst is to enable optimal signal reception. This will be accomplished through creating new receive chain electronics that are matched to the gradient capabilities, for ultra-high bandwidth imaging. This will be coupled to very thin and formed receive arrays that maximize the size of the patient that can be accommodated in the small bore of the scanner. The second aim is to develop methods of obtaining the highest performance out of the system by characterizing and correcting for its imperfections. This will be coupled to a bespoke approach to peripheral nerve stimulation, enabling maximal use of the gradients on each patient. These two developments will then be leveraged for high efﬁciency and motion robust noncartesian scanning. The ﬁnal aim is to develop a full environment and infrastructure that is well suited to pediatric imaging. Patient preparation and acclimation to MRI will be enhanced by virtual reality. Support equipment for anesthesia, new physiological sensors, and a novel child-friendly audiovisual system will be created. Signiﬁcance: The result of this project will be a revolutionary change in the way that MRI is used and per- formed for children. MRI will be more available, cheaper, safer, and have markedly improved image quality.

项目摘要动机：我们旨在开发和实施一种转化小儿MRI的新方法。最终目标是在专门的儿童友好环境中进行超快速和运动的成像，以使更多的孩子经历 MRI无麻醉。对于那些仍然需要麻醉的人，它将是英国人，更轻松，并且表演在安全的环境中。该项目利用一个小型紧凑型磁铁，专为成人脑MRI设计，并带有能够实现非常快速成像的渐变。以这款磁铁为出色的起点，我们将量身定制深厚的经验和在开发新的MRI方法的高密度接收器线圈方面取得的多重成功，快速成像序列和新图像重建方法为小儿MRI设定新标准。方法：尽管紧凑型扫描仪是为成人头设计的，但内径为37厘米，但可以住宿儿童八到十岁以下，以形象任何身体部位。转换该系统以建立理想小儿扫描，将追求三个开发目标。首先是实现最佳信号接收。这将通过创建与梯度功能相匹配的新接收链电子来完成用于超高的带宽成像。这将结合到非常薄并形成的接收阵列以最大化可以在扫描仪的小孔中容纳的患者大小。第二个目标是通过表征和纠正来开发从系统中获得最高性能的方法它的不完美。这将与定制的外围神经刺激的定制方法结合起来，使最大在每个患者上使用梯度。然后，这两个发展将用于高效效率，并运动强大的非室温扫描。最终目的是开发一个完整的环境和基础设施非常适合小儿成像。虚拟现实将增强患者的准备和对MRI的适应。麻醉，新的物理传感器和新颖的儿童友好视听系统的支持设备将被创建。意义：该项目的结果将是MRI的使用方式的革命性变化为儿童组成。 MRI将更可用，更便宜，更安全，并且明显提高了图像质量。