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Enabling the Next Generation of High Performance Pediatric Whole Body MR Imaging

实现下一代高性能儿科全身 MR 成像

基本信息

批准号：
10669157
负责人：
Michael Lustig
金额：
$ 82.02万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10669157
关键词：
10 year old 8 year old Acclimatization Acoustics Adult Age Anatomy Anesthesia procedures Body part Caregivers Child Child Health Childhood Cone Coupled Custom Dedications Development Diameter Diffusion Magnetic Resonance Imaging Electrocardiogram Electronics Environment Equipment Flare Friends Goals Head Image Infrastructure Machine Learning Magnetic Resonance Imaging Measures Methods Morphologic artifacts Motion Motivation Noise Patients Pediatrics Performance Peripheral Nerve Stimulation Physiologic pulse Physiological Preparation Radiation Resolution Respiration Role Scanning Signal Transduction Speed Support System System T2 weighted imaging Techniques Technology Temperature Testing Thinness Time Vendor brain magnetic resonance imaging commercialization contrast imaging correctional system data acquisition density design diagnostic platform digital experience hemodynamics image reconstruction imaging capabilities imaging system improved innovation next generation novel novel strategies open source pediatric patients reconstruction respiratory sensor success tool virtual reality whole body imaging

项目摘要

Project Abstract Motivation: We aim to develop and implement a new approach to transform pediatric MRI. The ultimate goal is ultra-fast and motion-robust imaging in a dedicated child-friendly environment to enable more children undergo MRI without anesthesia. For those who still require anesthesia, it will be briefer and lighter, and performed in a safer environment. This project leverages a small compact magnet, designed for adult brain MRI, with gradients that enable very fast imaging. With this magnet as an outstanding starting point, we will tailor our deep experience and multiple successes in developing new MRI approaches to high-density receiver coils, fast imaging sequences, and new image reconstruction methods to set a new standard for pediatric MRI. Approach: Although the compact scanner is designed for adult heads, with a 37 cm inner diameter, it can accommodate children under eight to ten years of age to image any body part. To transform this system for ideal pediatric scanning, three development aims will be pursued. The ﬁrst is to enable optimal signal reception. This will be accomplished through creating new receive chain electronics that are matched to the gradient capabilities, for ultra-high bandwidth imaging. This will be coupled to very thin and formed receive arrays that maximize the size of the patient that can be accommodated in the small bore of the scanner. The second aim is to develop methods of obtaining the highest performance out of the system by characterizing and correcting for its imperfections. This will be coupled to a bespoke approach to peripheral nerve stimulation, enabling maximal use of the gradients on each patient. These two developments will then be leveraged for high efﬁciency and motion robust noncartesian scanning. The ﬁnal aim is to develop a full environment and infrastructure that is well suited to pediatric imaging. Patient preparation and acclimation to MRI will be enhanced by virtual reality. Support equipment for anesthesia, new physiological sensors, and a novel child-friendly audiovisual system will be created. Signiﬁcance: The result of this project will be a revolutionary change in the way that MRI is used and per- formed for children. MRI will be more available, cheaper, safer, and have markedly improved image quality.

项目摘要动机：我们的目标是开发和实施一种新的方法来改造儿科MRI。最终目标是在专用的儿童友好环境中提供超快速和运动稳健的成像，使更多的儿童能够接受无麻醉MRI。对于那些仍然需要麻醉的人，它将更简短，更轻，并执行在一个更安全的环境中。该项目利用了一个小型紧凑型磁铁，专为成人大脑MRI，梯度可以实现非常快速的成像。有了这个磁铁作为一个突出的起点，我们将量身定制我们的在开发高密度接收线圈的新MRI方法方面拥有丰富的经验和多次成功，成像序列和新的图像重建方法，为儿科MRI设定新标准。方法：虽然紧凑型扫描仪是为成人头部设计的，内径为37厘米，但它可以允许8至10岁以下的儿童对身体的任何部位进行成像。把这个系统改造成理想的儿科扫描，将追求三个发展目标。第一是实现最佳信号接收。这将通过创建与梯度能力相匹配的新的接收链电子设备来实现，用于超高带宽成像。这将耦合到非常薄的和形成的接收阵列，扫描仪的小孔中可容纳的患者的尺寸。第二个目标是开发方法，通过表征和校正系统，它的缺陷。这将与定制的外周神经刺激方法相结合，在每个病人身上使用梯度。这两个发展将被用来提高效率，运动鲁棒非旋转扫描。最终目标是建立一个完整的环境和基础设施，非常适合儿科成像。虚拟现实将增强患者对MRI的准备和适应。支持设备麻醉，新的生理传感器，和一个新的儿童友好的视听系统将被创造出来。意义：该项目的结果将是MRI使用方式的革命性变化，为儿童而建。MRI将更容易获得，更便宜，更安全，并显着提高图像质量。