Rapid Robust Pediatric MRI

快速稳健的儿科 MRI

• 批准号: 9595406
• 负责人: Michael Lustig
• 金额: $ 70.33万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9595406
• 关键词: Acoustics; Address; Adult; Algorithms; Anesthesia procedures; Body Image; Body part; Bolus Infusion; Breathing; Child; Child Health; Childhood; Clinic; Clinical; Clinical Research; Computational Technique; Contrast Media; Coupled; Data; Data Quality; Development; Diagnostic Imaging; Diffusion Magnetic Resonance Imaging; Disease; Ensure; Exposure to; Frequencies; Funding; Goals; Healthcare; Image; Image Compression; Image Enhancement; Injections; Ionizing radiation; Legal patent; Letters; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Methods; Modality; Morphologic artifacts; Motion; Motivation; Noise; Patients; Pediatric Oncology; Pediatrics; Population; Protocols documentation; Radiation; Resolution; Risk; Role; Running; Scanning; Speed; System; T2 weighted imaging; Techniques; Technology; Testing; Three-Dimensional Imaging; Time; Transplantation; Validation; Work; base; cancer risk; clinical practice; clinical translation; community setting; compliance behavior; contrast enhanced; design and construction; experience; high dimensionality; image reconstruction; imaging system; innovation; multidisciplinary; novel; pediatric patients; programs; radiation risk; reconstruction; skills; soft tissue; volunteer

Project Abstract Motivation: This is a competing renewal of our successful project, Rapid Robust Pediatric MRI, R01 EB009690. MRI offers superb soft tissue contrast for children, without the ionizing radiation and cancer risk of CT. However, MRI use has been limited due to long exams, low spatial resolution, and motion-artifacts. Thus, MRI often requires prolonged anesthesia with breath-holds and attendant risk; hence, children often lack the benefits of cross-sectional imaging altogether or are exposed to ionizing radiation. The previous project addressed these concerns by creating a dedicated pediatric imaging system. Highly par- allel, high-SNR 3T receive coil arrays were designed and constructed specifically for pediatric body imaging. The high SNR was used to accelerate scans reconstructed with a combination of parallel imaging, new mo- tion correction algorithms, compressed sensing (CS), and higher dimensional imaging. The resulting system is now being used extensively in clinical practice, significantly reducing anesthesia depth and duration, and has markedly increased our MRI utilization. Key technologies have been or are now being commercialized with GE Healthcare, including the pediatric receive array, CS, 4D flow, full-Fourier single-shot T2-weighted scanning, and coil compression. Siemens has licensed five of our patents, implemented them in work-in-progress packages, and productized our coil compression and our ESPIRiT coil sensitivity estimation. Philips has licensed three of our patents. This ensures broad impact. Approach: Despite significant progress and reduced anesthesia depth and duration, patient cooperation re- mains the main limitation to eliminate anesthesia in all pediatric body MRI exams. Many children will cooperate for several minutes, but then fidget and get out of the scanner. Others are content until acoustic noise agi- tates them. Therefore the major emphasis now is greater exam execution speed, comprehensive elimination of acoustic noise, and increased robustness, particularly to contrast agent injection. The project has three interrelated development aims, validated by clinical studies. Aim 1 will enable fast 2D imag- ing for quiet T2 and quiet low-distortion diffusion weighted imaging. A second aim is to develop free-breathing 3D contrast-enhanced and diffusion-weighted imaging that is silent and motion-robust. The third aim will enable au- tomated, smart scanning to speed the exam execution and adaptive protocols to increase the exam robustness. The impact of all of these developments in the clinic will then be assessed to assess the resulting reduction of anesthesia. Significance: This work will lead to fast, robust, broadly-applicable pediatric MRI protocols with less anes- thesia, making MRI safer, cheaper, and more available to children. MRI will be transformed into a workhorse modality, reducing CT radiation burden. The techniques will facilitate wide application in the community setting and permit new MRI applications, for both pediatric and adult diseases.

项目摘要 动机：这是我们成功项目的竞争续约，快速鲁棒的小儿MRI，R01 EB009690。 MRI为儿童提供了极佳的软组织对比，而没有电离辐射和癌症风险 Ct。然而，由于长期检查，空间分辨率低和运动艺术，MRI使用受到限制。那， MRI通常需要长时间的麻醉，并带有呼吸和随之而来的风险；因此，孩子们经常缺乏 横截面成像的益处完全暴露于电离辐射。 以前的项目通过创建专用的儿科成像系统来解决这些问题。高度 - Allel，高-SNR 3T接收线圈阵列是设计和构造的，专门针对小儿体成像。 高SNR用于加速扫描，并结合平行成像，新的mo- 校正算法，压缩灵敏度（CS）和更高的尺寸成像。结果系统是 现在被广泛用于临床实践，显着降低了麻醉深度和持续时间，并且具有 明显增加了我们的MRI利用率。 关键技术已经或正在通过GE Healthcare商业化，包括儿科接收 阵列，CS，4D流量，全倍单发T2加权扫描和线圈压缩。西门子已获得许可 我们的五项专利，以进行工作的包裹实施它们，并生产我们的线圈压缩和 我们的Espirit线圈灵敏度估计。飞利浦已获得我们的三项专利许可。这确保了广泛的影响。 方法：尽管进展显着并减少了麻醉的深度和持续时间，但患者的合作恢复了 主要局限性消除所有儿科身体MRI检查中的麻醉。许多孩子会合作 几分钟，但随后要磨掉并摆脱扫描仪。其他人满足直到声学噪声agi- 抚摸他们。因此，现在的主要重点是更高的考试速度，全面消除 声学噪声和鲁棒性增加，尤其是对比剂注射。 该项目具有三个相互关联的开发目标，并通过临床研究验证。 AIM 1将启用快速的2D Imag- 为安静的T2和安静的低渗透扩散加权成像。第二个目的是开发自由呼吸3D 对比增强和扩散加权成像，无声和运动刺激性。第三个目标将使Au- 智能扫描，以加快考试的执行和自适应协议，以提高检查鲁棒性。 然后，将评估所有这些事态发展在诊所中的影响，以评估导致的减少 麻醉。 意义上：这项工作将导致快速，健壮，广泛适用的儿科MRI方案，而Anes较少 - Thesia，使MRI更安全，便宜，更便宜，并且可以为儿童使用。 MRI将转变为主力 模态，减少CT辐射伯嫩。这些技术将促进社区环境中的广泛应用 并允许为儿科和成人疾病提供新的MRI申请。