Rapid Robust Pediatric MRI

快速稳健的儿科 MRI

• 批准号: 9595406
• 负责人: Michael Lustig
• 金额: $ 70.33万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9595406
• 关键词: Acoustics; Address; Adult; Algorithms; Anesthesia procedures; Body Image; Body part; Bolus Infusion; Breathing; Child; Child Health; Childhood; Clinic; Clinical; Clinical Research; Computational Technique; Contrast Media; Coupled; Data; Data Quality; Development; Diagnostic Imaging; Diffusion Magnetic Resonance Imaging; Disease; Ensure; Exposure to; Frequencies; Funding; Goals; Healthcare; Image; Image Compression; Image Enhancement; Injections; Ionizing radiation; Legal patent; Letters; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Methods; Modality; Morphologic artifacts; Motion; Motivation; Noise; Patients; Pediatric Oncology; Pediatrics; Population; Protocols documentation; Radiation; Resolution; Risk; Role; Running; Scanning; Speed; System; T2 weighted imaging; Techniques; Technology; Testing; Three-Dimensional Imaging; Time; Transplantation; Validation; Work; base; cancer risk; clinical practice; clinical translation; community setting; compliance behavior; contrast enhanced; design and construction; experience; high dimensionality; image reconstruction; imaging system; innovation; multidisciplinary; novel; pediatric patients; programs; radiation risk; reconstruction; skills; soft tissue; volunteer

Project Abstract Motivation: This is a competing renewal of our successful project, Rapid Robust Pediatric MRI, R01 EB009690. MRI offers superb soft tissue contrast for children, without the ionizing radiation and cancer risk of CT. However, MRI use has been limited due to long exams, low spatial resolution, and motion-artifacts. Thus, MRI often requires prolonged anesthesia with breath-holds and attendant risk; hence, children often lack the benefits of cross-sectional imaging altogether or are exposed to ionizing radiation. The previous project addressed these concerns by creating a dedicated pediatric imaging system. Highly par- allel, high-SNR 3T receive coil arrays were designed and constructed specifically for pediatric body imaging. The high SNR was used to accelerate scans reconstructed with a combination of parallel imaging, new mo- tion correction algorithms, compressed sensing (CS), and higher dimensional imaging. The resulting system is now being used extensively in clinical practice, significantly reducing anesthesia depth and duration, and has markedly increased our MRI utilization. Key technologies have been or are now being commercialized with GE Healthcare, including the pediatric receive array, CS, 4D flow, full-Fourier single-shot T2-weighted scanning, and coil compression. Siemens has licensed five of our patents, implemented them in work-in-progress packages, and productized our coil compression and our ESPIRiT coil sensitivity estimation. Philips has licensed three of our patents. This ensures broad impact. Approach: Despite significant progress and reduced anesthesia depth and duration, patient cooperation re- mains the main limitation to eliminate anesthesia in all pediatric body MRI exams. Many children will cooperate for several minutes, but then fidget and get out of the scanner. Others are content until acoustic noise agi- tates them. Therefore the major emphasis now is greater exam execution speed, comprehensive elimination of acoustic noise, and increased robustness, particularly to contrast agent injection. The project has three interrelated development aims, validated by clinical studies. Aim 1 will enable fast 2D imag- ing for quiet T2 and quiet low-distortion diffusion weighted imaging. A second aim is to develop free-breathing 3D contrast-enhanced and diffusion-weighted imaging that is silent and motion-robust. The third aim will enable au- tomated, smart scanning to speed the exam execution and adaptive protocols to increase the exam robustness. The impact of all of these developments in the clinic will then be assessed to assess the resulting reduction of anesthesia. Significance: This work will lead to fast, robust, broadly-applicable pediatric MRI protocols with less anes- thesia, making MRI safer, cheaper, and more available to children. MRI will be transformed into a workhorse modality, reducing CT radiation burden. The techniques will facilitate wide application in the community setting and permit new MRI applications, for both pediatric and adult diseases.

项目摘要 动机：这是我们成功项目Rapid Robust Pediatric MRI R 01的竞争性更新 EB009690。MRI为儿童提供了极好的软组织对比度，没有电离辐射和癌症风险 的CT。然而，由于检查时间长、空间分辨率低和运动伪影，MRI的使用受到限制。因此，在本发明中， MRI通常需要长时间的麻醉，伴有屏气和伴随的风险;因此，儿童通常缺乏 因此，患者可能无法完全受益于横断面成像，或暴露于电离辐射。 先前的项目通过创建专用的儿科成像系统来解决这些问题。高度标准化- 高SNR 3 T接收线圈阵列专门为儿科身体成像而设计和构建。 高SNR用于加速扫描重建，并行成像，新的运动， 校正算法、压缩传感（CS）和更高维成像。由此产生的系统是 目前已广泛用于临床实践，显著降低了麻醉深度和持续时间， 显著提高了我们的核磁共振成像利用率 关键技术已经或正在与GE Healthcare进行商业化，包括儿科接收 阵列、CS、4D回波、全傅立叶单次激发T2加权扫描和线圈压缩。西门子已授权 我们的五项专利，将其实施在正在进行的工作包中，并将我们的线圈压缩和 我们的ESPIRiT线圈灵敏度估计。飞利浦已经授权了我们的三项专利。这确保了广泛的影响。 方法：尽管取得了显著进展，麻醉深度和持续时间减少，但患者的合作仍然存在。 主要限制是在所有儿科身体MRI检查中消除麻醉。很多孩子会配合 几分钟，然后找到并离开扫描仪。其他人则很满意，直到声学噪音agi- tates他们。因此，现在的主要重点是更大的考试执行速度，全面消除 声学噪声和增加的鲁棒性，特别是对于造影剂注射。 该项目有三个相互关联的发展目标，并通过临床研究进行了验证。目标1将实现快速2D图像- 安静T2和安静低失真弥散加权成像。第二个目标是开发自由呼吸的3D 对比度增强和弥散加权成像是无声的和运动鲁棒的。第三个目标将使Au- 自动化智能扫描可加快检查执行速度，自适应协议可提高检查稳健性。 然后将评估诊所所有这些发展的影响，以评估由此减少的 麻醉 意义：这项工作将导致快速，强大，广泛适用的儿科MRI协议， 让MRI更安全，更便宜，更适合儿童。核磁共振成像将被改造成 减少CT辐射负担。这些技术将有助于在社区环境中广泛应用 并允许新的MRI应用于儿科和成人疾病。