Skeletal muscle: development, regeneration and disease

骨骼肌：发育、再生和疾病

• 批准号: 9762683
• 负责人: Alessandra Sacco
• 金额: $ 2.5万
• 依托单位: SOCIETY FOR MUSCLE BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762683
• 关键词: Address; Area; Attention; Basic Science; Biology; Biomedical Engineering; Cell Aging; Clinical; Collaborations; Communities; Congenital diaphragmatic hernia; Country; Derivation procedure; Development; Disease; Disease model; Drug Screening; Duchenne muscular dystrophy; Elderly; Ensure; Epigenetic Process; Exclusion; Extracellular Matrix; Facioscapulohumeral; Faculty; Fertilization; Fostering; Generations; Genetic; Genetic Diseases; Genetic Transcription; Geography; Goals; Heterotopic Ossification; Human; In Vitro; International; Italy; Maintenance; Malignant Neoplasms; Mentors; Minority; Modeling; Molecular and Cellular Biology; Muscle; Muscle Development; Muscle satellite cell; Muscular Dystrophies; Myoblasts; Myopathy; Natural regeneration; Nuclear; Pathogenesis; Policies; Positioning Attribute; Postdoctoral Fellow; Regulation; Replacement Therapy; Research; Research Personnel; Rhabdomyosarcoma; Role; Science; Scientist; Series; Skeletal Muscle; Slide; Societies; Stem Cell Development; Students; Telomere Shortening; Time; Tissues; Translational Research; Woman; Work; career; career development; career networking; cell type; design; doctoral student; experience; frontier; graduate student; human disease; improved; in vitro Model; induced pluripotent stem cell; meetings; muscle regeneration; myogenesis; novel; novel strategies; posters; professor; programs; repaired; symposium; therapeutic development; therapy development; tissue repair; tool; unpublished works

Sacco, Alessandra Summary The goal of the Skeletal muscle: development, regeneration and disease conference is to bring together international leaders in skeletal muscle research to provide a forum for cutting edge genetic, cellular and molecular biology underlying muscle development, regeneration and disease. This Frontiers in Myogenesis series organized by the Society for Muscle Biology has been held every three years for the last twenty years and has successfully defined the state of the art in the field. The 2019 meeting will not only discuss recent discoveries in skeletal muscle development and repair, but will also encompass advances in our understanding of human diseases, including muscular dystrophies and cancer. Our keynote speaker will be Dr. Pura Muñoz-Cánoves, who has performed exceptional work in muscle stem cell aging and rejuvenating strategies. Ten plenary sessions are planned, presenting 59 speakers (31 invited speakers and 28 selected from submitted abstracts) at the senior, mid-career and junior levels. Topics addressed will include: skeletal muscle development, myoblast fusion and nuclear positioning, regulation of muscle stem cell (MuSC) quiescence, activation, epigenetic control of MuSC, novel approaches for the derivation of MuSC from induced pluripotent stem cells, bioengineering platforms for skeletal muscle modeling, role of the tissue microenvironment in skeletal muscle repair and disease, muscular dystrophies, and cancer. Invited speakers have been selected for their scientific excellence, with particular attention to appropriate representation (39% women/minorities) and geographical diversity (45% are from non-US countries). Speakers are explicitly required to present unpublished work, to ensure scientific discussions focused at the forefront of the field. Importantly, and for the first time, we have liaised with the organizers of the Gordon Research Conference on Myogenesis (Italy, June 2019), to avoid all overlap in invited speakers at the two meetings. This mutual-exclusion policy has dramatically increased the range of young scientists (26% at Assistant Professor level) invited to speak, giving them the invaluable opportunity to present at an international conference. We have also designed the program to accommodate 28 short talks selected from abstracts, to again offer more opportunities for junior faculty and postdoc/students to present. Finally, we will have three poster sessions each accompanied by a “posters blitz” where selected poster presenters will give a one-minute talk to highlight their work, to provide invaluable experience in presenting and facilitate networking. To further foster interaction, we will organize lunch sessions where speakers are distributed and attendees can sign up to join their tables. This meeting will provide a forum for discussing recent discoveries in skeletal muscle research, and foster cross-fertilization from diverse areas of research, to further advance our understanding of muscle biology and help in development of therapeutics.

亚历山德拉？塞萨尔 总结 Skeleton muscle的目标：发展，再生和疾病会议是带来 聚集在骨骼肌研究的国际领导人，为尖端遗传学， 肌肉发育、再生和疾病的细胞和分子生物学基础。这些边界 在肌肉生物学协会组织的肌肉发生系列已举行每三年一次， 在过去的二十年里，它成功地定义了该领域的最新技术水平。2019年会议将 不仅讨论骨骼肌发育和修复的最新发现， 我们对人类疾病，包括肌营养不良症和癌症的理解的进步。我们 主旨发言人将是Pura Muñoz-Cánoves博士，他在肌干方面做了出色的工作 细胞衰老和恢复活力的策略。计划举行10次全体会议，共有59位发言人（31 邀请演讲人和从提交的摘要中选出的28人）。 讨论的主题将包括：骨骼肌发育，成肌细胞融合和核定位， 肌肉干细胞（MuSC）静止、激活的调节，MuSC的表观遗传控制，新的 从诱导多能干细胞衍生MuSC的方法， 骨骼肌建模，组织微环境在骨骼肌修复和疾病中的作用， 肌肉萎缩症和癌症。特邀演讲者因其科学成就而被选中， 特别注意适当的代表性（妇女/少数群体占39%）和地域多样性 (45%来自非美国国家）。演讲者被明确要求展示未发表的作品， 确保科学讨论集中在该领域的最前沿。重要的是，我们第一次 已与戈登肌生成研究会议（意大利，2019年6月）的组织者联系， 以避免两次会议的特邀发言者出现重叠。这种相互排斥的政策 增加了年轻科学家的范围（26%为助理教授级别），邀请他们发言， 出席国际会议的宝贵机会。我们还设计了 举办28个从摘要中挑选出来的简短讲座，再次为年轻人提供更多机会， 教师和博士后/学生介绍。最后，我们将有三个海报会议， 举行“海报闪电战”，由海报制作人以一分钟的演讲，介绍他们的作品， 在介绍和促进网络方面提供宝贵的经验。为了进一步促进互动，我们将 组织午餐会，演讲者被分配，与会者可以注册加入他们的桌子。 这次会议将提供一个论坛，讨论骨骼肌研究的最新发现， 促进来自不同研究领域的交叉施肥，以进一步推进我们对肌肉的理解 生物学和帮助开发治疗方法。