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Animal Resources

动物资源

基本信息

批准号：
10686124
负责人：
Alessandra Sacco
金额：
$ 18.5万
依托单位：
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686124
关键词：
Acceleration Accreditation Animal Model Animals Behavioral Blood Blood Cells Body Weight Breeding Cancer Center Cancer Center Support Grant Caring Censuses Collaborations Communication Computer software Contract Services Core Facility Data Analyses Development Doctor of Philosophy Employee Equipment Experimental Designs Faculty Fatty acid glycerol esters Feedback Fluorescence Genetic study Grant Growth Growth and Development function House mice Housing IACUC Imaging technology Individual Injections Institution Intramuscular Intravenous Investigation Lead Leadership Magnetic Resonance Imaging Maintenance Malignant Neoplasms Measurement Metabolic Modeling Mus Neoplasm Metastasis Operative Surgical Procedures Oral Paper Perfusion Positron-Emission Tomography Postoperative Period Procedures Protocols documentation Publications Rattus Research Research Personnel Resource Sharing Resources Roentgen Rays Sampling Sanitation Science Scientist Serum Services Sterilization Stress Surveys System Tail Techniques Technology Testing Time Tissue Banks Training Training Technics Veins Weaning Work Xenograft Model animal care animal facility animal resource cost effective cost effectiveness efficacy study genetic pedigree imaging modality in vivo in vivo imaging intraperitoneal irradiation luminescence mammary meetings member patient derived xenograft model programs repaired single photon emission computed tomography square foot subcutaneous tumor tumor growth tumor progression ultrasound ventilation

项目摘要

ABSTRACT – ANIMAL RESOURCES SHARED RESOURCE The Animal Resources Shared Resource is a Cancer Center-managed Shared Resource that provides a comprehensive animal care and use program for Center investigators. The facility has been AAALAC-accredited since 1988. The Core provides five basic types of services: (1) husbandry and equipment sanitation/sterilization, (2) mouse breeding procedures and maintenance; (3) procedural techniques training and support; (4) in vivo imaging, blood analysis, and irradiation; and (5) veterinary services and administrative/IACUC support. The animal facility currently occupies 25,602 sq. ft of space in four buildings. Mice are the primary species used, with occasional housing of rats. Over the last 5-year grant period, AR averaged 8,389 occupied mouse cages per month, with growth in the last 2 years to more than 9,000 cages/month. The mice are housed in individually ventilated caging systems. There is sufficient capacity for growth, as the facility is capable of maintaining up to 13,000 cages but generally operates at ~70% capacity, which facilitates breeding colony maintenance and protocol housing requirements. AR provides full-service animal care that includes all husbandry as well as setting up breedings, weaning litters, obtaining tail samples, maintaining animal pedigrees, census and IDs. This comprehensive service is also cost-effective, with the per diem including those services at $0.72/cage for standard mice. The AR staff perform an additional range of services for Center investigators, including intravenous (tail and retro-orbital veins), subcutaneous, intradermal, intramuscular, intraperitoneal, and mammary fat pad injections, oral gavage, tumor measurements, blood and tissue collection, body weights, perfusions, and pre- and post-operative surgical care. The Core provides essential scientific support to Center members by supplying animal models and expert technical assistance for investigation of tumor development and growth in vivo. The Tumor Analysis facility is a key resource in this respect, providing access to a variety of xenograft models, including patient-derived xenografts, and further assisting with the experimental design and carrying out studies of genetic factors or experimental compounds that influence tumor growth and metastasis. This service is supported by an array of sophisticated imaging modalities for evaluating tumor progression, including luminescence, fluorescence, and ultrasound. Additional Animal Analysis services include blood cell, serum, behavioral, and metabolic analysis. In the past five years, 44 Investigators from all three Cancer Center programs have made extensive use of the Animal Resources, and the Core has provided support for the publication of 116 cancer-relevant papers by Cancer Center investigators.

摘要-动物资源共享资源