San Diego Nathan Shock Center

项目摘要-研究开发核心 SD-NSC研究发展核心(ResDev Core)将为以下人员的职业发展提供支持 进入基础衰老生物学领域的初级研究人员，以及希望加入的知名研究人员 老龄化研究领域。具体地说，ResDev核心将支持SD-NSC的科学目标 通过促进职业发展提高对细胞异质性在衰老过程中作用的认识 以三种不同的方式发展老龄研究人员：1)为感兴趣的项目提供种子资金 在利用SD-NSC研究资源核心提供的独特科学服务方面 (老龄化核心的人类细胞模型、老龄化核心的异质性和老龄化核心的综合模型)，2)由 在三个研究资源所涵盖的科学服务方面提供概念和实践培训 核心，以及3)通过在初级和高级成员之间建立个性化的指导计划 NSC网络和其他网络。ResDev Core将由Sanford Burnham Prebys的Malene Hansen博士领导 医学发现研究所(SBP)，提供当地、国家和国际的老龄化研究知识，以及 在指导初级科学家方面具有广泛的专业知识和高度的积极性。该方法将利用一种高度 综合创新的方法，在沿线的科学核心提供概念和实践培训 在赠款撰写和职业发展方面提供正式的指导。首先，一项双轨试点赠款计划将是 启动申请者申请核心使用和指导的资金，可以直接从提交的 申请或通过赠款编写支持计划。第二，举办为期一天的工作坊，提供有关 科学核心将在一年一度的La Jolla Aging会议的第二天举行，免费进行一天的老化 由索尔克研究人员在圣地亚哥索尔克生物研究所(索尔克)组织的研讨会 和SBP。本研讨会将重点介绍由三位科学家提供的技术和分析模块 核心，以及有关科学核心服务的潜在职业轨迹的信息。此外，上的一个模块 将提供助学金写作。第三，也是最后一点，将在#年建立双轨个性化指导方案 哪些初级研究人员将由成熟的调查人员指导，作为试点拨款计划的一部分 或者通过在全国NSC会议和其他会议上形成的导师-导师关系配对。

PROJECT SUMMARY – Research Development Core The SD-NSC Research Development Core (ResDev Core) will provide support for career development of junior researchers entering the field of basic aging biology, as well as established investigators who wish to join the field of aging research. Specifically, the ResDev Core will support the scientific goals of SD-NSC to enhance the understanding of the role of cell heterogeneity in the aging process by promoting career development of aging researchers in three different ways: 1) by providing seed funding for projects interested in taking advantage of the unique scientific services offered by the SD-NSC Research Resource Cores (Human Cell Models of Aging Core, Heterogeneity of Aging Core, and Integrative Models of Aging Core), 2) by providing conceptual and practical training in the scientific services covered by the three Research Resource Cores, and 3) by establishing a personalized mentoring program between junior and senior members of the NSC network and beyond. The ResDev Core will be led by Dr. Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute (SBP), who brings local, national, and international aging research knowledge, and extensive expertise and high motivation in mentoring junior scientists. The approach will capitalize on a highly integrative and innovative approach by providing conceptual and practical training in the scientific Cores along with formalized mentoring in grant writing and career development. First, a two-track pilot grant program will be launched in which applicants apply for funding for Core usage and mentoring, either directly from submitted applications or via a grant-writing support program. Second, a one-day workshop to provide training in the scientific Cores will take place the day after the yearly La Jolla Aging Meeting, a free one-day aging symposium at the Salk Institute for Biological Studies (Salk) in San Diego organized by researchers at Salk and SBP. This workshop will feature modules on the techniques and analyses provided by the three scientific cores, along with information about potential career tracks in scientific Core services. In addition, a module on grant writing will be offered. Third and finally, a two-track personalized mentoring program will be established in which junior researchers will be mentored by established investigators, either as part of the pilot grant program or via pairing of mentee-mentor relationships formed at national NSC meetings, and beyond.