Frontiers in Stem Cells in Cancer(FriSC2)

癌症干细胞前沿（FriSC2）

• 批准号: 9765168
• 负责人: GERALD SCHATTEN
• 金额: $ 31.33万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9765168
• 关键词: Advanced Malignant Neoplasm; Advisory Committees; African American; American; Attention; Biomedical Research; Cancer Education Grant Program; Cancer Survivor; Child; Clinical Research; Collaborations; Color; Development Plans; Doctor of Philosophy; Education; Educational workshop; Ensure; Ethics; Faculty; Fertility; Fostering; Funding; Health Sciences; Hispanic Americans; Individual; Institution; Instruction; Investigation; Investments; Laboratories; Laboratory Research; Malignant Neoplasms; Methods; Minority-Serving Institution; Mission; Molecular Genetics; Morehouse School of Medicine; Nature; Outcome; Participant; Physicians; Quality of life; Recurrence; Research; Research Design; Research Personnel; Scientist; Series; Stem Cell Research; Stem cells; Students; Time; Training; Underrepresented Minority; Universities; Woman; anticancer research; base; cancer cell; cancer education; cancer stem cell; cancer therapy; career; career development; clinically relevant; cost effective; design; education research; ethical legal social implication; frontier; genetic approach; innovation; lectures; medical schools; mid-career faculty; minority scientist; minority trainee; next generation; peer; professor; programs; public health relevance; skill acquisition; skills; tool; training opportunity; underrepresented minority student

 DESCRIPTION (provided by applicant): We seek renewal of R25 "Cancer Research Education Program" sponsorship to sustain and enhance advanced short-term, intensive laboratory and didactic annual courses entitled Frontiers in Stem Cells in Cancer (FriSC2). Designed for competitive scientists and physician-scientists, FriSC2 provides innovative, sophisticated cancer education exclusively at institutions serving primarily under-represented minority (URM) students. Importantly, the cancer stem cell field continues to grow swiftly, and there are too few laboratories led by URM scientists and too few new URM trainees. To ensure that the next generation of cancer researchers has advanced training opportunities, we seek 5 years of sponsorship to offer FriSC2 courses at Morehouse School of Medicine in 2016, 2018, and 2020 and Ponce Health Sciences University in 2017 and 2019. FriSC2 is under the overall directorship of Gerald Schatten from Pittsburgh, along with Idhaliz Flores from Ponce, Winston Thompson from Morehouse, and Calvin Simerly, also from Pitt and is overseen by an external scientific advisory committee. FriSC2 offers dynamic advanced training courses consisting of daily lectures on emerging concepts, followed by extended discussion, laboratory research, technologically intense workshops and informal seminars over week-long periods. This advanced instruction provides "hands-on" training for 16 highly competitive participants (the ratio of applicant inquiries to accepted candidates is >4.4: 1). Of the 64 participants formally trained, 33% identify as African American and 30% as Hispanic American; 61% are women, and 61% are from URM institutions. While the first trainees are only 4 years out of the course, early results show that they are progressing in cancer research careers, investigating a variety of relevant and important topics. Four specific aims are proposed: 1. Provide conceptual education and experimental training in the methods necessary for investigations of cancer and stem cells. 2. Provide participants with specific opportunities to implement career planning tools in collaboration with our senior and junior faculty-including individual development plans and peer-to-peer and personalized coaching-to foster career development and to explore career alternatives. 3. Educate participants on the ethical, legal and social implications of pluripotent and cancer stem cell research and the regulatory landscape in which such research occurs so that students begin their own research programs in the most ethical and responsible manner and avoid needless pitfalls and delays. 4. Provide unbiased, quantitative, independent mechanisms to track trainees' careers, comprehensively and longitudinally, to ensure that the program constitutes a wise, cost-effective investment. The purpose of renewing these training courses, then, is to provide a series of daily discussions and hands-on laboratory research taught by renowned cancer research leaders, resulting in comprehensive, sophisticated training in research strategies and state-of-the-art methods in cellular, molecular and genetic approaches for advancing the Frontiers in Stem Cells in Cancer. In so doing, we will continue to enhance and expand the research careers of the most promising scientists, with sensitivity to ensuring full diversity in the NCI workforce.

 描述（由申请人提供）：我们寻求R25“癌症研究教育计划”赞助的更新，以维持和加强高级短期，强化实验室和教学年度课程，题为癌症干细胞前沿（FriSC 2）。专为有竞争力的科学家和医生科学家，FRSC 2提供创新，先进的癌症教育专门在机构服务主要是代表性不足的少数民族（URM）的学生。重要的是，癌症干细胞领域继续快速增长，由URM科学家领导的实验室太少，新的URM学员太少。为了确保下一代癌症研究人员有先进的培训机会，我们寻求5年的赞助，在2016年，2018年和2020年在莫尔豪斯医学院和2017年和2019年在庞塞健康科学大学提供FriSC 2课程。FriSC 2由匹兹堡的Gerald Schatten、Ponce的Idhaliz弗洛雷斯、Morehouse的Winston Thompson和同样来自Pitt的卡尔文Simerly共同领导，并由外部科学咨询委员会监督。FriSC 2提供动态的高级培训课程，包括每日关于新兴概念的讲座，然后是为期一周的长期讨论，实验室研究，技术密集型研讨会和非正式研讨会。这一高级指导为16名竞争激烈的参与者提供了“实践”培训（申请人查询与接受的候选人的比例>4.4：1）。在接受正式培训的64名参与者中，33%为非洲裔美国人，30%为西班牙裔美国人; 61%为妇女，61%来自URM机构。虽然第一批学员只有4年的课程，早期的结果表明，他们正在癌症研究事业的进步，调查各种相关和重要的主题。提出了四个具体目标：1。提供癌症和干细胞调查所需方法的概念教育和实验培训。2.为参与者提供具体的机会，与我们的高级和初级教师合作实施职业规划工具，包括个人发展计划和点对点和个性化的辅导，以促进职业发展和探索职业选择。3.教育参与者多能和癌症干细胞研究的伦理，法律的和社会影响，以及此类研究发生的监管环境，以便学生开始自己的研究计划，以最道德和负责任的方式，避免不必要的陷阱和延误。4.提供公正、定量、独立的机制，全面、纵向地跟踪学员的职业生涯，以确保该计划是明智、具有成本效益的投资。更新这些培训课程的目的是提供一系列由著名癌症研究领导者教授的日常讨论和动手实验室研究，从而在细胞，分子和遗传方法的研究策略和最先进的方法方面进行全面，复杂的培训，以推进癌症干细胞的前沿。在这样做的过程中，我们将继续加强和扩大最有前途的科学家的研究事业，以确保NCI劳动力的充分多样性。