2/2-GEOHealth Hub-Improving Agricultural Health in Southeast Asia-US

2/2-GEOHealth Hub-改善东南亚-美国农业健康

• 批准号: 9762999
• 负责人: Pornpimol Kongtip
• 金额: $ 28.99万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762999
• 关键词: Acute; Adrenal Glands; Adrenal hormone preparation; Agricultural Workers; Agriculture; Area; Biological Markers; Chronic Disease; Coronary heart disease; Cross-Sectional Studies; Data; Data Collection; Development; Diabetes Mellitus; Disease; Economics; Educational workshop; Endocrine; Endocrine Disruptors; Environmental Health; Event; Exposure to; Extramural Activities; Faculty; Funding; Future; Genetic Polymorphism; Grant; Health; Health Policy; Healthcare Systems; Herbicides; Homeostasis; Hormones; Hypothalamic structure; Informal Sectors; Insecticides; Institution; Interdisciplinary Study; International; Link; Manuscripts; Massachusetts; Medical Staff; Mentors; Mentorship; Metabolic Diseases; Metabolic syndrome; Metabolism; Occupational Health; Occupations; Pesticides; Pilot Projects; Pituitary Gland; Policies; Population; Public Health; Publications; Research; Research Project Grants; Research Training; Risk; Security; Southeastern Asia; Stroke; Thailand; Thyroid Gland; Training; Training Programs; Universities; Work; climate change; design; farmer; hypothalamic-pituitary-adrenal axis; hypothalamic-pituitary-thyroid axis; improved; institutional capacity; member; neurobehavioral; novel strategies; occupational health/safety; programs; recruit; southeast Asian; tool; web site

 DESCRIPTION (provided by applicant): In our planning grant we found that agricultural workers in Thailand (42% of the working population) were self- employed (informal sector), with little economic security, no formal occupational health & safety protections and significant exposures to pesticides. Thus they represent a population in need of research to policy initiatives. The initial research of our GEOHealth HUB (Mahidol University, Thailand & University of Massachusetts, USA) will focus on the agricultural health research question of whether some pesticides, widely used in Southeast Asian agriculture, act as endocrine disrupters, altering endocrine hormone homeostasis and resulting in increased risk of metabolic syndrome and associated diseases such as diabetes, stroke and coronary heart disease, all of which are on the rise in Thailand. In the paired research application (1/2-GEOHealth HUB: Improving Agricultural Health in Southeast Asia-Thailand), we hypothesize that disruption of the hypothalamic-pituitary-thyroid (HPT) axis and hypothalamic-pituitary-adrenal (HPA) axis hormone homeostasis is a biomarker of risk for the development of metabolic disorders, and that several widely used pesticides act as HPT/HPA disrupters. To evaluate our hypothesis we will: 1) Use the Thai Universal Health Care System data to conduct a cross-sectional study of metabolic disorders by occupation; 2) Evaluate sub-chronic changes in HPT & HPA hormones longitudinally among Thai organic and pesticide using farmers; 3) Examine the acute endocrine impacts of pesticide spraying events for selected insecticides & herbicides; 4) Evaluate the impact of genetic polymorphisms on pesticide metabolism. This proposed research project represents the initial focus of our GEOHealth Hub, but future projects will extend the range of agricultural health research and expand into other related occupational & environmental health topics (climate change, other chronic diseases, neurobehavioral health and other work sectors). The matched training program for the GEOHealth Hub focuses on institutional capacity building through a program of mentored research training for 15 junior faculty and medical staff over 5 years at our partner institutions (initially Mahidol University and the Thai Ministry of Public Health). Each trainee will have a Mentorship Team (Thai and U.S. mentors). The training program will include: a) 1 month Introduction to GEOHealth program at Mahidol; b) 6 months of research specific training and mentorship in the U.S. (UMass, Rutgers or Mt. Sinai), resulting in a funded interdisciplinary project that extends the research being conducted in the paired research application; c) data collection, analysis and manuscript(s) from the approved research project, supported by Mentorship Team. The program is designed to establish an international, interdisciplinary collaborative research group that will continue to work together in the future. The training program will link with our proposed research project through extensions of the current project aims and pilot projects that extend the scope of the research in agricultural health, aiding the GEOHealth Hub to expand its research capacity. As the Hub develops, we will add new training partners from other Thai and Southeast Asian universities and institutions. We will use short term training to recruit future institutional partners through existing public healt networks (ThaiPHEIN, SEAPHEIN & APACPH) and to create opportunities for Hub members to interact and develop ideas for new approaches to agricultural health research. Research findings and tools, as well as training materials will be disseminated via our website and through our short term training workshops and seminars. We expect increased research capacity will be reflected in publications (number and quality), extramural funding, multidisciplinary collaborations, development of new research areas and agricultural health policy changes.

 描述（由申请人提供）：在我们的规划拨款中，我们发现泰国的农业工人（占劳动人口的 42%）是个体经营者（非正规部门），缺乏经济保障，没有正式的职业健康和安全保护，并且大量接触农药。因此，他们代表了需要研究政策举措的人群。我们的GEOHealth HUB（泰国玛希隆大学和美国马萨诸塞大学）的初步研究将重点关注农业健康研究问题，即东南亚农业中广泛使用的某些农药是否会充当内分泌干扰物，改变内分泌激素稳态并导致代谢综合征和糖尿病、中风和冠心病等相关疾病的风险增加， 所有这些都在泰国呈上升趋势。在配对研究应用（1/2-GEOHealth HUB：改善东南亚-泰国的农业健康）中，我们假设下丘脑-垂体-甲状腺（HPT）轴和下丘脑-垂体-肾上腺（HPA）轴激素稳态的破坏是代谢性疾病发生风险的生物标志物，并且多种广泛应用 使用过的农药可作为 HPT/HPA 干扰剂。为了评估我们的假设，我们将：1）使用泰国全民医疗保健系统数据对按职业划分的代谢性疾病进行横断面研究； 2) 纵向评估泰国有机和农药使用农民中 HPT 和 HPA 激素的亚慢性变化； 3) 检查农药喷洒事件对选定杀虫剂和除草剂的急性内分泌影响； 4) 评价基因多态性对农药代谢的影响。该拟议的研究项目代表了我们 GEOHealth 中心的最初重点，但未来的项目将扩大农业健康研究的范围，并扩展到其他相关的职业和环境健康主题（气候变化、其他慢性疾病、神经行为健康和其他工作部门）。 GEOHealth 中心的配套培训计划侧重于机构能力建设，通过在我们的合作机构（最初是玛希隆大学和泰国公共卫生部）为 15 名初级教职人员和医务人员提供为期 5 年的指导性研究培训计划。每个学员都会有一个导师团队（泰国和美国导师）。培训计划将包括： a) 玛希隆为期 1 个月的 GEOHealth 简介计划； b) 在美国（麻省大学、罗格斯大学或西奈山大学）进行 6 个月的研究特定培训和指导，从而形成一个受资助的跨学科项目，扩展配对研究应用中正在进行的研究； c) 在导师团队的支持下，从已批准的研究项目中收集数据、分析和手稿。该项目旨在建立一个国际化、跨学科的合作研究小组，未来将继续合作。该培训计划将通过扩展当前项目目标和扩大农业健康研究范围的试点项目，与我们拟议的研究项目联系起来，帮助 GEOHealth 中心扩大其研究能力。随着中心的发展，我们将增加来自其他泰国和东南亚大学和机构的新培训合作伙伴。我们将利用短期培训，通过现有的公共卫生网络（ThaiPHEIN、SEAPHEIN 和 APACPH）招募未来的机构合作伙伴，并为中心成员创造机会进行互动并开发农业健康研究新方法的想法。研究结果和工具以及培训材料将通过我们的网站以及短期培训讲习班和研讨会进行传播。我们预计研究能力的提高将体现在出版物（数量和质量）、校外资助、多学科合作、新研究领域的开发和农业卫生政策的变化上。

项目成果

Determinants of Hypertension amongst Rice Farmers in West Java, Indonesia.

• DOI: 10.3390/ijerph19031152
• 发表时间: 2022-01-20
• 期刊: International journal of environmental research and public health
• 作者: Prihartono NA;Fitria L;Ramdhan DH;Fitriyani F;Fauzia S;Woskie S
• 通讯作者: Woskie S

Comparison of Thyroid Hormone Levels between Women Farmers and Non-Farmers in Banten Indonesia.

• DOI: 10.3390/ijerph18126618
• 发表时间: 2021-06-19
• 期刊: International journal of environmental research and public health
• 作者: Mardhiyah D;Komaruddin WN;Jalal FN;Wuryanti S;Bahri S;Qomariah Q;Sosiawan I;Marsiati H;Legiono L;Hanif H;Woskie S;Kongtip P
• 通讯作者: Kongtip P

Risk factors associated with hand tractor related injuries among rice farmers in Thailand.

泰国稻农手拖拉机相关伤害的危险因素。

• DOI: 10.1080/10807039.2021.2014301
• 发表时间: 2022
• 期刊: Human and ecological risk assessment : HERA
• 作者: Tangtong,Chaiyanun;Yoosook,Wittaya;Kongtip,Pornpimol;Woskie,Susan
• 通讯作者: Woskie,Susan

Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers.

• DOI: 10.3390/ijerph17218140
• 发表时间: 2020-11-04
• 期刊: International journal of environmental research and public health
• 作者: Seesen M;Lucchini RG;Siriruttanapruk S;Sapbamrer R;Hongsibsong S;Woskie S;Kongtip P
• 通讯作者: Kongtip P

Hydrogeogenic fluoride in groundwater and dental fluorosis in Thai agrarian communities: a prevalence survey and case-control study.

• DOI: 10.1186/s12903-021-01902-8
• 发表时间: 2021-10-22
• 期刊: BMC oral health
• 影响因子: 2.9
• 作者: Rojanaworarit C;Claudio L;Howteerakul N;Siramahamongkol A;Ngernthong P;Kongtip P;Woskie S
• 通讯作者: Woskie S