Diabetes: Glucose Control and Beyond

糖尿病：血糖控制及其他

• 批准号: 9913727
• 负责人: Thale Cross Jarvis
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913727
• 关键词: Adipose tissue; Bioenergetics; Biology; Cells; Climate; Collaborations; Diabetes Mellitus; Discipline; Disease; Educational process of instructing; Educational workshop; Endocrinology; Epidemic; Epidemiology; Exposure to; Functional disorder; Genes; Genetic; Glucose Intolerance; Goals; Habits; Industry; Insulin Resistance; International; Islet Cell; Knowledge; Life Style; Link; Liver; Metabolic; Metabolism; Methodology; Mitochondria; Modernization; Molecular; Myocardium; New Mexico; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Occupations; Organ; Outcome; Overnutrition; Pancreas; Participant; Peripheral; Physiology; Prevalence; Research; Research Personnel; Signal Transduction; Skeletal Muscle; Societies; Students; Technology; blood glucose regulation; cardiometabolism; career; clinical practice; combat; comorbidity; detection of nutrient; diabetes mellitus genetics; energy balance; experience; glycemic control; insight; interest; islet; meetings; posters; programs; symposium; translational scientist

ABSTRACT Support is requested for a Keystone Symposia conference entitled Diabetes: Glucose Control and Beyond, organized by Drs. Alan D. Attie and Deborah M. Muoio. The conference will be held in Santa Fe, New Mexico from January 27-31, 2020. Modern technology has created a favorable climate for the “perfect metabolic storm”. Triggered by lifestyle habits that promote overnutrition and inactivity, Westernized societies are experiencing epidemic rates of obesity and its attendant co-morbidities. Foremost among these is type 2 diabetes mellitus, which is projected to reach a global prevalence of 10% by the year 2045. This grim epidemiological forecast has inspired intense efforts to unravel the molecular mechanisms that link positive energy balance to glucose intolerance and metabolic decline. This conference will assemble international leaders and rising stars in diverse biomedical disciplines with common interests in understanding and combatting cardiometabolic diseases. The program showcases new insights into the molecular underpinnings of obesity-induced dysfunction of the major peripheral organs that coordinate energy flux and glucose control: skeletal and cardiac muscles, the pancreas, adipose tissue, the liver and gut. Thematic emphasis will center on nutrient sensing and signaling, inter-organ crosstalk, mechanisms of insulin resistance, mitochondrial bioenergetics, islet biology and genetics of diabetes. A major goal of the conference is to provide a forum that encourages interactions between basic and translational scientists at all career levels to critically evaluate recent advances and current controversies. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting on Islet Biology: From Gene to Cell to Micro-Organ, which will consider metabolism in relation to islet function, in addition to studies of islet cell plasticity and differentiation.

摘要 请求为题为糖尿病：血糖控制和超越的Keystone研讨会提供支持， 由艾伦·D·阿蒂博士和黛博拉·M·穆约博士组织。会议将在新墨西哥州的圣达菲举行 2020年1月27日至31日。 现代科技为《完美新陈代谢风暴》营造了良好的氛围。由生活方式引发 提倡营养过剩和缺乏运动的习惯，西方化社会正在经历 肥胖症及其伴发疾病。其中最重要的是2型糖尿病，预计 到2045年达到10%的全球流行率。这一严峻的流行病学预测激起了强烈的 努力揭开正能量平衡与糖耐量异常和 新陈代谢衰退。本次会议将汇聚各种生物医学领域的国际领袖和后起之秀。 在理解和抗击心脏代谢性疾病方面有共同兴趣的学科。该计划 展示了对肥胖引起的主要脑功能障碍的分子基础的新见解 协调能量流动和血糖控制的外周器官：骨骼肌和心肌，胰腺， 脂肪组织、肝脏和肠道。主题重点将集中在营养传感和信号传递，器官间 串扰、胰岛素抵抗机制、线粒体生物能量学、胰岛生物学和糖尿病遗传学。 会议的一个主要目标是提供一个论坛，鼓励基础和 所有职业水平的翻译科学家对最近的进展和当前的争议进行批判性的评估。 在小岛上同时举行的会议将进一步加强跨学科互动的机会 生物学：从基因到细胞再到微器官，它将考虑代谢与胰岛功能的关系，在 除了研究胰岛细胞的可塑性和分化。