CSHL 2020 PARP Family & ADP-Ribosylation Conference

冷泉港实验室会议 PARP家族与ADP核糖基化 2020年4月1日至4日 项目摘要 这项提议寻求支持将在以下地点举行的“PARP家族和ADP-核糖化”会议 冷泉港实验室(CSHL)于2020年4月1日至4日举行。ADP-核糖基化是一种翻译后 单、多(ADP-核糖基)转移酶家族(PARP)对蛋白质的修饰 家庭)。PARP蛋白具有催化ADP-核糖转移的内在酶活性 (ADPR)单位从烟酰胺腺嘌呤二核苷酸(NAD+)到靶蛋白，从而调节它们的 活动。最近的研究强调了ADP-核糖化反应在多种疾病中的重要作用 细胞在生理和病理状态下的功能。对于PAPS和ADP来说，这是一个激动人心的时刻- 核糖化，三种FDA批准的PARP抑制剂正用于临床治疗癌症和 其他有前景的应用正在探索中。这次会议将召集该领域的领导人，以及 初级教师、博士后研究员和研究生，介绍、回顾和讨论当前关于 PAPS和ADP-核糖化，特别是当它们与癌症、炎症和代谢紊乱有关时。 PAPS和ADP-核糖化在广泛的生理过程中发挥着不同的作用(例如，DNA 修复、维持基因组完整性、新陈代谢、激素信号、基因调控和RNA生物学) 以及病理生理过程(癌症、炎症、应激、代谢性疾病和衰老)。这个独一无二的 及时的会议将把致力于不同系统和使用不同方法的科学家聚集在一起。 这次会议的目的是介绍、回顾和讨论当前的研究，涵盖(1)历史领域 对PARP领域的重要性，例如核PARP在DNA修复中的作用，以及 基因调控和RNA生物学中的核部分；(2)非核部分和单(ADP-核糖基) 转移酶；(3)与PARP功能相互作用或控制NAD+代谢的蛋白质；(4)广泛的 PARP发挥作用的生物系统和疾病状态的光谱，(5)PARP的治疗作用 治疗癌症等疾病的抑制剂，以及(6)解决关键问题所需的方法学进展 该领域的剩余问题。此外，本次会议将为以下人员提供职业发展机会 受训人员和讨论当前问题和规划PARP领域未来的论坛。 每期会议将由该领域的一位顶尖科学家主持。口头报告将由 尊敬的特邀演讲者，以及从摘要中挑选的演讲者。这些人将包括毕业生 学生、博士后研究员和初级教职员工，旨在最大限度地纳入年轻研究人员和 通常在生物医学科学中代表性较低的群体。特别重要的是海报环节， 许多与会者可以在有利于非正式讨论的气氛中介绍他们的工作。我们 预计将有大约175人参加，绝大多数人会展示海报或演讲。总体而言，这次会议-- PARP领域的总理会议-将支持强有力的思想交流和促进合作。

Cold Spring Harbor Laboratory Conference on The PARP Family and ADP-ribosylation April 1 - 4, 2020 Project Summary This proposal seeks support for a meeting on “The PARP Family and ADP-ribosylation” to be held at Cold Spring Harbor Laboratory (CSHL) on April 1 - 4, 2020. ADP-ribosylation is a posttranslational modification of proteins catalyzed by a family of mono- and poly(ADP-ribosyl) transferase enzymes (the PARP family). PARP proteins possess an intrinsic enzymatic activity that catalyzes the transfer of ADP-ribose (ADPR) units from nicotinamide adenine dinucleotide (NAD+) onto target proteins, thereby modulating their activities. Recent studies have highlighted the diverse and important roles of ADP-ribosylation reactions in cellular functions in physiological and pathological states. This is an exciting time for PARPs and ADP- ribosylation, with three FDA-approved PARP inhibitors being used in the clinic for the treatment of cancer and other promising applications being explored. This meeting will assemble leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to present, review, and discuss current research on PARPs and ADP-ribosylation, especially as they pertain to cancer, inflammation, and metabolic disorders. PARPs and ADP-ribosylation play diverse roles in a broad range of physiological processes (e.g., DNA repair, maintenance of genome integrity, metabolism, hormone signaling, gene regulation, and RNA biology) and pathophysiological processes (cancer, inflammation, stress, metabolic diseases, and aging). This unique and timely meeting will bring together scientists working on different systems and using different approaches. The aims of this meeting are to present, review, and discuss current research covering (1) areas of historical importance to the PARP field, such as the role of nuclear PARPs in DNA repair, as well as emerging roles for nuclear PARPs in gene regulation and RNA biology; (2) non-nuclear PARPs and the mono(ADP-ribosyl) transferases; (3) proteins that functionally interact with PARPs or control NAD+ metabolism; (4) a broad spectrum of biological systems and disease states in which PARPs function, (5) the therapeutic utility of PARP inhibitors in treating diseases, such as cancers, and (6) methodological advances required to address critical remaining questions in the field. In addition, this meeting will provide career development opportunities for trainees and a forum for discussing current issues and planning the future of the PARP field. Each session will be chaired by a leading scientist in the field. Oral presentations will be given by distinguished invited speakers, as well as speakers selected from the abstracts. These will include graduate students, postdoctoral fellows, and junior faculty, aiming for maximal inclusion of young investigators and groups typically underrepresented in the biomedical sciences. Of special importance is the poster session, where many participants can present their work in an atmosphere conducive to informal discussions. We expect about 175 people to attend, with the vast majority presenting a poster or talk. Overall, this meeting - the premier meeting in the PARP field - will support the robust exchange of ideas and promote collaborations.