Charting a New Course for Heart Failure: From Discovery to Data

摘要 请求支持Keystone研讨会会议，题为绘制心力衰竭的新路线： 从发现到数据，由Mansoor Husain博士、Benoit G.Bruneau博士和Marc Pfeffer博士组织。这个 会议将于2020年3月1日至5日在科罗拉多州的Keystone举行。 心力衰竭是一个全球性的健康问题，它的患病率、发病率和难治性死亡率都在不断增加。 而有影响力的治疗进展相对较少。这一独特的多学科会议 将汇聚一流的临床医生和科学家，分享关于遗传、环境、 心力衰竭的医源性和病理生理学机制。该计划包括特定的课程和 研讨会的重点是心脏纤维化、免疫学、新陈代谢、再生医学、 生物医学工程，以及对与这种疾病相关的大数据集的分析方法。尽管 计划是多样的，每一次会议都将解决心力衰竭生物学中的一个科学前沿问题，潜在的治疗方法 并将被框定以解决一个尚未回答的重要临床问题。这种创新的格式是 有目的地计划强调心力衰竭的翻译机会，并提供一个论坛， 鼓励心血管研究人员和实习生之间以不同的观点进行对话，但 有一个共同的目标，那就是对心力衰竭产生影响。本次大会将与《新洞察力》配对 进入运动的生物学。“这两个Keystone研讨会将举行联席会议，审查 运动生理学及其如何影响心脏能量和肥大，这将是感兴趣的 出席这两个会议的观众。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Charting a New Course for Heart Failure: From Discovery to Data, organized by Drs. Mansoor Husain, Benoit G. Bruneau and Marc Pfeffer. The conference will be held in Keystone, Colorado from March 1-5, 2020. Heart failure is global health problem of increasing prevalence, high morbidity, and refractory mortality, for which there have been relatively few impactful therapeutic advances. This unique multidisciplinary conference will bring together leading clinicians and scientists to share the latest insights on genetic, environmental, iatrogenic and pathophysiological mechanisms of heart failure. The program includes specific sessions and workshops focused on advances in cardiac fibrosis, immunology, metabolism, regenerative medicine, biomedical engineering, and analytical approaches to large datasets of relevance to this disease. Although the program is diverse, each session will address a scientific frontier in heart failure biology of potential therapeutic relevance and will be framed to address an unanswered, important clinical question. This innovative format is purposefully planned to highlight translational opportunities in heart failure and to provide a forum that encourages dialogue between cardiovascular researchers and trainees with distinct perspectives, but who share a common goal of making an impact in heart failure. This conference will be paired with “New Insights into the Biology of Exercise.” These two Keystone Symposia conferences will share a joint session examining exercise physiology and how it affects cardiac energetics and hypertrophy, which will be of interest to audiences attending either conference.