Columbia Integrated Training Program in Infectious Diseases Research

项目摘要 这是哥伦比亚大学医学中心（CISC）的博士后培训更新申请 在传染病赠款题为“哥伦比亚传染病研究综合培训计划（TP- IDR）"。Scott Hammer博士和富兰克林Lowy博士将继续担任多个PI下的主要研究者（PI） NIH模型。两人都是成熟的研究人员，具有互补的研究兴趣， 培训新的调查人员。该提案的目标是培养博士后研究员， MD或MD-PhD学位，他们注定要从事学术传染病职业。跨学科计划 旨在提供必要的技能，以成功地进行翻译研究，无论这项研究 主要是基础或临床/流行病学。微生物基因组学领域的巨大进步， 生物医学信息学以及这些快速发展的工具在转化研究中的潜在应用， 需要重新评估我们培训新调查员的方法。目前正在征聘 世界级的调查人员（例如，Megan Sykes博士，转化免疫学中心;大卫戈尔茨坦博士， 基因组医学研究所）结合传染病、病原体发现方面的现有优势 (Dr. Ian Lipkin，感染和免疫中心），生物医学信息学（乔治Hripcsak博士）和逆转录病毒- 宿主蛋白质相互作用（Stephen Goff博士，霍华德休斯医学研究所）使我们能够构建一个 培训计划，可以识别和培养人才。新成立的TP-IDR 当前的资助周期不仅产生了新的研究人员，而且还激发了人们对传染病的新兴趣 疾病研究更广泛地在cnc。正在寻求重新提交，以继续取得成功 到目前为止，并确保其未来。Hammer博士和Lowy博士将继续担任执行指导委员会的共同主席。 作为管理机构的委员会。招聘和招聘小组委员会将确保我们的 申请人群体强大而多样。一个由资深调查员和初级调查员组成的动态组合， 聚集在一起形成一个紧密团结的，专注的教师队伍。被选中参加TP-IDR的学员可以选择实验室- 基于或临床/流行病学为基础的研究项目，并有获得硕士学位的选择 流行病学或生物医学信息学。教学会议和综合TP-IDR研讨会 补充教育经验。指导、培训、职业发展和反馈是彻底的。 一个咨询委员会，包括机构内外的成员，将协助监督 节目机构支助是强有力的，基础广泛。微生物基因组学、生物医学 信息学和发病机理与临床调查、转化研究、流行病学和全球健康 形成了TP-IDR的概念愿景。该计划允许我们培训学术传染病 未来的领导者。

Project Abstract This is a renewal application from the Columbia University Medical Center (CUMC) for a post-doctoral training grant in Infectious Diseases entitled “Columbia Integrated Training Program in Infectious Disease Research (TP- IDR)”. Drs. Scott Hammer and Franklin Lowy will remain as principal investigators (PIs) under the multiple PI NIH model. Both are established investigators with complementary research interests and longstanding commitments to the training of new investigators. The goal of this proposal is to train post-doctoral fellows with MD or MD-PhD degrees who are destined for academic infectious disease careers. The interdisciplinary program is designed to provide the necessary skillset to successfully pursue translational research whether this research be primarily basic or clinical/epidemiological. The dramatic advances in the fields of microbial genomics and biomedical informatics and the potential application of these rapidly evolving tools to translational research has necessitated a reappraisal of our approach to training new investigators. The ongoing recruitment to CUMC of world class investigators (e.g., Dr. Megan Sykes, Center for Translational Immunology; Dr. David Goldstein, Institute for Genomic Medicine) combined with pre-existent strengths in Infectious Diseases, pathogen discovery (Dr. Ian Lipkin, Center for Infection and Immunity), Biomedical Informatics (Dr. George Hripcsak) and retroviral- host protein interactions (Dr. Stephen Goff, Howard Hughes Medical Institute) has allowed us to construct a Training Program that can recognize and nurture talented individuals. The TP-IDR, newly established in the current funding cycle, is not only producing new investigators but is also stimulating new interest in Infectious Disease research more broadly at CUMC. Resubmission is being sought to continue the success demonstrated thus far and to secure its future. Drs. Hammer and Lowy will continue to co-chair the Executive Steering Committee that serves as the governing body. A Recruitment and Candidacy Subcommittee will insure that our applicant pool is strong and diverse. A dynamic mix of well-established and junior investigators has been assembled to form a close-knit, dedicated faculty. Trainees selected to the TP-IDR have a choice of laboratory- based or clinical/epidemiological-based research projects and have the option of obtaining a Master’s degree in either Epidemiology or Biomedical Informatics. Didactic conferences and integrated TP-IDR seminars complement the educational experience. Mentorship, training, career development and feedback are thorough. An Advisory Committee, including members from within and outside the institution, will assist with oversight of the program. Institutional support is strong and broad-based. The intersection of microbial genomics, biomedical informatics and pathogenesis with clinical investigation, translational research, epidemiology and global health form the conceptual vision of the TP-IDR. This program permits us to train the academic Infectious Disease leaders of the future.