Transplant Surgery Scientist Training Program

项目总结/摘要 移植有望逆转数百万患有终末期肾病的美国人的临床病程， 阶段性器官衰竭，包括许多胃肠（GI）疾病。然而，一些问题限制了 更广泛地获得移植和各种并发症有关的需要终身 免疫抑制影响移植的长期成功。因此， 移植手术科学家培训计划（TSSTP）是为了促进和支持相互依赖的移植 研究，以改善需要移植的患者的结果。我们将利用科学 跨学科生命科学的进步，并将重点放在推进移植上， 直接和间接地改善需要GI器官的患者的健康，符合以下使命： NIDDK。我们将培养下一代博士后科学家（博士）和临床科学家（医学博士）， 外科和胃肠道医学谁将推动移植领域，最好是作为团队科学家。的 TSSTP的具体目标是：1）教育受训者了解现有障碍的性质， 获得，并降低移植并发症，和2）武装他们与国家的深入了解， 艺术工具，方法和科学方法，可以用来克服这些障碍。 在临床移植中存在显著的“串扰”，因此，我们将应用一个培训计划， 跨学科专家移植研究的模块化方法（MATRIX），一种支持 相互依赖的团队科学和学科间研究的概念。该培训模式将 部署在2个独立的培训轨道，包括1）基础和转化科学研究， 西北大学免疫生物学和生物医学工程移植研究合作组织 （NUCTRIBE），2）西北大学移植内的健康科学和成果研究 成果研究协作（NUTORC），并在我们的第二个资助周期实施这些。共3 学员将受益于2年，每个定制的矩阵，将包括多学科合作， 指导。每个项目都必须与移植手术有直接联系，并且每个项目中的锚定学科都必须与移植手术有直接联系。 MATRIX是一名移植临床医生。T32的战术目标是：1）为以下人员提供津贴支持： 培训生; 2）提供多层次，跨学科的指导，汇集移植临床医生，科学家和 非临床科学家与国家的研究方法学家; 3）保护学员免受临床活动， 竞争他们的时间; 4）维持一个行政结构，提高质量和多样性的 候选人库和受训人员; 5）提供培训机会， 基础/转化科学（NUCTRIBE）到临床/健康服务和成果研究（NUTORC） 与临床移植的交叉;以及6）继续进行评估过程，以确定 该计划是否符合其目标和宗旨。

PROJECT SUMMARY/ABSTRACT Transplantation holds the promise of reversing the clinical course of millions of Americans afflicted with end- stage organ failure, including a number of gastro-intestinal (GI) diseases. However, a number of issues limit broader access to transplantation and various complications related to the need for lifetime immunosuppression affect the long-term success of transplantation. Thus, the long-term objective of the Transplant Surgery Scientist Training Program (TSSTP) is to foster and support inter-dependent transplant research in order improve outcomes for patients in need of transplantation. We will leverage scientific advances in the life sciences across academic disciplines, and focus these on advancing transplantation, directly and indirectly improving the health of patients in need of GI organs, consistent with the mission of NIDDK. We will train the next generation of postdoctoral scientists (PhDs) and clinician scientists (MDs) in surgery and GI medicine who will advance the field of transplantation, preferably as team scientists. The specific aims of the TSSTP are 1) to educate trainees about the nature of existing barriers both to higher access to, and lower complications from transplantation, and 2) to arm them with a deep knowledge of state-of- the art tools, methodologies, and scientific approaches that can potentially be used to overcome these barriers. Significant `cross-talk' exists in clinical transplantation, thus, we will apply a training program that utilizes the Modular Approach to Transplant Research by Inter-disciplinary eXperts (MATRIX), a model that espouses the concept of inter-dependent team science and research between disciplines. This training model will be deployed across 2 separate training tracks that include 1) basic and translational scientific research within the Northwestern University Collaborative for Transplant Research in Immunobiology and Biomedical Engineering (NUCTRIBE), and 2) health sciences and outcomes research within the Northwestern University Transplant Outcomes Research Collaborative (NUTORC), and implement these in our second funding cycle. A total of 3 trainees will benefit for 2 years each from a customized MATRIX that will incorporate multidisciplinary co- mentoring. Each project must have a direct link to transplantation surgery, and the anchoring discipline in each MATRIX is a transplant clinician. The tactical objectives of this T32 are to: 1) provide stipend support for trainees; 2) provide multi-level, inter-disciplinary mentorship bringing together transplant clinician-scientists and non-clinician-scientists with state-of-the research methodologists; 3) protect trainees from clinical activities that compete for their time; 4) sustain an administrative structure that enhances both the quality and diversity of the candidate pool and trainees; 5) provide training opportunities that span the spectrum from both basic/translational science (NUCTRIBE) to clinical/health services and outcomes research (NUTORC) at their intersection with clinical transplantation; and 6) continue an ongoing evaluation process for determining whether or not the program is meeting its goals and objectives.